Titre :

Two-year longitudinal monitoring of amnestic mild cognitive impairment patients with prodromal alzheimer''s disease using topographical biomarkers derived from functional magnetic resonance imaging and electroencephalographic activity

Auteur(s) :

Jovicich, Jorge [Auteur]
Babiloni, Claudio [Auteur]
Ferrari, Clarissa [Auteur]
Marizzoni, Moira [Auteur]
Moretti, Davide V. [Auteur]
Del Percio, Claudio [Auteur]
Lizio, Roberta [Auteur]
Lopez, Susanna [Auteur]
Galluzzi, Samantha [Auteur]
Albani, Diego [Auteur]
Cavaliere, Libera [Auteur]
Minati, Ludovico [Auteur]
Didic, Mira [Auteur]
Fiedler, Ute [Auteur]
Forloni, Gianluigi [Auteur]
Hensch, Tilman [Auteur]
Molinuevo, Jose Luis [Auteur]
Bartres-Faz, David [Auteur]
Nobili, Flavio Mariano [Auteur]
Orlandi, Daniele [Auteur]
Parnetti, Lucilla [Auteur]
Farotti, Lucia [Auteur]
Costa, Cinzia [Auteur]
Payoux, Pierre [Auteur]
Rossini, Paolo Maria [Auteur]
Marra, Camillo [Auteur]
Schonknecht, Peter [Auteur]
Soricelli, Andrea [Auteur]
Noce, Giuseppe [Auteur]
Salvatore, Marco [Auteur]
Tsolaki, Magda [Auteur]
Visser, Pieter Jelle [Auteur]
Richardson, Jill C. [Auteur]
Wiltfang, Jens [Auteur]
Bordet, Regis [Auteur]
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Troubles cognitifs dégénératifs et vasculaires - U1171
Blin, Olivier [Auteur]
Frisoni, Giovanni B. [Auteur]

Titre de la revue :

Journal of Alzheimer's disease . JAD

Nom court de la revue :

J. Alzheimers Dis.

Date de publication :

2018-10-29

ISSN :

1875-8908

Mot(s)-clé(s) en anglais :

prodromal Alzheimer''s disease
resting state
amnesic mild cognitive impairment
electroencephalography
biomarkers
Alpha rhythms
clinical trial
functional magnetic resonance imaging
oddball event-related potentials
PharmaCog project

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Auditory "oddball" event-related potentials (aoERPs), resting state functional magnetic resonance imaging (rsfMRI) connectivity, and electroencephalographic (rsEEG) rhythms were tested as longitudinal functional biomarkers ...
Lire la suite >Auditory "oddball" event-related potentials (aoERPs), resting state functional magnetic resonance imaging (rsfMRI) connectivity, and electroencephalographic (rsEEG) rhythms were tested as longitudinal functional biomarkers of prodromal Alzheimer's disease (AD). Data were collected at baseline and four follow-ups at 6, 12, 18, and 24 months in amnesic mild cognitive impairment (aMCI) patients classified in two groups: "positive" (i.e., "prodromal AD"; n = 81) or "negative" (n = 63) based on a diagnostic marker of AD derived from cerebrospinal samples (Aβ42/P-tau ratio). A linear mixed model design was used to test functional biomarkers for Group, Time, and Group×Time effects adjusted by nuisance covariates (only data until conversion to dementia was used). Functional biomarkers that showed significant Group effects ("positive" versus "negative", p < 0.05) regardless of Time were 1) reduced rsfMRI connectivity in both the default mode network (DMN) and the posterior cingulate cortex (PCC), both also giving significant Time effects (connectivity decay regardless of Group); 2) increased rsEEG source activity at delta (<4 Hz) and theta (4-8 Hz) rhythms and decreased source activity at low-frequency alpha (8-10.5 Hz) rhythms; and 3) reduced parietal and posterior cingulate source activities of aoERPs. Time×Group effects showed differential functional biomarker progression between groups: 1) increased rsfMRI connectivity in the left parietal cortex of the DMN nodes, consistent with compensatory effects and 2) increased limbic source activity at theta rhythms. These findings represent the first longitudinal characterization of functional biomarkers of prodromal AD relative to "negative" aMCI patients based on 5 serial recording sessions over 2 years.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

CHU Lille
CNRS
Inserm
Université de Lille

Collections :

• Lille Neurosciences & Cognition (LilNCog) - U 1172

Équipe(s) de recherche :

Troubles cognitifs dégénératifs et vasculaires

Date de dépôt :

2019-11-27T14:33:09Z