International core outcome set for clinical ...
Document type :
Article dans une revue scientifique: Article de synthèse/Review paper
PMID :
Permalink :
Title :
International core outcome set for clinical trials of medication review in multi-morbid older patients with polypharmacy
Author(s) :
BEUSCART, Jean-Baptiste [Auteur]
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Knol, Wilma [Auteur]
University Medical Center [Utrecht] [UMCU]
Cullinan, Shane [Auteur]
Royal College of Surgeons in Ireland [RCSI]
University College Cork [UCC]
Schneider, Claudio [Auteur]
Bern University Hospital [Berne] [Inselspital]
Dalleur, Olivia [Auteur]
Université Catholique de Louvain = Catholic University of Louvain [UCL]
Cliniques Universitaires Saint-Luc [Bruxelles]
Boland, Benoit [Auteur]
Cliniques Universitaires Saint-Luc [Bruxelles]
Thevelin, Stefanie [Auteur]
Université Catholique de Louvain = Catholic University of Louvain [UCL]
Jansen, Paul A. F. [Auteur]
University Medical Center [Utrecht] [UMCU]
O'mahony, Denis [Auteur]
University College Cork [UCC]
Rodondi, Nicolas [Auteur]
Bern University Hospital [Berne] [Inselspital]
Spinewine, Anne [Auteur]
Université Catholique de Louvain = Catholic University of Louvain [UCL]
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Knol, Wilma [Auteur]
University Medical Center [Utrecht] [UMCU]
Cullinan, Shane [Auteur]
Royal College of Surgeons in Ireland [RCSI]
University College Cork [UCC]
Schneider, Claudio [Auteur]
Bern University Hospital [Berne] [Inselspital]
Dalleur, Olivia [Auteur]
Université Catholique de Louvain = Catholic University of Louvain [UCL]
Cliniques Universitaires Saint-Luc [Bruxelles]
Boland, Benoit [Auteur]
Cliniques Universitaires Saint-Luc [Bruxelles]
Thevelin, Stefanie [Auteur]
Université Catholique de Louvain = Catholic University of Louvain [UCL]
Jansen, Paul A. F. [Auteur]
University Medical Center [Utrecht] [UMCU]
O'mahony, Denis [Auteur]
University College Cork [UCC]
Rodondi, Nicolas [Auteur]
Bern University Hospital [Berne] [Inselspital]
Spinewine, Anne [Auteur]
Université Catholique de Louvain = Catholic University of Louvain [UCL]
Journal title :
BMC medicine
Abbreviated title :
BMC Med.
Volume number :
16
Publication date :
2018-02-13
ISSN :
1741-7015
English keyword(s) :
Consensus
Delphi survey
Polypharmacy
Multi-morbidity
Older patients
Medication review
Core outcome set
Mesh:Quality of Life/psychology*
Mesh:Surveys and Questionnaires
Mesh:Aged
Mesh:Comorbidity
Mesh:Delphi Technique
Mesh:Humans
Mesh:Medication Adherence
Mesh:Polypharmacy*
Delphi survey
Polypharmacy
Multi-morbidity
Older patients
Medication review
Core outcome set
Mesh:Quality of Life/psychology*
Mesh:Surveys and Questionnaires
Mesh:Aged
Mesh:Comorbidity
Mesh:Delphi Technique
Mesh:Humans
Mesh:Medication Adherence
Mesh:Polypharmacy*
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
Comparisons of clinical trial findings in systematic reviews can be hindered by the heterogeneity of the outcomes reported. Moreover, the outcomes that matter most to patients might be underreported. A core outcome set can ...
Show more >Comparisons of clinical trial findings in systematic reviews can be hindered by the heterogeneity of the outcomes reported. Moreover, the outcomes that matter most to patients might be underreported. A core outcome set can address these issues, as it defines a minimum set of outcomes that should be reported in all clinical trials in a particular area of research. The objective in this study was to develop a core outcome set for clinical trials of medication review in multi-morbid older patients with polypharmacy. Firstly, eligible outcomes were identified through a systematic review of trials of medication review in older patients (≥65 years) and interviews with 15 older patients. Secondly, an international three-round Delphi survey in four countries involving patients, healthcare professionals, and experts was conducted to validate outcomes to be included in the core outcome set. Consensus meetings were conducted to validate the results. Of the 164 participants invited to take part in the Delphi survey, 150 completed Round 1, including 55 patients or family caregivers, 55 healthcare professionals, and 40 experts. A total of 129 participants completed all three rounds. Sixty-four eligible outcomes were extracted from 47 articles, 32 clinical trial protocols, and patient interviews. Thirty outcomes were removed and one added after Round 1, 18 outcomes were removed after Round 2, and seven after Round 3. Results were discussed during consensus meetings. Consensus was reached on seven outcomes, which constitute the core outcome set: drug-related hospital admissions; drug overuse; drug underuse; potentially inappropriate medications; clinically significant drug-drug interactions; health-related quality of life; pain relief. We developed a core outcome set of seven outcomes which should be used in future trials of medication review in multi-morbid older patients with polypharmacy.Show less >
Show more >Comparisons of clinical trial findings in systematic reviews can be hindered by the heterogeneity of the outcomes reported. Moreover, the outcomes that matter most to patients might be underreported. A core outcome set can address these issues, as it defines a minimum set of outcomes that should be reported in all clinical trials in a particular area of research. The objective in this study was to develop a core outcome set for clinical trials of medication review in multi-morbid older patients with polypharmacy. Firstly, eligible outcomes were identified through a systematic review of trials of medication review in older patients (≥65 years) and interviews with 15 older patients. Secondly, an international three-round Delphi survey in four countries involving patients, healthcare professionals, and experts was conducted to validate outcomes to be included in the core outcome set. Consensus meetings were conducted to validate the results. Of the 164 participants invited to take part in the Delphi survey, 150 completed Round 1, including 55 patients or family caregivers, 55 healthcare professionals, and 40 experts. A total of 129 participants completed all three rounds. Sixty-four eligible outcomes were extracted from 47 articles, 32 clinical trial protocols, and patient interviews. Thirty outcomes were removed and one added after Round 1, 18 outcomes were removed after Round 2, and seven after Round 3. Results were discussed during consensus meetings. Consensus was reached on seven outcomes, which constitute the core outcome set: drug-related hospital admissions; drug overuse; drug underuse; potentially inappropriate medications; clinically significant drug-drug interactions; health-related quality of life; pain relief. We developed a core outcome set of seven outcomes which should be used in future trials of medication review in multi-morbid older patients with polypharmacy.Show less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
CHU Lille
Université de Lille
Université de Lille
Submission date :
2019-12-09T18:17:50Z
2020-04-15T08:32:12Z
2020-04-15T08:32:12Z
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