Title :

The use of biomarkers for the etiologic diagnosis of mci in europe: an eadc survey

Author(s) :

Bocchetta, Martina [Auteur]
Galluzzi, Samantha [Auteur]
Kehoe, Patrick Gavin [Auteur]
Aguera, Eduardo [Auteur]
Bernabei, Roberto [Auteur]
Bullock, Roger [Auteur]
Ceccaldi, Mathieu [Auteur]
Dartigues, Jean-François [Auteur]
De Mendonca, Alexandre [Auteur]
Didic, Mira [Auteur]
Eriksdotter, Maria [Auteur]
Felician, Olivier [Auteur]
Froelich, Lutz [Auteur]
Gertz, Hermann-Josef [Auteur]
Hallikainen, Merja [Auteur]
Hasselbalch, Steen G. [Auteur]
Hausner, Lucrezia [Auteur]
Heuser, Isabell [Auteur]
Jessen, Frank [Auteur]
Jones, Roy W. [Auteur]
Kurz, Alexander [Auteur]
Lawlor, Brian [Auteur]
Lleo, Alberto [Auteur]
Martinez-Lage, Pablo [Auteur]
Mecocci, Patrizia [Auteur]
Mehrabian, Shima [Auteur]
Monsch, Andreas [Auteur]
Nobili, Flavio Mariano [Auteur]
Nordberg, Agneta [Auteur]
Olde-Rikkert, Marcel G. M. [Auteur]
Orgogozo, Jean-Marc [Auteur]
Pasquier, Florence [Auteur]
Troubles cognitifs dégénératifs et vasculaires - U1171
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Peters, Oliver [Auteur]
Salmon, Eric [Auteur]
Sanchez-Castellano, Carmen [Auteur]
Santana, Isabel [Auteur]
Sarazin, Marie [Auteur]
Traykov, Latchezar [Auteur]
Tsolaki, Magda [Auteur]
Visser, Pieter Jelle [Auteur]
Wallin, Asa K. [Auteur]
Wilcock, Gordon [Auteur]
Wilkinson, David [Auteur]
Wolf, Henrike [Auteur]
Yener, Goersev [Auteur]
Zekry, Dina [Auteur]
Frisoni, Giovanni B. [Auteur]

Journal title :

Alzheimer's & dementia . the journal of the Alzheimer's Association

Abbreviated title :

Alzheimers. Dement.

Volume number :

11

Pages :

195-206

Publication date :

2015-02-01

ISSN :

1552-5260

English keyword(s) :

Mild cognitive impairment
Diagnosis
Biomarkers
Alzheimer''s disease

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

We investigated the use of Alzheimer's disease (AD) biomarkers in European Alzheimer's Disease Consortium centers and assessed their perceived usefulness for the etiologic diagnosis of mild cognitive impairment (MCI). We ...
Show more >We investigated the use of Alzheimer's disease (AD) biomarkers in European Alzheimer's Disease Consortium centers and assessed their perceived usefulness for the etiologic diagnosis of mild cognitive impairment (MCI). We surveyed availability, frequency of use, and confidence in diagnostic usefulness of markers of brain amyloidosis (amyloid positron emission tomography [PET], cerebrospinal fluid [CSF] Aβ42) and neurodegeneration (medial temporal atrophy [MTA] on MR, fluorodeoxyglucose positron emission tomography [FDG-PET], CSF tau). The most frequently used biomarker is visually rated MTA (75% of the 37 responders reported using it "always/frequently") followed by CSF markers (22%), FDG-PET (16%), and amyloid-PET (3%). Only 45% of responders perceive MTA as contributing to diagnostic confidence, where the contribution was rated as "moderate". Seventy-nine percent of responders felt "very/extremely" comfortable delivering a diagnosis of MCI due to AD when both amyloid and neuronal injury biomarkers were abnormal (P < .02 versus any individual biomarker). Responders largely agreed that a combination of amyloidosis and neuronal injury biomarkers was a strongly indicative AD signature.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
CNRS
Inserm
Université de Lille

Collections :

• Lille Neurosciences & Cognition (LilNCog) - U 1172

Research team(s) :

Troubles cognitifs dégénératifs et vasculaires

Submission date :

2019-11-27T14:34:05Z