Title :

Cerebrospinal fluid biomarkers of neurodegeneration, synaptic integrity, and astroglial activation across the clinical alzheimer''s disease spectrum

Author(s) :

Bos, Isabelle [Auteur]
Vos, Stéphanie J. B. [Auteur]
Verhey, Frans R. J. [Auteur]
Scheltens, Philip [Auteur]
Teunissen, Charlotte E. [Auteur]
Engelborghs, Sebastiaan [Auteur]
Sleegers, Kristel [Auteur]
Frisoni, Giovanni B. [Auteur]
Blin, Olivier [Auteur]
Richardson, Jill C. [Auteur]
Bordet, Regis [Auteur]
Troubles cognitifs dégénératifs et vasculaires - U1171
Troubles cognitifs dégénératifs et vasculaires - U 1171 [TCDV]
Troubles cognitifs dégénératifs et vasculaires - U 1171 [TCDV]
Tsolaki, Magda [Auteur]
Popp, Julius [Auteur]
Peyratout, Gwendoline [Auteur]
Martinez-Lage, Pablo [Auteur]
Tainta, Mikel [Auteur]
Lleo, Alberto [Auteur]
Johannsen, Peter [Auteur]
Freund-Levi, Yvonne [Auteur]
Frolich, Lutz [Auteur]
Vandenberghe, Rik [Auteur]
Westwood, Sarah [Auteur]
Dobricic, Valerija [Auteur]
Barkhof, Frederik [Auteur]
Legido-Quigley, Cristina [Auteur]
Bertram, Lars [Auteur]
Lovestone, Simon [Auteur]
Streffer, Johannes [Auteur]
Andreasson, Ulf [Auteur]
Blennow, Kaj [Auteur]
Zetterberg, Henrik [Auteur]
Visser, Pieter Jelle [Auteur]

Journal title :

Alzheimer's & dementia . the journal of the Alzheimer's Association

Abbreviated title :

Alzheimers Dement

Publication date :

2019-03-07

ISSN :

1552-5279

English keyword(s) :

Neurogranin
YKL-40
Cognition
Cerebrospinal fluid
APOE
Alzheimer''s disease
Amyloid-beta
Neurofilament light

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

BACKGROUND: We investigated relations between amyloid-β (Aβ) status, apolipoprotein E (APOE) ε4, and cognition, with cerebrospinal fluid markers of neurogranin (Ng), neurofilament light (NFL), YKL-40, and total tau ...
Show more >BACKGROUND: We investigated relations between amyloid-β (Aβ) status, apolipoprotein E (APOE) ε4, and cognition, with cerebrospinal fluid markers of neurogranin (Ng), neurofilament light (NFL), YKL-40, and total tau (T-tau). METHODS: We included 770 individuals with normal cognition, mild cognitive impairment, and Alzheimer's disease (AD)-type dementia from the EMIF-AD Multimodal Biomarker Discovery study. We tested the association of Ng, NFL, YKL-40, and T-tau with Aβ status (Aβ- vs. Aβ+), clinical diagnosis APOE ε4 carriership, baseline cognition, and change in cognition. RESULTS: Ng and T-tau distinguished between Aβ+ from Aβ- individuals in each clinical group, whereas NFL and YKL-40 were associated with Aβ+ in nondemented individuals only. APOE ε4 carriership did not influence NFL, Ng, and YKL-40 in Aβ+ individuals. NFL was the best predictor of cognitive decline in Aβ+ individuals across the cognitive spectrum. CONCLUSIONS: Axonal degeneration, synaptic dysfunction, astroglial activation, and altered tau metabolism are involved already in preclinical AD. NFL may be a useful prognostic marker.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
CNRS
Inserm
Université de Lille

Collections :

• Lille Neurosciences & Cognition (LilNCog) - U 1172

Research team(s) :

Troubles cognitifs dégénératifs et vasculaires

Submission date :

2019-11-27T14:32:09Z