Title :

Outcome of intracerebral hemorrhage associated with different oral anticoagulants

Author(s) :

Wilson, Duncan [Auteur]
Seiffge, David J. [Auteur]
Traenka, Christopher [Auteur]
Basir, Ghazala [Auteur]
Purrucker, Jan C. [Auteur]
Rizos, Timolaos [Auteur]
Sobowale, Oluwaseun A. [Auteur]
Sallinen, Hanne [Auteur]
Yeh, Shin-Joe [Auteur]
Wu, Teddy Y. [Auteur]
Ferrigno, Marc [Auteur]
Houben, Rik [Auteur]
Schreuder, Floris H. B. M. [Auteur]
Perry, Luke A. [Auteur]
Tanaka, Jun [Auteur]
Boulanger, Marion [Auteur]
Salman, Rustam Al-Shahi [Auteur]
Jager, Hans R. [Auteur]
Ambler, Gareth [Auteur]
Shakeshaft, Clare [Auteur]
Yakushiji, Yusuke [Auteur]
Choi, Philip M C. [Auteur]
Staals, Julie [Auteur]
Cordonnier, Charlotte [Auteur]
Troubles cognitifs dégénératifs et vasculaires - U1171
Troubles cognitifs dégénératifs et vasculaires - U 1171 [TCDV]
Troubles cognitifs dégénératifs et vasculaires - U 1171 [TCDV]
Jeng, Jiann-Shing [Auteur]
Veltkamp, Roland [Auteur]
Dowlatshahi, Dar [Auteur]
Engelter, Stefan T. [Auteur]
Parry-Jones, Adrian R. [Auteur]
Meretoja, Atte [Auteur]
Werring, David J. [Auteur]

Journal title :

Neurology

Abbreviated title :

Neurology

Volume number :

88

Pages :

1693-1700

Publication date :

2017-05-02

ISSN :

1526-632X

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

OBJECTIVE: In an international collaborative multicenter pooled analysis, we compared mortality, functional outcome, intracerebral hemorrhage (ICH) volume, and hematoma expansion (HE) between non-vitamin K antagonist oral ...
Show more >OBJECTIVE: In an international collaborative multicenter pooled analysis, we compared mortality, functional outcome, intracerebral hemorrhage (ICH) volume, and hematoma expansion (HE) between non-vitamin K antagonist oral anticoagulation-related ICH (NOAC-ICH) and vitamin K antagonist-associated ICH (VKA-ICH). METHODS: We compared all-cause mortality within 90 days for NOAC-ICH and VKA-ICH using a Cox proportional hazards model adjusted for age; sex; baseline Glasgow Coma Scale score, ICH location, and log volume; intraventricular hemorrhage volume; and intracranial surgery. We addressed heterogeneity using a shared frailty term. Good functional outcome was defined as discharge modified Rankin Scale score ≤2 and investigated in multivariable logistic regression. ICH volume was measured by ABC/2 or a semiautomated planimetric method. HE was defined as an ICH volume increase >33% or >6 mL from baseline within 72 hours. RESULTS: We included 500 patients (97 NOAC-ICH and 403 VKA-ICH). Median baseline ICH volume was 14.4 mL (interquartile range [IQR] 3.6-38.4) for NOAC-ICH vs 10.6 mL (IQR 4.0-27.9) for VKA-ICH (ppppp CONCLUSIONS: In our international collaborative multicenter pooled analysis, baseline ICH volume, hematoma expansion, 90-day mortality, and functional outcome were similar following NOAC-ICH and VKA-ICH.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
CNRS
Inserm
Université de Lille

Collections :

• Lille Neurosciences & Cognition (LilNCog) - U 1172

Research team(s) :

Troubles cognitifs dégénératifs et vasculaires

Submission date :

2019-11-27T14:31:55Z