Title :

Does an intrauterine exchange transfusion improve the fetal prognosis in parvovirus infection cases?

Author(s) :

Vanspranghels, R. [Auteur]
Département d'obstétrique[Lille]
Debarge, Veronique [Auteur]
Environnement Périnatal et Santé - EA 4489
Vaast, Pascal [Auteur]
Département d'obstétrique[Lille]
Coulon, Capucine [Auteur]
Département d'obstétrique[Lille]
Clouqueur, Elodie [Auteur]
Département d'obstétrique[Lille]
Hanssens, Sandy [Auteur]
Environnement périnatal et croissance - EA 4489 [EPS]
Rakza, Thameur [Auteur]
Environnement périnatal et croissance - EA 4489 [EPS]
Subtil, Damien [Auteur]
221576|||Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS] (VALID)
Garabedian, Charles [Auteur]
Département d'obstétrique[Lille]

Journal title :

Transfusion

Abbreviated title :

Transfusion

Volume number :

59

Pages :

185-190

Publisher :

Wiley Online Library

Publication date :

2018-10-04

ISSN :

1537-2995

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Almost 20% of parvovirus B19 foetal infections require intrauterine transfusions. In addition, myocardial dysfunction has been observed in severe parvovirus B19 infections. One objective of an intrauterine exchange transfusion ...
Show more >Almost 20% of parvovirus B19 foetal infections require intrauterine transfusions. In addition, myocardial dysfunction has been observed in severe parvovirus B19 infections. One objective of an intrauterine exchange transfusion (IUET) is to avoid an overload during the transfusion. Our aim was to study the obstetrical and neonatal outcomes in cases of IUETs performed for foetal parvovirus infections and to compare our survival rate to those studies in which simple in utero transfusions were chosen. This was a retrospective monocentre study of all patients followed up for parvovirus B19 infections in which IUETs were performed. An IUET was indicated when foetal hydrops was observed and/or when severe foetal anaemia was diagnosed though an elevation in the middle cerebral artery peak systolic velocity. The characteristics of each pregnancy and the neonatal outcomes were studied until hospital discharge. Thirty-five IUETs were performed in 26 foetuses. The median gestational age of the first IUET was 22.6 weeks. Only one foetal bradycardia incidence was recorded during the procedure. Three medical pregnancy terminations were observed in our series, secondary to severe cerebral anomalies confirmed in the magnetic resonance imaging. Five in utero deaths occurred, in which 2 of the foetuses underwent multiple IUETs. All the neonates had normal haemoglobin levels at birth, and none were transferred to the neonatal intensive care unit. The overall survival rate was 70%. IUETs exhibit a survival rate similar to that of simple intrauterine transfusions in foetal parvovirus infection cases.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
Université de Lille

Collections :

• Environnement Périnatal et Santé - ULR 4489
• METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694

Submission date :

2019-12-09T16:48:43Z
2024-03-27T10:34:27Z