Title :

Complication-related removal of totally implantable venous access port systems: does the interval between placement and first use and the neutropenia-inducing potential of chemotherapy regimens influence their incidence? a four-year prospective study of 4045 patients

Author(s) :

Kakkos, A. [Auteur]
Bresson, L. [Auteur]
Hudry, D. [Auteur]
Cousin, Sophie [Auteur]
Lervat, Cyril [Auteur]
Bogart, Emilie [Auteur]
Meurant, Jean-Pierre [Auteur]
El Bedoui, Sophie [Auteur]
Decanter, Gauthier [Auteur]
Hannebicque, Karine [Auteur]
Regis, C. [Auteur]
Hamdani, A. [Auteur]
Penel, Nicolas [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Tresch-Bruneel, Emmanuelle [Auteur]
Narducci, F. [Auteur]

Journal title :

European journal of surgical oncology . the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

Abbreviated title :

EJSO

Volume number :

43

Pages :

689-695

Publication date :

2017-04-01

ISSN :

0748-7983

English keyword(s) :

Neutropenia-inducing potential of chemotherapy
Removal for complications
Totally implantable venous access port systems
Interval insertion-first use

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

BACKGROUND: Totally implantable venous access port systems are widely used in oncology, with frequent complications that sometimes necessitate device removal. The aim of this study is to investigate the impact of the time ...
Show more >BACKGROUND: Totally implantable venous access port systems are widely used in oncology, with frequent complications that sometimes necessitate device removal. The aim of this study is to investigate the impact of the time interval between port placement and initiation of chemotherapy and the neutropenia-inducing potential of the chemotherapy administered upon complication-related port removal. METHODS: Between January 2010 and December 2013, 4045 consecutive patients were included in this observational, single-center prospective study. The chemotherapy regimens were classified as having a low (<10%), intermediate (10-20%), or high (>20%) risk for inducing neutropenia. RESULTS: The overall removal rate due to complications was 7.2%. Among them, port-related infection (2.5%) and port expulsion (1%) were the most frequent. The interval between port insertion and its first use was shown to be a predictive factor for complication-related removal rates. A cut-off of 6 days was statistically significant (p = 0.008), as the removal rate for complications was 9.4% when this interval was 0-5 days and 5.7% when it was ≥6 days. Another factor associated with port complication rate was the neutropenia-inducing potential of the chemotherapy regimens used, with removal for complications involved in 5.5% of low-risk regimens versus 9.4% for the intermediate- and high-risk regimens (p = 0.003). CONCLUSIONS: An interval of 6 days between placement and first use of the port reduces the removal rate from complications. The intermediate- and high-risk for neutropenia chemotherapy regimens are related to higher port removal rates from complications than low-risk regimens.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
Université de Lille

Collections :

• METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694

Submission date :

2019-12-09T18:16:22Z
2021-06-10T15:12:17Z