Title :

Specificities of ischemic stroke risk factors in arab-speaking countries

Author(s) :

Abboud, Halim [Auteur]
Sissani, Leila [Auteur]
Labreuche, Julien [Auteur]
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Arauz, Antonio [Auteur]
Bousser, Marie-Germaine [Auteur]
Bryer, Alain [Auteur]
Chamorro, Angel [Auteur]
Fisher, Marc [Auteur]
Ford, Ian [Auteur]
Fox, Kim M. [Auteur]
Hennerici, Michael G. [Auteur]
Lavados, Pablo M. [Auteur]
Massaro, Ayrton [Auteur]
Mattle, Heinrich P. [Auteur]
Munoz Collazos, Mario [Auteur]
Rothwell, Peter M. [Auteur]
Steg, Philippe Gabriel [Auteur]
Vicaut, Eric [Auteur]
Yamouth, Bassem [Auteur]
Amarenco, Pierre [Auteur]

Journal title :

Cerebrovascular diseases (Basel, Switzerland)

Abbreviated title :

Cerebrovasc. Dis.

Volume number :

43

Pages :

169-177

Publication date :

2017-01-01

ISSN :

1015-9770

English keyword(s) :

Risk factors
Stroke
TIA
Socio-economic status

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Stroke is largely preventable, and therefore, a better understanding of risk factors is an essential step in reducing the population stroke rate and resulting disease burden in Arab countries. We performed 2 separate ...
Show more >Stroke is largely preventable, and therefore, a better understanding of risk factors is an essential step in reducing the population stroke rate and resulting disease burden in Arab countries. We performed 2 separate analyses in 2 similar populations of patients with noncardioembolic ischemic stroke. This first involved 3,635 patients in the Outcomes in Patients with TIA and Cerebrovascular disease (OPTIC) registry (followed for 2 years), with baseline collection of the usual risk factors and 5 socioeconomic variables (unemployment status, residence in rural area, living in fully serviced accommodation, no health-insurance coverage, and low educational level). The second involved patients in the PERFORM trial (n = 19,100 followed up for 2 years), with baseline collection of the usual risk factors and 1 socioeconomic variable (low educational level). The primary outcome was a composite of nonfatal stroke, nonfatal myocardial infarction, or cardiovascular death. Stroke risk factors were more prevalent in patients in Arab countries. The incidence of major cardiovascular events (MACE; age- and gender-adjusted) was higher in Arab countries (OPTIC, 18.5 vs. 13.3%; PERFORM, 18.4 vs. 9.7%; both p ≤ 0.0001). These results remained significant after adjustment on risk factors and were attenuated in OPTIC after further adjustment on socioeconomic variables (hazard ratio 1.24; 95% CI 0.98-1.55; p = 0.07). Key Messages: Patients with ischemic stroke living in Arab countries had a lower mean socioeconomic status, a much higher prevalence of diabetes mellitus, and a higher rate of MACE compared with patients from non-Arab countries. This finding is partly explained by a higher prevalence of risk factors and also by a high prevalence of poverty and low educational level.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
Université de Lille

Collections :

• METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694

Submission date :

2019-12-09T18:16:20Z