Titre :

Impact of infarct location on functional outcome following endovascular therapy for stroke

Auteur(s) :

Rosso, Charlotte [Auteur]
Institut du Cerveau = Paris Brain Institute [ICM]
Sorbonne Université [SU]
Blanc, Raphael [Auteur]
Fondation Ophtalmologique Adolphe de Rothschild [Paris]
Ly, Julien [Auteur]
Sorbonne Université - Faculté de Médecine [SU FM]
Institut du Cerveau = Paris Brain Institute [ICM]
Samson, Yves [Auteur]
Institut du Cerveau = Paris Brain Institute [ICM]
Sorbonne Université [SU]
Lehericy, Stéphane [Auteur]
Institut du Cerveau = Paris Brain Institute [ICM]
Sorbonne Université [SU]
Gory, Benjamin [Auteur]
Centre Hospitalier Régional Universitaire de Nancy [CHRU Nancy]
Marnat, Gaultier [Auteur]
Centre Hospitalier Universitaire de Bordeaux [CHU Bordeaux]
Mazighi, Mikael [Auteur]
Fondation Ophtalmologique Adolphe de Rothschild [Paris]
Consoli, Arturo [Auteur]
Hôpital Foch [Suresnes]
Labreuche, Julien [Auteur]
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Saleme, Suzana [Auteur]
CHU Limoges
Costalat, Vincent [Auteur]
Hôpital Gui de Chauliac [CHU Montpellier]
Bracard, Serge [Auteur]
Centre Hospitalier Régional Universitaire de Nancy [CHRU Nancy]
Desal, Hubert [Auteur]
Centre Hospitalier Universitaire de Nantes = Nantes University Hospital [CHU Nantes]
Piotin, Michel [Auteur]
Fondation Ophtalmologique Adolphe de Rothschild [Paris]
Lapergue, Bertrand [Auteur]
Hôpital Foch [Suresnes]

Titre de la revue :

Journal of Neurology, Neurosurgery and Psychiatry

Nom court de la revue :

J. Neurol. Neurosurg. Psychiatry

Numéro :

90

Pagination :

313-319

Date de publication :

2018-11-13

ISSN :

1468-330X

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

The relationship between stroke topography (ie, the regions damaged by the infarct) and functional outcome can aid clinicians in their decision-making at the acute and later stages. However, the side (left or right) of the ...
Lire la suite >The relationship between stroke topography (ie, the regions damaged by the infarct) and functional outcome can aid clinicians in their decision-making at the acute and later stages. However, the side (left or right) of the stroke may also influence the identification of clinically relevant regions. We sought to determine which brain regions are associated with good functional outcome at 3 months in patients with left-sided and right-sided stroke treated by endovascular treatment using the diffusion-weighted imaging-Alberta Stroke Program Early CT Score (DWI-ASPECTS). Patients with ischaemic stroke (n = 405) were included from the ASTER trial and Pitié-Salpêtrière registry. Blinded readers rated ASPECTS on day 1 DWI. Stepwise logistic regression analyses were performed to identify the regions related to 3-month outcome in left (n = 190) and right (n = 215) sided strokes with the modified Rankin scale (0-2) as a binary independent variable and with the 10 regions-of-interest of the DWI-ASPECTS as independent variables. Median National Institute of Health Stroke Scale (NIHSS) at baseline was 17 (IQR: 12-20), median age was 70 years (IQR: 58-80) and median day-one NIHSS 9 (IQR: 4-18). Not all brain regions have the same weight in predicting good outcome at 3 months; moreover, these regions depend on the affected hemisphere. In left-sided strokes, the multivariate analysis revealed that preservation of the caudate nucleus, the internal capsule and the cortical M5 region were independent predictors of good outcome. In right-sided strokes, the cortical M3 and M6 regions were found to be clinically relevant. Cortical non-motors areas related to outcome differed between left-sided and right-sided strokes. This difference might reflect the specialisation of the dominant and non-dominant hemispheres for language and attention, respectively. These results may influence decision-making at the acute and later stages. NCT02523261.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

CHU Lille
Université de Lille

Collections :

• METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694

Date de dépôt :

2019-12-09T16:49:58Z
2024-05-23T11:52:51Z