Daptomycin versus vancomycin as post-operative ...
Type de document :
Article dans une revue scientifique: Article original
DOI :
PMID :
URL permanente :
Titre :
Daptomycin versus vancomycin as post-operative empirical antibiotic treatment for prosthetic joint infections: a case-control study
Auteur(s) :
Joseph, C. [Auteur]
CHU Amiens-Picardie
Robineau, Olivier [Auteur]
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Titecat, Marie [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Putman, Sophie [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Blondiaux, Nicolas [Auteur]
Centre Hospitalier Gustave Dron [Tourcoing]
Loiez, Caroline [Auteur]
Institut de Microbiologie [CHRU Lille]
Valette, Michel [Auteur]
Centre Hospitalier Gustave Dron [Tourcoing]
Schmit, J L. [Auteur]
CHU Amiens-Picardie
Beltrand, Eric [Auteur]
Centre Hospitalier Gustave Dron [Tourcoing]
Dezeque, Herve [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Nguyen, Sophie [Auteur]
Migaud, Henri [Auteur]
Marrow Adiposity & Bone Lab - Adiposité Médullaire et Os - ULR 4490 [MABLab]
Senneville, Eric [Auteur]
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
CHU Amiens-Picardie
Robineau, Olivier [Auteur]
![refId](/themes/Mirage2//images/idref.png)
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Titecat, Marie [Auteur]
![refId](/themes/Mirage2//images/idref.png)
Lille Inflammation Research International Center - U 995 [LIRIC]
Putman, Sophie [Auteur]
![refId](/themes/Mirage2//images/idref.png)
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Blondiaux, Nicolas [Auteur]
Centre Hospitalier Gustave Dron [Tourcoing]
Loiez, Caroline [Auteur]
Institut de Microbiologie [CHRU Lille]
Valette, Michel [Auteur]
Centre Hospitalier Gustave Dron [Tourcoing]
Schmit, J L. [Auteur]
CHU Amiens-Picardie
Beltrand, Eric [Auteur]
Centre Hospitalier Gustave Dron [Tourcoing]
Dezeque, Herve [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Nguyen, Sophie [Auteur]
Migaud, Henri [Auteur]
![refId](/themes/Mirage2//images/idref.png)
Marrow Adiposity & Bone Lab - Adiposité Médullaire et Os - ULR 4490 [MABLab]
Senneville, Eric [Auteur]
![refId](/themes/Mirage2//images/idref.png)
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Titre de la revue :
Journal of Bone and Joint Infection
Nom court de la revue :
J Bone Jt Infect
Numéro :
4
Pagination :
72-75
Date de publication :
2019-01-01
ISSN :
2206-3552
Autre identifiant :
PMC6470651
Mot(s)-clé(s) en anglais :
Daptomycin
Vancomycin
empirical antibiotic treatment
prosthetic joint infection
Vancomycin
empirical antibiotic treatment
prosthetic joint infection
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
Purpose: To compare safety and efficacy of Vancomycin (Van) versus Daptomycin (Dap) as post-operative empirical antibiotic treatment (PEAT) in patients with periprosthetic joint infections (PJIs). Methods: Medical charts ...
Lire la suite >Purpose: To compare safety and efficacy of Vancomycin (Van) versus Daptomycin (Dap) as post-operative empirical antibiotic treatment (PEAT) in patients with periprosthetic joint infections (PJIs). Methods: Medical charts of patients treated empirically with Van or Dap in the post-operative period of total hip/knee prosthesis septic revision until the results of intra-operative culture were reviewed. Cefotaxime, cefepime or aztreonam were used in combination with Dap or Van. Results: Twenty Dap patients were matched with 20 other Van patients according to the age and type of prosthesis. The ASA score and the distribution of the pathogens was similar in the two groups especially regarding the number of methicillin-resistant staphylococci. The mean duration of the PEAT was 6.07 ± 0.85 days. A total of 17 episodes of adverse events (AE) in 10 patients (25%) were recorded during the PEAT which led to discontinue the treatment in 5 patients, all of them treated with Van (P=0.02). At the end of a mean post-treatment follow-up of 618 +/- 219 days, 36 patients remained in remission of infection; 2 patients failed in each group. Conclusions: Our observations suggest that PEAT with Van for septic revision of PJIs is associated with a higher discontinuation rate due to AE but with a similar outcome than it is with Dap.Lire moins >
Lire la suite >Purpose: To compare safety and efficacy of Vancomycin (Van) versus Daptomycin (Dap) as post-operative empirical antibiotic treatment (PEAT) in patients with periprosthetic joint infections (PJIs). Methods: Medical charts of patients treated empirically with Van or Dap in the post-operative period of total hip/knee prosthesis septic revision until the results of intra-operative culture were reviewed. Cefotaxime, cefepime or aztreonam were used in combination with Dap or Van. Results: Twenty Dap patients were matched with 20 other Van patients according to the age and type of prosthesis. The ASA score and the distribution of the pathogens was similar in the two groups especially regarding the number of methicillin-resistant staphylococci. The mean duration of the PEAT was 6.07 ± 0.85 days. A total of 17 episodes of adverse events (AE) in 10 patients (25%) were recorded during the PEAT which led to discontinue the treatment in 5 patients, all of them treated with Van (P=0.02). At the end of a mean post-treatment follow-up of 618 +/- 219 days, 36 patients remained in remission of infection; 2 patients failed in each group. Conclusions: Our observations suggest that PEAT with Van for septic revision of PJIs is associated with a higher discontinuation rate due to AE but with a similar outcome than it is with Dap.Lire moins >
Langue :
Anglais
Audience :
Internationale
Vulgarisation :
Non
Établissement(s) :
CHU Lille
Inserm
Univ. Littoral Côte d’Opale
Université de Lille
Inserm
Univ. Littoral Côte d’Opale
Université de Lille
Collections :
Date de dépôt :
2019-12-09T16:48:14Z
2020-05-14T08:43:26Z
2023-12-14T12:43:35Z
2020-05-14T08:43:26Z
2023-12-14T12:43:35Z
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