Title :

Outcomes in transcatheter aortic valve replacement for bicuspid versus tricuspid aortic valve stenosis

Author(s) :

Yoon, Sung-Han [Auteur]
Bleiziffer, Sabine [Auteur]
De Backer, Ole [Auteur]
Delgado, Victoria [Auteur]
Arai, Takahide [Auteur]
Ziegelmueller, Johannes [Auteur]
Barbanti, Marco [Auteur]
Sharma, Rahul [Auteur]
Perlman, Gidon Y. [Auteur]
Khalique, Omar K. [Auteur]
Holy, Erik W. [Auteur]
Saraf, Smriti [Auteur]
Deuschl, Florian [Auteur]
Fujita, Buntaro [Auteur]
Ruile, Philipp [Auteur]
Neumann, Franz-Josef [Auteur]
Pache, Gregor [Auteur]
Takahashi, Masao [Auteur]
Kaneko, Hidehiro [Auteur]
Schmidt, Tobias [Auteur]
Ohno, Yohei [Auteur]
Schofer, Niklas [Auteur]
Kong, William K F. [Auteur]
Tay, Edgar [Auteur]
Sugiyama, Daisuke [Auteur]
Kawamori, Hiroyuki [Auteur]
Maeno, Yoshio [Auteur]
Abramowitz, Yigal [Auteur]
Chakravarty, Tarun [Auteur]
Nakamura, Mamoo [Auteur]
Kuwata, Shingo [Auteur]
Yong, Gerald [Auteur]
Kao, Hsien-Li [Auteur]
Lee, Michael [Auteur]
Kim, Hyo-Soo [Auteur]
Modine, Thomas [Auteur]
Troubles cognitifs dégénératifs et vasculaires - U1171
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Wong, S Chiu [Auteur]
Bedogni, Francesco [Auteur]
Testa, Luca [Auteur]
Teiger, Emmanuel [Auteur]
Butter, Christian [Auteur]
Ensminger, Stephan M. [Auteur]
Schaefer, Ulrich [Auteur]
Dvir, Danny [Auteur]
Blanke, Philipp [Auteur]
Leipsic, Jonathon [Auteur]
Nietlispach, Fabian [Auteur]
Abdel-Wahab, Mohamed [Auteur]
Chevalier, Bernard [Auteur]
Tamburino, Corrado [Auteur]
Hildick-Smith, David [Auteur]
Whisenant, Brian K. [Auteur]
Park, Seung-Jung [Auteur]
Colombo, Antonio [Auteur]
Latib, Azeem [Auteur]
Kodali, Susheel K. [Auteur]
Bax, Jeroen J. [Auteur]
Sondergaard, Lars [Auteur]
Webb, John G. [Auteur]
Lefevre, Thierry [Auteur]
Leon, Martin B. [Auteur]
Makkar, Raj R. [Auteur]

Journal title :

Journal of the American College of Cardiology

Abbreviated title :

J. Am. Coll. Cardiol.

Volume number :

69

Pages :

2579-2589

Publication date :

2017-05-30

ISSN :

0735-1097

English keyword(s) :

aortic stenosis
transcatheter aortic valve implantation
bicuspid aortic valve

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

BACKGROUND: Transcatheter aortic valve replacement (TAVR) is being increasingly performed in patients with bicuspid aortic valve stenosis (AS). OBJECTIVE: This study sought to compare the procedural and clinical outcomes ...
Show more >BACKGROUND: Transcatheter aortic valve replacement (TAVR) is being increasingly performed in patients with bicuspid aortic valve stenosis (AS). OBJECTIVE: This study sought to compare the procedural and clinical outcomes in patients with bicuspid versus tricuspid AS from the Bicuspid AS TAVR multicenter registry. METHODS: Outcomes of 561 patients with bicuspid AS and 4,546 patients with tricuspid AS were compared after propensity score matching, assembling 546 pairs of patients with similar baseline characteristics. Procedural and clinical outcomes were recorded according to Valve Academic Research Consortium-2 criteria. RESULTS: Compared with patients with tricuspid AS, patients with bicuspid AS had more frequent conversion to surgery (2.0% vs. 0.2%; p = 0.006) and a significantly lower device success rate (85.3% vs. 91.4%; p = 0.002). Early-generation devices were implanted in 320 patients with bicuspid and 321 patients with tricuspid AS, whereas new-generation devices were implanted in 226 and 225 patients with bicuspid and tricuspid AS, respectively. Within the group receiving early-generation devices, bicuspid AS had more frequent aortic root injury (4.5% vs. 0.0%; p = 0.015) when receiving the balloon-expanding device, and moderate-to-severe paravalvular leak (19.4% vs. 10.5%; p = 0.02) when receiving the self-expanding device. Among patients with new-generation devices, however, procedural results were comparable across different prostheses. The cumulative all-cause mortality rates at 2 years were comparable between bicuspid and tricuspid AS (17.2% vs. 19.4%; p = 0.28). CONCLUSIONS: Compared with tricuspid AS, TAVR in bicuspid AS was associated with a similar prognosis, but lower device success rate. Procedural differences were observed in patients treated with the early-generation devices, whereas no differences were observed with the new-generation devices.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
CNRS
Inserm
Université de Lille

Collections :

• Lille Neurosciences & Cognition (LilNCog) - U 1172

Research team(s) :

Troubles cognitifs dégénératifs et vasculaires

Submission date :

2019-11-27T14:34:41Z