Title :

Does lymphadenectomy improve survival in patients with intermediate risk endometrial cancer? a multicentric study from the francogyn research group

Author(s) :

Bougherara, Lilia [Auteur]
Azais, Henri [Auteur]
Behal, Helene [Auteur]
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Canlorbe, Geoffroy [Auteur]
Ballester, Marcos [Auteur]
Bendifallah, Sofiane [Auteur]
Coutant, Charles [Auteur]
Lavoue, Vincent [Auteur]
Ouldamer, Lobna [Auteur]
Graesslin, Olivier [Auteur]
Touboul, Cyril [Auteur]
Estevez, Juan Pablo [Auteur]
Collinet, Pierre [Auteur]
Thérapies Laser Assistées par l'Image pour l'Oncologie - U 1189 [ONCO-THAI]

Journal title :

International journal of gynecological cancer . official journal of the International Gynecological Cancer Society

Abbreviated title :

Int. J. Gynecol. Cancer

Volume number :

29

Pages :

282-289

Publication date :

2019-02-01

ISSN :

1525-1438

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

The role of lymphadenectomy in intermediate risk endometrial cancer remains uncertain. We evaluated the impact of lymphadenectomy on overall survival and relapse-free survival for patients with intermediate risk endometrial ...
Show more >The role of lymphadenectomy in intermediate risk endometrial cancer remains uncertain. We evaluated the impact of lymphadenectomy on overall survival and relapse-free survival for patients with intermediate risk endometrial cancer. We retrospectively reviewed patients from the FRANCOGYN database with intermediate risk endometrial cancer, based on pre-operative and post-operative criteria (type 1, grade 1-2 tumors with deep (> 50%) myometrial invasion and no lymphovascular space invasion), who received primary surgical treatment between November 2002 and August 2013. We compared overall survival and relapse-free survival between staged and unstaged patients. From 1235 screened patients, we selected 108 patients with intermediate risk endometrial cancer. Eighty-two (75.9%) patients underwent nodal staging (consisting of pelvic +/- para-aortic lymphadenectomy). Among them, 35 (32.4%) had lymph node disease. The median follow-up was 25 months (range 0.4 to 155.0). The overall survival rates were 82.5% for patients staged (CI 64.2 to 91.9) vs 77.9 % for unstaged patients (CI 35.4 to 94.2) (P = 0.73). The relapse-free survival rates were 68.9% for staged patients (CI 51.2 to 81.3) vs 68.8% for unstaged patients (CI 29.1 to 89.3) (P=0.67). Systematic nodal staging does not appear to improve overall survival and relapse-free survival for patients with IR EC but could provide information to tailor adjuvant therapy. Sentinel lymph node dissection may be an effective and less invasive alternative staging technique and should provide a future alternative for this population.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
Inserm
Université de Lille

Collections :

• METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
• Thérapies Lasers Assistées par l'Image pour l'Oncologie (ONCO-THAI) - U1189

Submission date :

2019-12-09T16:50:36Z