Development of a core outcome set for ...
Document type :
Article dans une revue scientifique: Article de synthèse/Review paper
DOI :
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Title :
Development of a core outcome set for medication review in older patients with multimorbidity and polypharmacy: a study protocol
Author(s) :
BEUSCART, Jean-Baptiste [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Université Catholique de Louvain = Catholic University of Louvain [UCL]
Dalleur, Olivia [Auteur]
Université Catholique de Louvain = Catholic University of Louvain [UCL]
Boland, Benoit [Auteur]
Cliniques Universitaires Saint-Luc [Bruxelles]
Thevelin, Stefanie [Auteur]
Université Catholique de Louvain = Catholic University of Louvain [UCL]
Knol, Wilma [Auteur]
University Medical Center [Utrecht] [UMCU]
Cullinan, Shane [Auteur]
Royal College of Surgeons in Ireland [RCSI]
Schneider, Claudio [Auteur]
Bern University Hospital [Berne] [Inselspital]
O'mahony, Denis [Auteur]
University College Cork [UCC]
Rodondi, Nicolas [Auteur]
Royal College of Surgeons in Ireland [RCSI]
Spinewine, Anne [Auteur]
Université Catholique de Louvain = Catholic University of Louvain [UCL]

METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Université Catholique de Louvain = Catholic University of Louvain [UCL]
Dalleur, Olivia [Auteur]
Université Catholique de Louvain = Catholic University of Louvain [UCL]
Boland, Benoit [Auteur]
Cliniques Universitaires Saint-Luc [Bruxelles]
Thevelin, Stefanie [Auteur]
Université Catholique de Louvain = Catholic University of Louvain [UCL]
Knol, Wilma [Auteur]
University Medical Center [Utrecht] [UMCU]
Cullinan, Shane [Auteur]
Royal College of Surgeons in Ireland [RCSI]
Schneider, Claudio [Auteur]
Bern University Hospital [Berne] [Inselspital]
O'mahony, Denis [Auteur]
University College Cork [UCC]
Rodondi, Nicolas [Auteur]
Royal College of Surgeons in Ireland [RCSI]
Spinewine, Anne [Auteur]
Université Catholique de Louvain = Catholic University of Louvain [UCL]
Journal title :
Clinical interventions in aging
Abbreviated title :
Clin. Interv. Aging
Volume number :
12
Pages :
1379-1389
Publication date :
2017-01-01
ISSN :
1178-1998
English keyword(s) :
multimorbidity
polypharmacy
core outcome set
study protocol
Mesh:Clinical Trials as Topic/standards*
Mesh:Surveys and Questionnaires
Mesh:Research Design
Mesh:Polypharmacy*
Mesh:Multimorbidity*
Mesh:Medication Therapy Management/standards*
Mesh:Humans
Mesh:Delphi Technique
Mesh:Aged
polypharmacy
core outcome set
study protocol
Mesh:Clinical Trials as Topic/standards*
Mesh:Surveys and Questionnaires
Mesh:Research Design
Mesh:Polypharmacy*
Mesh:Multimorbidity*
Mesh:Medication Therapy Management/standards*
Mesh:Humans
Mesh:Delphi Technique
Mesh:Aged
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
BACKGROUND: Medication review has been advocated to address the challenge of polypharmacy in older patients, yet there is no consensus on how best to evaluate its efficacy. Heterogeneity of outcomes reported in clinical ...
Show more >BACKGROUND: Medication review has been advocated to address the challenge of polypharmacy in older patients, yet there is no consensus on how best to evaluate its efficacy. Heterogeneity of outcomes reported in clinical trials can hinder the comparison of clinical trial findings in systematic reviews. Moreover, the outcomes that matter most to older patients might be under-reported or disregarded altogether. A core outcome set can address this issue as it defines a minimum set of outcomes that should be reported in all clinical trials in any particular field of research. As part of the European Commission-funded project, called OPtimising thERapy to prevent Avoidable hospital admissions in the Multimorbid elderly, this paper describes the methods used to develop a core outcome set for clinical trials of medication review in older patients with multimorbidity. METHODS: The study was designed in several steps. First, a systematic review established which outcomes were measured in published and ongoing clinical trials of medication review in older patients. Second, we undertook semistructured interviews with older patients and carers aimed at identifying additional relevant outcomes. Then, a multilanguage European Delphi survey adapted to older patients was designed. The international Delphi survey was conducted with older patients, health care professionals, researchers, and clinical experts in geriatric pharmacotherapy to validate outcomes to be included in the core outcome set. Consensus meetings were conducted to validate the results. CONCLUSIONS: We present the method for developing a core outcome set for medication review in older patients with multimorbidity. This study protocol could be used as a basis to develop core outcome sets in other fields of geriatric research.Show less >
Show more >BACKGROUND: Medication review has been advocated to address the challenge of polypharmacy in older patients, yet there is no consensus on how best to evaluate its efficacy. Heterogeneity of outcomes reported in clinical trials can hinder the comparison of clinical trial findings in systematic reviews. Moreover, the outcomes that matter most to older patients might be under-reported or disregarded altogether. A core outcome set can address this issue as it defines a minimum set of outcomes that should be reported in all clinical trials in any particular field of research. As part of the European Commission-funded project, called OPtimising thERapy to prevent Avoidable hospital admissions in the Multimorbid elderly, this paper describes the methods used to develop a core outcome set for clinical trials of medication review in older patients with multimorbidity. METHODS: The study was designed in several steps. First, a systematic review established which outcomes were measured in published and ongoing clinical trials of medication review in older patients. Second, we undertook semistructured interviews with older patients and carers aimed at identifying additional relevant outcomes. Then, a multilanguage European Delphi survey adapted to older patients was designed. The international Delphi survey was conducted with older patients, health care professionals, researchers, and clinical experts in geriatric pharmacotherapy to validate outcomes to be included in the core outcome set. Consensus meetings were conducted to validate the results. CONCLUSIONS: We present the method for developing a core outcome set for medication review in older patients with multimorbidity. This study protocol could be used as a basis to develop core outcome sets in other fields of geriatric research.Show less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
CHU Lille
Université de Lille
Université de Lille
Submission date :
2019-12-09T18:17:08Z
2020-05-27T10:20:49Z
2020-05-27T12:07:30Z
2020-05-27T10:20:49Z
2020-05-27T12:07:30Z
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