Title :

Primary fatty amides in plasma associated with brain amyloid burden, hippocampal volume, and memory in the european medical information framework for alzheimer''s disease biomarker discovery cohort

Author(s) :

Kim, Min [Auteur]
Snowden, Stuart [Auteur]
Suvitaival, Tommi [Auteur]
Ali, Ashfaq [Auteur]
Merkler, David J. [Auteur]
Ahmad, Tahmina [Auteur]
Westwood, Sarah [Auteur]
Baird, Alison L. [Auteur]
Proitsi, Petra [Auteur]
Nevado-Holgado, Alejo J. [Auteur]
Hye, Abdul [Auteur]
Bos, Isabelle [Auteur]
Vos, Stéphanie J. B. [Auteur]
Vandenberghe, Rik [Auteur]
Teunissen, Charlotte E. [Auteur]
Ten Kate, Mara [Auteur]
Scheltens, Philip [Auteur]
Gabel, Silvy [Auteur]
Meersmans, Karen [Auteur]
Blin, Olivier [Auteur]
Richardson, Jill C. [Auteur]
De Roeck, Ellen E. [Auteur]
Sleegers, Kristel [Auteur]
Bordet, Regis [Auteur]
Troubles cognitifs dégénératifs et vasculaires - U1171
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Rami, Lorena [Auteur]
Kettunen, Petronella [Auteur]
Tsolaki, Magda [Auteur]
Verhey, Frans R. J. [Auteur]
Sala, Isabel [Auteur]
Lleo, Alberto [Auteur]
Peyratout, Gwendoline [Auteur]
Tainta, Mikel [Auteur]
Johannsen, Peter [Auteur]
Freund-Levi, Yvonne [Auteur]
Frolich, Lutz [Auteur]
Dobricic, Valerija [Auteur]
Engelborghs, Sebastiaan [Auteur]
Frisoni, Giovanni B. [Auteur]
Molinuevo, Jose Luis [Auteur]
Wallin, Anders [Auteur]
Popp, Julius [Auteur]
Martinez-Lage, Pablo [Auteur]
Bertram, Lars [Auteur]
Barkhof, Frederik [Auteur]
Ashton, Nicholas J. [Auteur]
Blennow, Kaj [Auteur]
Zetterberg, Henrik [Auteur]
Streffer, Johannes [Auteur]
Visser, Pieter Jelle [Auteur]
Lovestone, Simon [Auteur]
Legido-Quigley, Cristina [Auteur]

Journal title :

Alzheimer's & dementia . the journal of the Alzheimer's Association

Abbreviated title :

Alzheimers Dement

Publication date :

2019-04-28

ISSN :

1552-5279

English keyword(s) :

Biomarkers
EMIF-AD
Alzheimer''s disease
Dementia
Amyloid
Tau
CSF
Brain volume measurements
Cognitive function measurements
Metabolomics

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

BACKGROUND: A critical and as-yet unmet need in Alzheimer's disease (AD) is the discovery of peripheral small molecule biomarkers. Given that brain pathology precedes clinical symptom onset, we set out to test whether ...
Show more >BACKGROUND: A critical and as-yet unmet need in Alzheimer's disease (AD) is the discovery of peripheral small molecule biomarkers. Given that brain pathology precedes clinical symptom onset, we set out to test whether metabolites in blood associated with pathology as indexed by cerebrospinal fluid (CSF) AD biomarkers. METHODS: This study analyzed 593 plasma samples selected from the European Medical Information Framework for Alzheimer's Disease Multimodal Biomarker Discovery study, of individuals who were cognitively healthy (n = 242), had mild cognitive impairment (n = 236), or had AD-type dementia (n = 115). Logistic regressions were carried out between plasma metabolites (n = 883) and CSF markers, magnetic resonance imaging, cognition, and clinical diagnosis. RESULTS: Eight metabolites were associated with amyloid β and one with t-tau in CSF, these were primary fatty acid amides (PFAMs), lipokines, and amino acids. From these, PFAMs, glutamate, and aspartate also associated with hippocampal volume and memory. CONCLUSIONS: PFAMs have been found increased and associated with amyloid β burden in CSF and clinical measures.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
CNRS
Inserm
Université de Lille

Collections :

• Lille Neurosciences & Cognition (LilNCog) - U 1172

Research team(s) :

Troubles cognitifs dégénératifs et vasculaires

Submission date :

2019-11-27T14:34:17Z