Titre :

Percutaneous repair or medical treatment for secondary mitral regurgitation

Auteur(s) :

Obadia, Jean-François [Auteur]
Messika-Zeitoun, David [Auteur]
Leurent, Guillaume [Auteur]
Iung, Bernard [Auteur]
Bonnet, Guillaume [Auteur]
Piriou, Nicolas [Auteur]
Lefevre, Thierry [Auteur]
Piot, Christophe [Auteur]
Rouleau, Frederic [Auteur]
Carrie, Didier [Auteur]
Nejjari, Mohammed [Auteur]
Ohlmann, Patrick [Auteur]
Leclercq, Florence [Auteur]
Saint Etienne, Christophe [Auteur]
Teiger, Emmanuel [Auteur]
Leroux, Lionel [Auteur]
Karam, Nicole [Auteur]
Michel, Nicolas [Auteur]
Gilard, Martine [Auteur]
Donal, Erwan [Auteur]
Trochu, Jean-Noel [Auteur]
Cormier, Bertrand [Auteur]
Armoiry, Xavier [Auteur]
Boutitie, Florent [Auteur]
Maucort-Boulch, Delphine [Auteur]
Barnel, Cecile [Auteur]
Samson, Geraldine [Auteur]
Guerin, Patrice [Auteur]
Vahanian, Alec [Auteur]
Mewton, Nathan [Auteur]

Titre de la revue :

The New England journal of medicine

Nom court de la revue :

N. Engl. J. Med.

Numéro :

379

Pagination :

2297-2306

Date de publication :

2018-12-13

ISSN :

0028-4793

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

In patients who have chronic heart failure with reduced left ventricular ejection fraction, severe secondary mitral-valve regurgitation is associated with a poor prognosis. Whether percutaneous mitral-valve repair improves ...
Lire la suite >In patients who have chronic heart failure with reduced left ventricular ejection fraction, severe secondary mitral-valve regurgitation is associated with a poor prognosis. Whether percutaneous mitral-valve repair improves clinical outcomes in this patient population is unknown. We randomly assigned patients who had severe secondary mitral regurgitation (defined as an effective regurgitant orifice area of >20 mm2 At 12 months, the rate of the primary outcome was 54.6% (83 of 152 patients) in the intervention group and 51.3% (78 of 152 patients) in the control group (odds ratio, 1.16; 95% confidence interval [CI], 0.73 to 1.84; P=0.53). The rate of death from any cause was 24.3% (37 of 152 patients) in the intervention group and 22.4% (34 of 152 patients) in the control group (hazard ratio, 1.11; 95% CI, 0.69 to 1.77). The rate of unplanned hospitalization for heart failure was 48.7% (74 of 152 patients) in the intervention group and 47.4% (72 of 152 patients) in the control group (hazard ratio, 1.13; 95% CI, 0.81 to 1.56). Among patients with severe secondary mitral regurgitation, the rate of death or unplanned hospitalization for heart failure at 1 year did not differ significantly between patients who underwent percutaneous mitral-valve repair in addition to receiving medical therapy and those who received medical therapy alone. (Funded by the French Ministry of Health and Research National Program and Abbott Vascular; MITRA-FR ClinicalTrials.gov number, NCT01920698 .).Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

CHU Lille
CNRS
Inserm
Université de Lille

Collections :

• Lille Neurosciences & Cognition (LilNCog) - U 1172

Équipe(s) de recherche :

Troubles cognitifs dégénératifs et vasculaires

Date de dépôt :

2019-11-27T14:31:49Z