Titre :

Measuring senescence rates of patients with end-stage renal disease while accounting for population heterogeneity: an analysis of data from the era-edta registry

Auteur(s) :

Koopman, Jacob J E. [Auteur]
Kramer, Anneke [Auteur]
Van Heemst, Diana [Auteur]
Asberg, Anders [Auteur]
BEUSCART, Jean-Baptiste [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Buturovic-Ponikvar, Jadranka [Auteur]
Collart, Frederic [Auteur]
Couchoud, Cecile G. [Auteur]
Finne, Patrik [Auteur]
Heaf, James G. [Auteur]
Massy, Ziad A. [Auteur]
De Meester, Johan M J. [Auteur]
Palsson, Runolfur [Auteur]
Steenkamp, Retha [Auteur]
Traynor, Jamie P. [Auteur]
Jager, Kitty J. [Auteur]
Putter, Hein [Auteur]

Titre de la revue :

Annals of epidemiology

Nom court de la revue :

Ann. Epidemiol.

Numéro :

26

Pagination :

773-779

Date de publication :

2016-11-01

ISSN :

1047-2797

Mot(s)-clé(s) en anglais :

Gompertz model
Aging
Dialysis
End-stage renal disease
Frailty
Senescence
Population heterogeneity
Mortality rate
Kidney transplantation
Senescence rate

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Although a population's senescence rate is classically measured as the increase in mortality rate with age on a logarithmic scale, it may be more accurately measured as the increase on a linear scale. Patients on dialysis, ...
Lire la suite >Although a population's senescence rate is classically measured as the increase in mortality rate with age on a logarithmic scale, it may be more accurately measured as the increase on a linear scale. Patients on dialysis, who suffer from accelerated senescence, exhibit a smaller increase in their mortality rate on a logarithmic scale, but a larger increase on a linear scale than patients with a functioning kidney transplant. However, this comparison may be biased by population heterogeneity. Follow-up data on 323,308 patients on dialysis and 91,679 patients with a functioning kidney transplant were derived from the ERA-EDTA Registry. We measured the increases in their mortality rates using Gompertz frailty models that allow individual variation in this increase. According to these models, the senescence rate measured as the increase in mortality rate on a logarithmic scale was smaller in patients on dialysis, while the senescence rate measured as the increase on a linear scale was larger in patients on dialysis than patients with a functioning kidney transplant. Also when accounting for population heterogeneity, a population's senescence rate is more accurately measured as the increase in mortality rate on a linear scale than a logarithmic scale.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

CHU Lille
Université de Lille

Collections :

• METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694

Date de dépôt :

2019-12-09T18:15:36Z