Title :

Routine drug resistance testing in proviral hiv-1 dna: prevalence of stop codons and hypermutation, and associated factors

Author(s) :

Alidjinou, Enagnon Kazali [Auteur]
Deldalle, J. [Auteur]
Robineau, Olivier [Auteur]
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Hallaert, C. [Auteur]
Meybeck, Agnes [Auteur]
Huleux, Thomas [Auteur]
Ajana, Faiza [Auteur]
Hober, Didier [Auteur]
Pathogenèse virale du diabète de type 1 - ULR 3610 [Laboratoire de Virologie]
Bocket, Laurence [Auteur]
Pathogenèse virale du diabète de type 1 - ULR 3610 [Laboratoire de Virologie]

Journal title :

Journal of medical virology

Abbreviated title :

J. Med. Virol.

Publication date :

2019-03-30

ISSN :

1096-9071

English keyword(s) :

hypermutation
drug resistance
HIV-1 DNA
stop codons
sequencing
mutations

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

We investigated the presence of stop codons (SC) and/or hypermutation (HM) in HIV-1 DNA sequences generated for routine drug resistance testing in proviral HIV-1 DNA, and sought for associated factors. At least one SC was ...
Show more >We investigated the presence of stop codons (SC) and/or hypermutation (HM) in HIV-1 DNA sequences generated for routine drug resistance testing in proviral HIV-1 DNA, and sought for associated factors. At least one SC was identified in 6.2% of HIV-1 DNA sequences, among which 54.8% were hypermutated. The defective virus group (SC w/o HM) was similar to the non-SC group regarding the characteristics of HIV-1 infection, and before drug exposure. In addition, the HIV-1 DNA levels were not different between both groups. Sequences with SC/HM displayed a higher proportion of RAMs. The impact of the SC/HM associated RAMs on clinical responses requires further investigation.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
Université de Lille

Collections :

• METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
• Pathogenèse virale du diabète de type 1 - ULR 3610

Submission date :

2019-12-09T16:54:41Z