Titre :

A retrospective multicentric study of ewing sarcoma family of tumors in patients older than 50: management and outcome

Auteur(s) :

Rochefort, Pauline [Auteur]
Centre Léon Bérard [Lyon]
Italiano, Antoine [Auteur]

Laurence, Valérie [Auteur]
Institut Curie [Paris]
Penel, Nicolas [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Centre Régional de Lutte contre le Cancer Oscar Lambret [Lille] [UNICANCER/Lille]
Lardy-Cleaud, Audrey [Auteur]
Centre Léon Bérard [Lyon]
Mir, Olivier [Auteur]
Institut Gustave Roussy [IGR]
Chevreau, Christine [Auteur]

Bertucci, François [Auteur]
Institut Paoli-Calmettes [IPC]
Bompas, Emmanuelle [Auteur]
CRLCC René Gauducheau
Chaigneau, Loic [Auteur]

Levy, Dominique [Auteur]
Institut Curie [Paris]
Ryckewaert, Thomas [Auteur]
Centre Régional de Lutte contre le Cancer Oscar Lambret [Lille] [UNICANCER/Lille]
Dumont, Sarah [Auteur]
Institut Gustave Roussy [IGR]
Meeus, Pierre [Auteur]
Centre Léon Bérard [Lyon]
Ranchere-Vince, Dominique [Auteur]
Centre Léon Bérard [Lyon]
Blay, Jean-Yves [Auteur]
Centre Léon Bérard [Lyon]
Cassier, Philippe Alexandre [Auteur]
Centre Léon Bérard [Lyon]

Titre de la revue :

Scientific reports

Nom court de la revue :

Sci Rep

Numéro :

7

Date de publication :

2017-12-20

ISSN :

2045-2322

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Ewing's sarcoma family of tumors (EFTs) is a group of rare and aggressive tumors. Data on EFTs in patients (pts) ≥ 50 years are limited and these pts are often not eligible for clinical trials. Some, but not all, studies ...
Lire la suite >Ewing's sarcoma family of tumors (EFTs) is a group of rare and aggressive tumors. Data on EFTs in patients (pts) ≥ 50 years are limited and these pts are often not eligible for clinical trials. Some, but not all, studies have reported inferior outcome for older pts with EFTs. We conducted an IRB-approved retrospective analysis among centers of the French Sarcoma Group on pts diagnosed with EFTs at age ≥50 between 2000 and 2012. Clinical features, treatment modality and outcomes were analyzed. Seventy-seven pts were identified, including 36 females (46.8%) and the median age at diagnosis was 56 years (range: 50-86). The primary tumor was located in soft tissue in 59 pts (76.6%). Fifty-six pts (72.7%) had localized disease, among them 49 (87.5%) received chemotherapy in addition to local therapy. Their estimated 3-yr OS and event-free survival (EFS) rates were respectively 73.3% and 62.2%. Recurrence occurred in 43 pts. The estimated 3-yr OS rate was 37% in pts with metastatic disease at presentation. EFTs in pts ≥50 years are more likely to originate from soft tissue and their outcomes appear to be worse than that of younger pts treated with modern protocols.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

CHU Lille
Université de Lille

Collections :

• Autres travaux scientifiques

Date de dépôt :

2019-12-09T16:49:09Z
2020-05-20T09:33:56Z