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Percutaneous repair or medical treatment ...
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Document type :
Article dans une revue scientifique: Article original
DOI :
10.1056/NEJMoa1805374
PMID :
30145927
Permalink :
http://hdl.handle.net/20.500.12210/16572
Title :
Percutaneous repair or medical treatment for secondary mitral regurgitation
Author(s) :
Obadia, Jean-François [Auteur]
Messika-Zeitoun, David [Auteur]
Leurent, Guillaume [Auteur]
Iung, Bernard [Auteur]
Bonnet, Guillaume [Auteur]
Piriou, Nicolas [Auteur]
Lefevre, Thierry [Auteur]
Piot, Christophe [Auteur]
Rouleau, Frederic [Auteur]
Carrie, Didier [Auteur]
Nejjari, Mohammed [Auteur]
Ohlmann, Patrick [Auteur]
Leclercq, Florence [Auteur]
Saint Etienne, Christophe [Auteur]
Teiger, Emmanuel [Auteur]
Leroux, Lionel [Auteur]
Karam, Nicole [Auteur]
Michel, Nicolas [Auteur]
Gilard, Martine [Auteur]
Donal, Erwan [Auteur]
Trochu, Jean-Noel [Auteur]
Cormier, Bertrand [Auteur]
Armoiry, Xavier [Auteur]
Boutitie, Florent [Auteur]
Maucort-Boulch, Delphine [Auteur]
Barnel, Cecile [Auteur]
Samson, Geraldine [Auteur]
Guerin, Patrice [Auteur]
Vahanian, Alec [Auteur]
Mewton, Nathan [Auteur]
Journal title :
The New England journal of medicine
Abbreviated title :
N. Engl. J. Med.
Volume number :
379
Pages :
2297-2306
Publication date :
2018-12-13
ISSN :
0028-4793
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
In patients who have chronic heart failure with reduced left ventricular ejection fraction, severe secondary mitral-valve regurgitation is associated with a poor prognosis. Whether percutaneous mitral-valve repair improves ...
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In patients who have chronic heart failure with reduced left ventricular ejection fraction, severe secondary mitral-valve regurgitation is associated with a poor prognosis. Whether percutaneous mitral-valve repair improves clinical outcomes in this patient population is unknown. We randomly assigned patients who had severe secondary mitral regurgitation (defined as an effective regurgitant orifice area of >20 mm2 At 12 months, the rate of the primary outcome was 54.6% (83 of 152 patients) in the intervention group and 51.3% (78 of 152 patients) in the control group (odds ratio, 1.16; 95% confidence interval [CI], 0.73 to 1.84; P=0.53). The rate of death from any cause was 24.3% (37 of 152 patients) in the intervention group and 22.4% (34 of 152 patients) in the control group (hazard ratio, 1.11; 95% CI, 0.69 to 1.77). The rate of unplanned hospitalization for heart failure was 48.7% (74 of 152 patients) in the intervention group and 47.4% (72 of 152 patients) in the control group (hazard ratio, 1.13; 95% CI, 0.81 to 1.56). Among patients with severe secondary mitral regurgitation, the rate of death or unplanned hospitalization for heart failure at 1 year did not differ significantly between patients who underwent percutaneous mitral-valve repair in addition to receiving medical therapy and those who received medical therapy alone. (Funded by the French Ministry of Health and Research National Program and Abbott Vascular; MITRA-FR ClinicalTrials.gov number, NCT01920698 .).Show less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
CHU Lille
CNRS
Inserm
Université de Lille
Collections :
  • Lille Neurosciences & Cognition (LilNCog) - U 1172
Research team(s) :
Troubles cognitifs dégénératifs et vasculaires
Submission date :
2019-11-27T14:31:49Z
Université de Lille

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