Titre :

Treatment recommendations from the eighth international workshop on waldenstrom's macroglobulinemia

Auteur(s) :

Leblond, Véronique [Auteur]
Kastritis, Efstathios [Auteur]
Advani, Ranjana [Auteur]
Ansell, Stephen M. [Auteur]
Buske, Christian [Auteur]
Castillo, Jorge J. [Auteur]
Garcia-Sanz, Ramon [Auteur]
Gertz, Morie [Auteur]
Kimby, Eva [Auteur]
Kyriakou, Charalampia [Auteur]
Merlini, Giampaolo [Auteur]
Minnema, Monique C. [Auteur]
Morel, Pierre [Auteur]
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Morra, Enrica [Auteur]
Rummel, Mathias [Auteur]
Wechalekar, Ashutosh [Auteur]
Patterson, Christopher J. [Auteur]
Treon, Steven P. [Auteur]
Dimopoulos, Meletios A. [Auteur]

Titre de la revue :

Blood

Nom court de la revue :

Blood

Numéro :

128

Pagination :

1321-1328

Date de publication :

2016-09-08

ISSN :

0006-4971

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Waldenström macroglobulinemia (WM) is a distinct B-cell lymphoproliferative disorder for which clearly defined criteria for the diagnosis, initiation of therapy, and treatment strategy have been proposed as part of the ...
Lire la suite >Waldenström macroglobulinemia (WM) is a distinct B-cell lymphoproliferative disorder for which clearly defined criteria for the diagnosis, initiation of therapy, and treatment strategy have been proposed as part of the consensus panels of the International Workshop on Waldenström's Macroglobulinemia (IWWM). At IWWM-8, a task force for treatment recommendations was impanelled to review recently published and ongoing clinical trial data as well as the impact of new mutations (MYD88 and CXCR4) on treatment decisions, indications for B-cell receptor and proteasome inhibitors, and future clinical trial initiatives for WM patients. The panel concluded that therapeutic strategies in WM should be based on individual patient and disease characteristics. Chemoimmunotherapy combinations with rituximab and cyclophosphamide-dexamethasone, bendamustine, or bortezomib-dexamethasone provide durable responses and are still indicated in most patients. Approval of the BTK inhibitor ibrutinib in the United States and Europe represents a novel and effective treatment option for both treatment-naive and relapsing patients. Other B-cell receptor inhibitors, second-generation proteasome inhibitors (eg, carfilzomib), and mammalian target of rapamycin inhibitors are promising and may increase future treatment options. Active enrollment in clinical trials whenever possible was endorsed by the panel for most patients with WM.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

CHU Lille
Université de Lille

Collections :

• METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694

Date de dépôt :

2019-12-09T16:53:58Z