Title :

Genome-wide meta-analysis of cerebral white matter hyperintensities in patients with stroke

Author(s) :

Traylor, Matthew [Auteur]
Zhang, Cathy R. [Auteur]
Adib-Samii, Poneh [Auteur]
Devan, William J. [Auteur]
Parsons, Owen E. [Auteur]
Lanfranconi, Silvia [Auteur]
Gregory, Sarah [Auteur]
Cloonan, Lisa [Auteur]
Falcone, Guido J. [Auteur]
Radmanesh, Farid [Auteur]
Fitzpatrick, Kaitlin [Auteur]
Kanakis, Allison [Auteur]
Barrick, Thomas R. [Auteur]
Moynihan, Barry [Auteur]
Lewis, Cathryn M. [Auteur]
Boncoraglio, Giorgio B. [Auteur]
Lemmens, Robin [Auteur]
Thijs, Vincent N. S. [Auteur]
Sudlow, Cathie L. M. [Auteur]
Wardlaw, Joanna M. [Auteur]
Rothwell, Peter M. [Auteur]
Meschia, James F. [Auteur]
Worrall, Bradford B. [Auteur]
Levi, Christopher R. [Auteur]
Bevan, Steve [Auteur]
Furie, Karen L. [Auteur]
Dichgans, Martin [Auteur]
Rosand, Jonathan [Auteur]
Markus, Hugh S. [Auteur]
Rost, Natalia S. [Auteur]

Journal title :

Neurology

Abbreviated title :

Neurology

Volume number :

86

Pages :

146-53

Publication date :

2016-01-12

ISSN :

1526-632X

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

OBJECTIVE: For 3,670 stroke patients from the United Kingdom, United States, Australia, Belgium, and Italy, we performed a genome-wide meta-analysis of white matter hyperintensity volumes (WMHV) on data imputed to the 1000 ...
Show more >OBJECTIVE: For 3,670 stroke patients from the United Kingdom, United States, Australia, Belgium, and Italy, we performed a genome-wide meta-analysis of white matter hyperintensity volumes (WMHV) on data imputed to the 1000 Genomes reference dataset to provide insights into disease mechanisms. METHODS: We first sought to identify genetic associations with white matter hyperintensities in a stroke population, and then examined whether genetic loci previously linked to WMHV in community populations are also associated in stroke patients. Having established that genetic associations are shared between the 2 populations, we performed a meta-analysis testing which associations with WMHV in stroke-free populations are associated overall when combined with stroke populations. RESULTS: There were no associations at genome-wide significance with WMHV in stroke patients. All previously reported genome-wide significant associations with WMHV in community populations shared direction of effect in stroke patients. In a meta-analysis of the genome-wide significant and suggestive loci (p < 5 × 10(-6)) from community populations (15 single nucleotide polymorphisms in total) and from stroke patients, 6 independent loci were associated with WMHV in both populations. Four of these are novel associations at the genome-wide level (rs72934505 [NBEAL1], p = 2.2 × 10(-8); rs941898 [EVL], p = 4.0 × 10(-8); rs962888 [C1QL1], p = 1.1 × 10(-8); rs9515201 [COL4A2], p = 6.9 × 10(-9)). CONCLUSIONS: Genetic associations with WMHV are shared in otherwise healthy individuals and patients with stroke, indicating common genetic susceptibility in cerebral small vessel disease.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
CNRS
Inserm
Université de Lille

Collections :

• Lille Neurosciences & Cognition (LilNCog) - U 1172

Research team(s) :

Troubles cognitifs dégénératifs et vasculaires

Submission date :

2019-11-27T14:31:41Z