Titre :

Cognitive and imaging markers in non-demented subjects attending a memory clinic: study design and baseline findings of the memento cohort

Auteur(s) :

Dufouil, Carole [Auteur]
Dubois, Bruno [Auteur]
Vellas, Bruno [Auteur]
Pasquier, Florence [Auteur]
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Troubles cognitifs dégénératifs et vasculaires - U1171
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Blanc, Frederic [Auteur]
Hugon, Jacques [Auteur]
Hanon, Olivier [Auteur]
Dartigues, Jean-François [Auteur]
Harston, Sandrine [Auteur]
Gabelle, Audrey [Auteur]
Ceccaldi, Mathieu [Auteur]
Beauchet, Olivier [Auteur]
Krolak-Salmon, Pierre [Auteur]
David, Renaud [Auteur]
Rouaud, Olivier [Auteur]
Godefroy, Olivier [Auteur]
Belin, Catherine [Auteur]
Rouch, Isabelle [Auteur]
Auguste, Nicolas [Auteur]
Wallon, David [Auteur]
Benetos, Athanase [Auteur]
Pariente, Jeremie [Auteur]
Paccalin, Marc [Auteur]
Moreaud, Olivier [Auteur]
Hommet, Caroline [Auteur]
Sellal, François [Auteur]
Boutoleau-Bretonniere, Claire [Auteur]
Jalenques, Isabelle [Auteur]
Gentric, Armelle [Auteur]
Vandel, Pierre [Auteur]
Azouani, Chabha [Auteur]
Fillon, Ludovic [Auteur]
Fischer, Clara [Auteur]
Savarieau, Helen [Auteur]
Operto, Gregory [Auteur]
Bertin, Hugo [Auteur]
Chupin, Marie [Auteur]
Bouteloup, Vincent [Auteur]
Habert, Marie-Odile [Auteur]
Mangin, Jean-François [Auteur]
Chene, Genevieve [Auteur]

Titre de la revue :

Alzheimer's research & therapy

Nom court de la revue :

Alzheimers Res. Ther.

Numéro :

9

Date de publication :

2017-08-29

ISSN :

1758-9193

Mot(s)-clé(s) en anglais :

Cohort studies
Neuroimaging
Natural history studies (prognosis)
Alzheimer''s disease
Cognitive aging

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

BACKGROUND: The natural history and disease mechanisms of Alzheimer's disease and related disorders (ADRD) are still poorly understood. Very few resources are available to scrutinise patients as early as needed and to use ...
Lire la suite >BACKGROUND: The natural history and disease mechanisms of Alzheimer's disease and related disorders (ADRD) are still poorly understood. Very few resources are available to scrutinise patients as early as needed and to use integrative approaches combining standardised, repeated clinical investigations and cutting-edge biomarker measurements. METHODS: In the nationwide French MEMENTO cohort study, participants were recruited in memory clinics and screened for either isolated subjective cognitive complaints (SCCs) or mild cognitive impairment (MCI; defined as test performance 1.5 SD below age, sex and education-level norms) while not demented (Clinical Dementia Rating [CDR] <1). Baseline data collection included neurological and physical examinations as well as extensive neuropsychological testing. To be included in the MEMENTO cohort, participants had to agree to undergo both brain magnetic resonance imaging (MRI) and blood sampling. Cerebral 18 RESULTS: The 2323 participants, recruited from April 2011 to June 2014, were aged 71 years, on average (SD 8.7), and 62% were women. CDR was 0 in 40% of participants, and 30% carried at least one apolipoprotein E ε4 allele. We observed that more than half (52%) of participants had amnestic mild cognitive impairment (17% single-domain aMCI), 32% had non-amnestic mild cognitive impairment (16.9% single-domain naMCI) and 16% had isolated SCCs. Multivariable analyses of neuroimaging markers associations with cognitive categories showed that participants with aMCI had worse levels of imaging biomarkers than the others, whereas participants with naMCI had markers at intermediate levels between SCC and aMCI. The burden of white matter lesions tended to be larger in participants with aMCI. Independently of CDR, all neuroimaging and neuropsychological markers worsened with age, whereas differences were not consistent according to sex. CONCLUSIONS: MEMENTO is a large cohort with extensive clinical, neuropsychological and neuroimaging data and represents a platform for studying the natural history of ADRD in a large group of participants with different subtypes of MCI (amnestic or not amnestic) or isolated SCCs. BACKGROUND: Clinicaltrials.gov, NCT01926249 . Registered on 16 August 2013.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

CHU Lille
CNRS
Inserm
Université de Lille

Collections :

• Lille Neurosciences & Cognition (LilNCog) - U 1172

Équipe(s) de recherche :

Troubles cognitifs dégénératifs et vasculaires

Date de dépôt :

2019-11-27T14:33:27Z
2020-02-19T12:34:19Z