Vaginal mucosal homeostatic response may ...
Document type :
Article dans une revue scientifique: Article original
PMID :
Permalink :
Title :
Vaginal mucosal homeostatic response may determine pregnancy outcome in women with bacterial vaginosis a pilot study
Author(s) :
Faure, Emmanuel [Auteur]
Recherche translationelle relations hôte-pathogènes
Faure, Karine [Auteur]
Recherche translationnelle : relations hôte-pathogènes - EA 7366
Recherche translationelle relations hôte-pathogènes
Figeac, Martin [Auteur]
Plateforme de génomique fonctionnelle et structurelle [Lille]
Kipnis, Eric [Auteur]
Recherche translationnelle : relations hôte-pathogènes - EA 7366
Recherche translationelle relations hôte-pathogènes
Grandjean, Teddy [Auteur]
Recherche translationelle relations hôte-pathogènes
Dubucquoi, Sylvain [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Villenet, Celine [Auteur]
Institut pour la Recherche sur le Cancer de Lille [U837 INSERM - IRCL]
Grandbastien, Bruno [Auteur]
Université de Lille
Brabant, Gilles [Auteur]
Hôpital Saint Vincent de Paul de Lille
Subtil, Damien [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Dessein, Rodrigue [Auteur]
Recherche translationnelle : relations hôte-pathogènes - EA 7366
Recherche translationelle relations hôte-pathogènes
Recherche translationelle relations hôte-pathogènes
Faure, Karine [Auteur]

Recherche translationnelle : relations hôte-pathogènes - EA 7366
Recherche translationelle relations hôte-pathogènes
Figeac, Martin [Auteur]

Plateforme de génomique fonctionnelle et structurelle [Lille]
Kipnis, Eric [Auteur]

Recherche translationnelle : relations hôte-pathogènes - EA 7366
Recherche translationelle relations hôte-pathogènes
Grandjean, Teddy [Auteur]

Recherche translationelle relations hôte-pathogènes
Dubucquoi, Sylvain [Auteur]

Lille Inflammation Research International Center - U 995 [LIRIC]
Villenet, Celine [Auteur]
Institut pour la Recherche sur le Cancer de Lille [U837 INSERM - IRCL]
Grandbastien, Bruno [Auteur]
Université de Lille
Brabant, Gilles [Auteur]
Hôpital Saint Vincent de Paul de Lille
Subtil, Damien [Auteur]

METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Dessein, Rodrigue [Auteur]

Recherche translationnelle : relations hôte-pathogènes - EA 7366
Recherche translationelle relations hôte-pathogènes
Journal title :
Medicine
Abbreviated title :
Medicine (Baltimore)
Volume number :
95
Publication date :
2016-02-01
ISSN :
0025-7974
English keyword(s) :
Mesh:Vaginosis
Mesh:Bacterial/immunology*
Mesh:Immunity
Mesh:Mucosal
Mesh:Adult
Mesh:Pilot Projects
Mesh:Homeostasis
Mesh:Humans
Mesh:Female
Mesh:Pregnancy Outcome
Mesh:Pregnancy Complications
Mesh:Infectious/immunology*
Mesh:Pregnancy
Mesh:Bacterial/immunology*
Mesh:Immunity
Mesh:Mucosal
Mesh:Adult
Mesh:Pilot Projects
Mesh:Homeostasis
Mesh:Humans
Mesh:Female
Mesh:Pregnancy Outcome
Mesh:Pregnancy Complications
Mesh:Infectious/immunology*
Mesh:Pregnancy
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
Bacterial vaginosis (BV) is considered as a trigger for an inflammatory response that could promote adverse pregnancy outcome (APO). We hypothesized that BV-related inflammation could be counterbalanced by anti-inflammatory ...
Show more >Bacterial vaginosis (BV) is considered as a trigger for an inflammatory response that could promote adverse pregnancy outcome (APO). We hypothesized that BV-related inflammation could be counterbalanced by anti-inflammatory and mucosal homeostatic responses that could participate in pregnancy outcomes.A total of 402 vaginal self-samples from pregnant women in their first trimester were screened by Nugent score. In this population, we enrolled 23 pregnant women with BV but without APO, 5 pregnant women with BV and developing APO, 21 pregnant women with intermediate flora, and 28 random control samples from pregnant women without BV or APO.BV without APO in pregnant women was associated with 28-fold interleukin-8, 5-fold interleukin-10, and 40-fold interleukin-22 increases in expression compared to controls. BV associated with APO in pregnant women shared 4-fold increase in tumor necrosis factor, 100-fold decrease in interleukin-10, and no variation in interleukin-22 expressions compared to controls. Next-generation sequencing of vaginal microbiota revealed a shift from obligate anaerobic bacteria dominance in BV without APO pregnant women to Lactobacillus dominance microbiota in BV with APO.Our results show that the anti-inflammatory and mucosal homeostatic responses to BV may determine outcome of pregnancy in the setting of BV possibly through effects on the vaginal microbiota.Show less >
Show more >Bacterial vaginosis (BV) is considered as a trigger for an inflammatory response that could promote adverse pregnancy outcome (APO). We hypothesized that BV-related inflammation could be counterbalanced by anti-inflammatory and mucosal homeostatic responses that could participate in pregnancy outcomes.A total of 402 vaginal self-samples from pregnant women in their first trimester were screened by Nugent score. In this population, we enrolled 23 pregnant women with BV but without APO, 5 pregnant women with BV and developing APO, 21 pregnant women with intermediate flora, and 28 random control samples from pregnant women without BV or APO.BV without APO in pregnant women was associated with 28-fold interleukin-8, 5-fold interleukin-10, and 40-fold interleukin-22 increases in expression compared to controls. BV associated with APO in pregnant women shared 4-fold increase in tumor necrosis factor, 100-fold decrease in interleukin-10, and no variation in interleukin-22 expressions compared to controls. Next-generation sequencing of vaginal microbiota revealed a shift from obligate anaerobic bacteria dominance in BV without APO pregnant women to Lactobacillus dominance microbiota in BV with APO.Our results show that the anti-inflammatory and mucosal homeostatic responses to BV may determine outcome of pregnancy in the setting of BV possibly through effects on the vaginal microbiota.Show less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
CHU Lille
Inserm
Université de Lille
Inserm
Université de Lille
Collections :
Submission date :
2019-12-09T16:53:24Z
2020-05-25T07:31:48Z
2021-06-08T12:01:12Z
2020-05-25T07:31:48Z
2021-06-08T12:01:12Z
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