Title :

Does clot burden score on baseline t2*-mri impact clinical outcome in acute ischemic stroke treated with mechanical thrombectomy?

Author(s) :

Derraz, Imad [Auteur]
Bourcier, Romain [Auteur]
Soudant, Marc [Auteur]
Soize, Sébastien [Auteur]
Ben Hassen, Wagih [Auteur]
Hossu, Gabriella [Auteur]
Clarencon, Frederic [Auteur]
Derelle, Anne Laure [Auteur]
Tisserand, Marie [Auteur]
Raoult, Helene [Auteur]
Legrand, Laurence [Auteur]
Bracard, Serge [Auteur]
Oppenheim, Catherine [Auteur]
Naggara, Olivier [Auteur]
Bonafe, Alain [Auteur]
Leclerc, Xavier [Auteur]
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Troubles cognitifs dégénératifs et vasculaires - U1171
Agrinier, Nelly [Auteur]
Bakchine, Serge [Auteur]
Baronnet, Flore [Auteur]
Beaumont, Marine [Auteur]
Bejot, Yannick [Auteur]
Berge, Jerome [Auteur]
Bintner, Marc [Auteur]
Cho, Tae-Hee [Auteur]
Cogez, Julien [Auteur]
Cordonnier, Charlotte [Auteur]
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Troubles cognitifs dégénératifs et vasculaires - U1171
Denier, Christian [Auteur]
Detante, Olivier [Auteur]
Faivre, Anthony [Auteur]
Ferrier, Anne [Auteur]
Gimenez, Laetitia [Auteur]
Godard, Sophie [Auteur]
Boulouis, Gregoire [Auteur]
Guillon, Benoit [Auteur]
Houdart, Emmanuel [Auteur]
Lapergue, Bertrand [Auteur]
Musacchio, Mariano [Auteur]
Neau, Jean-Philippe [Auteur]
Obadia, Michael [Auteur]
Pasco-Papon, Anne [Auteur]
Piotin, Michel [Auteur]
Pierot, Laurent [Auteur]
Richard, Sébastien [Auteur]
Ricolfi, Frederic [Auteur]
Ronziere, Thomas [Auteur]
Saliou, Guillaume [Auteur]
Sibon, Igor [Auteur]
Sedat, Jacques [Auteur]
Stapf, Christian [Auteur]
Suissa, Laurent [Auteur]
Tisserand, Marie [Auteur]
Turjman, Francis [Auteur]
Velasco, Stéphane [Auteur]

Journal title :

Journal of stroke

Abbreviated title :

J. Stroke

Volume number :

21

Pages :

91-+

Publication date :

2019-01-01

ISSN :

2287-6391

English keyword(s) :

Magnetic resonance imaging
Ischemic stroke
Endovascular recanalization
Thrombosis

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

A long clot, defined by a low (0-6) clot burden score (CBS) assessed by T2*-MR sequence, is associated with worse clinical outcome after intravenous thrombolysis (IVT) for acute ischemic stroke than is a small clot (CBS, ...
Show more >A long clot, defined by a low (0-6) clot burden score (CBS) assessed by T2*-MR sequence, is associated with worse clinical outcome after intravenous thrombolysis (IVT) for acute ischemic stroke than is a small clot (CBS, 7-10). The added benefit of mechanical thrombectomy (MT) might be higher in patients with long clot. The aim of this pre-specified post hoc analysis of the THRombectomie des Artères CErebrales (THRACE) trial was to assess the association between T2*-CBS, successful recanalization and clinical outcome. Of 414 patients randomized in the THRACE trial, 281 patients were included in this analysis. Associations between T2*-CBS and clinical outcome on the modified Rankin Scale (mRS) at 3 months were tested. High T2*-CBS, i.e., small clot, was associated with a shift toward better outcome on the mRS; proportional odds ratio (POR) per point CBS was 1.19 (95% confidence interval [CI], 1.05 to 1.34) in the whole population, 1.34 (95% CI, 1.13 to 1.59) in IVT group, and 1.04 (95% CI, 0.87 to 1.23) in IVTMT group. After adjustment for baseline prognostic variables, the effect of the full scale T2*-CBS was not statistically significant in the whole population and for the IVTMT group but remains significant for the IVT group (POR, 1.32; 95% CI, 1.11 to 1.58). s A small clot, as assessed using T2*-CBS, is associated with improved outcome and may be used as a prognostic marker. Despite the worst outcome with long clot, the relative benefit of MT over IVT seemed to increase with low T2*-CBS and longer clot.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
CNRS
Inserm
Université de Lille

Collections :

• Lille Neurosciences & Cognition (LilNCog) - U 1172

Research team(s) :

Troubles cognitifs dégénératifs et vasculaires

Submission date :

2019-11-27T14:34:23Z