Titre :

Metastasis-free interval in breast cancer patients: thirty-year trends and time dependency of prognostic factors. A retrospective analysis based on a single institution experience

Auteur(s) :

Houze De L'aulnoit, Agathe [Auteur]
Groupement des Hôpitaux de l'Institut Catholique de Lille [GHICL]
Rogoz, Bianca [Auteur]
Groupement des Hôpitaux de l'Institut Catholique de Lille [GHICL]
Pinçon, Claire [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Houze De L'aulnoit, Denis [Auteur]
Groupement des Hôpitaux de l'Institut Catholique de Lille [GHICL]

Titre de la revue :

The Breast

Nom court de la revue :

Breast

Numéro :

37

Pagination :

80-88

Date de publication :

2018-02

ISSN :

0960-9776

Mot(s)-clé(s) en anglais :

Prognostic factors
Metastasis-free interval
Breast cancer
Cox model

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

BACKGROUND: Breast cancer remains the leading cause of cancer death in French women in spite of continuously improving management. The objectives of this study were to analyse trends in the metastasis-free interval over ...
Lire la suite >BACKGROUND: Breast cancer remains the leading cause of cancer death in French women in spite of continuously improving management. The objectives of this study were to analyse trends in the metastasis-free interval over the past 30 years and to identify the prognostic factors of survival, while accounting for time dependency. METHODS: A total of 1613 patients diagnosed with invasive non-metastatic breast cancer at Saint Vincent de Paul Hospital, Lille, France between 1977 and 2013, were followed for outcome (metastasis-free interval). Cohort entry time delay, a continuous temporal covariate, was defined to assess improvement of outcome. Data were analysed using the Cox proportional hazards model and presented as hazard ratio (HR). RESULTS: Metastatic disease developed during follow-up in 446 (27.6%) patients. Cohort entry time delay exhibited strong independent prognostic value while accounting for multiple prognostic factors including: tumour size (HR = 1.62, 95 %CI 1.37-1.91); rapid tumour growth (HR = 1.59, 95%CI 1.17-2.16); lymph node ratio (HR = 2.29, 95%CI 1.97-2.66); histological grade (grade 2 was significant only during the first 10 years after diagnosis, grade 3 and progesterone receptor status only during the first 5 years after diagnosis); and oestrogen receptor status (significant only during the first 8 years (HR = 0.75, 95%CI 0.58-0.96)). CONCLUSIONS: The current study showed an improvement in the prognosis of breast cancer patients over the past 30 years and pointed to the importance of evaluating covariates with time-varying effects.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

CHU Lille
Université de Lille

Collections :

• METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694

Date de dépôt :

2019-12-09T18:17:39Z
2024-05-22T12:58:34Z