Title :

Plasma a?42 as biomarker of prodromal alzheimer''s disease progression in patients with amnestic mild cognitive impairment: evidence from the pharmacog/e-adni study

Author(s) :

Albani, Diego [Auteur]
Marizzoni, Moira [Auteur]
Ferrari, Clarissa [Auteur]
Fusco, Federica [Auteur]
Boeri, Lucia [Auteur]
Raimondi, Ilaria [Auteur]
Jovicich, Jorge [Auteur]
Babiloni, Claudio [Auteur]
Soricelli, Andrea [Auteur]
Lizio, Roberta [Auteur]
Galluzzi, Samantha [Auteur]
Cavaliere, Libera [Auteur]
Didic, Mira [Auteur]
Schonknecht, Peter [Auteur]
Molinuevo, Jose Luis [Auteur]
Nobili, Flavio Mariano [Auteur]
Parnetti, Lucilla [Auteur]
Payoux, Pierre [Auteur]
Bocchio-Chiavetto, Luisella [Auteur]
Salvatore, Marco [Auteur]
Rossini, Paolo Maria [Auteur]
Tsolaki, Magda [Auteur]
Visser, Pieter Jelle [Auteur]
Richardson, Jill C. [Auteur]
Wiltfang, Jens [Auteur]
Bordet, Regis [Auteur]
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Troubles cognitifs dégénératifs et vasculaires - U1171
Blin, Olivier [Auteur]
Forloni, Gianluigi [Auteur]
Frisoni, Giovanni B. [Auteur]
Consortium, Pharmacog [Auteur]

Journal title :

Journal of Alzheimer's disease . JAD

Abbreviated title :

J. Alzheimers Dis.

Publication date :

2018-08-20

ISSN :

1875-8908

English keyword(s) :

amyloid-beta peptide
clinical trial
clusterin
PharmaCog project
prodromal Alzheimer''s disease
Amnesic mild cognitive impairment
biomarkers

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

It is an open issue whether blood biomarkers serve to diagnose Alzheimer's disease (AD) or monitor its progression over time from prodromal stages. Here, we addressed this question starting from data of the European FP7 ...
Show more >It is an open issue whether blood biomarkers serve to diagnose Alzheimer's disease (AD) or monitor its progression over time from prodromal stages. Here, we addressed this question starting from data of the European FP7 IMI-PharmaCog/E-ADNI longitudinal study in amnesic mild cognitive impairment (aMCI) patients including biological, clinical, neuropsychological (e.g., ADAS-Cog13), neuroimaging, and electroencephalographic measures. PharmaCog/E-ADNI patients were classified as "positive" (i.e., "prodromal AD" n = 76) or "negative" (n = 52) based on a diagnostic cut-off of Aβ42/P-tau in cerebrospinal fluid as well as APOE ε 4 genotype. Blood was sampled at baseline and at two follow-ups (12 and 18 months), when plasma amyloid peptide 42 and 40 (Aβ42, Aβ40) and apolipoprotein J (clusterin, CLU) were assessed. Linear Mixed Models found no significant differences in plasma molecules between the "positive" (i.e., prodromal AD) and "negative" groups at baseline. In contrast, plasma Aβ42 showed a greater reduction over time in the prodromal AD than the "negative" aMCI group (p = 0.048), while CLU and Aβ40 increased, but similarly in the two groups. Furthermore, plasma Aβ42 correlated with the ADAS-Cog13 score both in aMCI patients as a whole and the prodromal AD group alone. Finally, CLU correlated with the ADAS-Cog13 only in the whole aMCI group, and no association with ADAS-Cog13 was found for Aβ40. In conclusion, plasma Aβ42 showed disease progression-related features in aMCI patients with prodromal AD.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
CNRS
Inserm
Université de Lille

Collections :

• Lille Neurosciences & Cognition (LilNCog) - U 1172

Research team(s) :

Troubles cognitifs dégénératifs et vasculaires

Submission date :

2019-11-27T14:31:47Z