Signet ring cells and efficacy of first-line ...
Type de document :
Article dans une revue scientifique: Article original
PMID :
URL permanente :
Titre :
Signet ring cells and efficacy of first-line chemotherapy in advanced gastric or oesogastric junction adenocarcinoma
Auteur(s) :
Lemoine, Nathalie [Auteur]
Adenis, Antoine [Auteur]
Bouche, Olivier [Auteur]
Duhamel, Alain [Auteur]
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Heurgue, Alexandra [Auteur]
Leteurtre, Emmanuelle [Auteur]
Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer (JPArc) - U1172
Amela, Eric Yaovi [Auteur]
Salleron, Julia [Auteur]
Hebbar, Mohamed [Auteur]
Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer (JPArc) - U1172
Adenis, Antoine [Auteur]
Bouche, Olivier [Auteur]
Duhamel, Alain [Auteur]
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Heurgue, Alexandra [Auteur]
Leteurtre, Emmanuelle [Auteur]
Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer (JPArc) - U1172
Amela, Eric Yaovi [Auteur]
Salleron, Julia [Auteur]
Hebbar, Mohamed [Auteur]
Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer (JPArc) - U1172
Titre de la revue :
Anticancer research
Nom court de la revue :
Anticancer Res.
Numéro :
36
Pagination :
5543-5549
Date de publication :
2016-10-01
ISSN :
0250-7005
Mot(s)-clé(s) en anglais :
prognosis
oesogastric junction adenocarcinoma
gastric adenocarcinoma
Signet ring cells
oesogastric junction adenocarcinoma
gastric adenocarcinoma
Signet ring cells
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
To evaluate the efficacy of first-line palliative chemotherapy, regarding the presence of signet ring cells (SRC).
Retrospective analysis of consecutive patients with locally advanced or metastatic gastric or oesogastric ...
Lire la suite >To evaluate the efficacy of first-line palliative chemotherapy, regarding the presence of signet ring cells (SRC). Retrospective analysis of consecutive patients with locally advanced or metastatic gastric or oesogastric junction adenocarcinoma who received first-line chemotherapy. Response to chemotherapy, progression-free survival (PFS) and overall survival (OS) were compared between SRC and non-SRC (NSRC) groups. Two hundred and three patients were treated, with 57 (28%) having SRC adenocarcinoma. Objective response rate was significantly lower in SRC patients (5.3% vs. 28.1%, p=0.0004). PFS was not significantly different between SRC and NSRC patients (median=3.8 vs. 4.9 months, p=0.07). OS was significantly shorter in SRC patients (median=5.6 vs. 9.4 months, p<0.008). In multivariate analysis SRC was not an independent prognostic factor for OS (hazard ratio (HR)=1.28, p=0.15). Patients with advanced SRC adenocarcinomas seemed to benefit less from chemotherapy, whereas the presence of SRC was not an independent survival prognostic factor.Lire moins >
Lire la suite >To evaluate the efficacy of first-line palliative chemotherapy, regarding the presence of signet ring cells (SRC). Retrospective analysis of consecutive patients with locally advanced or metastatic gastric or oesogastric junction adenocarcinoma who received first-line chemotherapy. Response to chemotherapy, progression-free survival (PFS) and overall survival (OS) were compared between SRC and non-SRC (NSRC) groups. Two hundred and three patients were treated, with 57 (28%) having SRC adenocarcinoma. Objective response rate was significantly lower in SRC patients (5.3% vs. 28.1%, p=0.0004). PFS was not significantly different between SRC and NSRC patients (median=3.8 vs. 4.9 months, p=0.07). OS was significantly shorter in SRC patients (median=5.6 vs. 9.4 months, p<0.008). In multivariate analysis SRC was not an independent prognostic factor for OS (hazard ratio (HR)=1.28, p=0.15). Patients with advanced SRC adenocarcinomas seemed to benefit less from chemotherapy, whereas the presence of SRC was not an independent survival prognostic factor.Lire moins >
Langue :
Anglais
Audience :
Internationale
Vulgarisation :
Non
Établissement(s) :
CHU Lille
Inserm
Université de Lille
Inserm
Université de Lille
Collections :
Date de dépôt :
2019-12-09T18:15:34Z
2021-06-15T11:53:47Z
2021-06-15T11:53:47Z