Large sporadic thyroid medullary carcinomas: ...
Type de document :
Article dans une revue scientifique: Article original
PMID :
URL permanente :
Titre :
Large sporadic thyroid medullary carcinomas: predictive factors for lymph node involvement
Auteur(s) :
Aubert, Sebastien [Auteur]
374570|||Université de Lille (VALID)
575611|||Institut de Pathologie [CHU Lille] (VALID)
Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer (JPArc) - U1172
Berdelou, Amandine [Auteur]
Gnemmi, Viviane [Auteur]
374570|||Université de Lille (VALID)
575611|||Institut de Pathologie [CHU Lille] (VALID)
Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer (JPArc) - U1172
Behal, Helene [Auteur]
221576|||Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS] (VALID)
Service de Biostatistiques [CHRU Lille]
Caiazzo, Robert [Auteur]
Université de Lille
Service de chirurgie générale et endocrinienne
D' Herbomez, Michèle [Auteur]
Pigny, Pascal [Auteur]
Université de Lille
Institut de Biochimie et Biologie Moléculaire [CHRU Lille]
Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer (JPArc) - U1172
Wemeau, Jean Louis [Auteur]
Carnaille, Bruno [Auteur]
Service de chirurgie générale et endocrinienne
Université de Lille
Renaud, Florence [Auteur]
Université de Lille
Institut de Pathologie [CHU Lille]
Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer (JPArc) - U1172
Bouchindhomme, Brigitte [Auteur]
Leteurtre, Emmanuelle [Auteur]
Université de Lille
Institut de Pathologie [CHU Lille]
Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer (JPArc) - U1172
Perrais, Michael [Auteur]
Université de Lille
Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer (JPArc) - U1172
Pattou, Francois [Auteur]
Service de chirurgie générale et endocrinienne
Université de Lille
Do Cao, Christine [Auteur]
374570|||Université de Lille (VALID)
575611|||Institut de Pathologie [CHU Lille] (VALID)
Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer (JPArc) - U1172
Berdelou, Amandine [Auteur]
Gnemmi, Viviane [Auteur]
374570|||Université de Lille (VALID)
575611|||Institut de Pathologie [CHU Lille] (VALID)
Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer (JPArc) - U1172
Behal, Helene [Auteur]
221576|||Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS] (VALID)
Service de Biostatistiques [CHRU Lille]
Caiazzo, Robert [Auteur]
Université de Lille
Service de chirurgie générale et endocrinienne
D' Herbomez, Michèle [Auteur]
Pigny, Pascal [Auteur]
Université de Lille
Institut de Biochimie et Biologie Moléculaire [CHRU Lille]
Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer (JPArc) - U1172
Wemeau, Jean Louis [Auteur]
Carnaille, Bruno [Auteur]
Service de chirurgie générale et endocrinienne
Université de Lille
Renaud, Florence [Auteur]
Université de Lille
Institut de Pathologie [CHU Lille]
Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer (JPArc) - U1172
Bouchindhomme, Brigitte [Auteur]
Leteurtre, Emmanuelle [Auteur]
Université de Lille
Institut de Pathologie [CHU Lille]
Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer (JPArc) - U1172
Perrais, Michael [Auteur]
Université de Lille
Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer (JPArc) - U1172
Pattou, Francois [Auteur]
Service de chirurgie générale et endocrinienne
Université de Lille
Do Cao, Christine [Auteur]
Titre de la revue :
Virchows Archiv
Nom court de la revue :
Virchows Arch.
Numéro :
472
Pagination :
461–468
Éditeur :
Springer Verlag
Date de publication :
2018-02-01
ISSN :
0945-6317
Mot(s)-clé(s) en anglais :
Medullary
Desmoplasia
Node
Thyroid
Carcinoma
MicroRNA
Desmoplasia
Node
Thyroid
Carcinoma
MicroRNA
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
Lymph node involvement (LNI) is one of the most important prognostic factors for poor survival in medullary thyroid carcinoma (MTC). At diagnosis, LNI is found in over 50% of sporadic MTCs, and especially in large tumours. ...
Lire la suite >Lymph node involvement (LNI) is one of the most important prognostic factors for poor survival in medullary thyroid carcinoma (MTC). At diagnosis, LNI is found in over 50% of sporadic MTCs, and especially in large tumours. Cervical lymph node dissection is therefore mandatory during MTC surgery. However, some large tumours (responsible for high preoperative basal calcitonin levels) are found to lack LNI, and can be cured definitely. Preoperative detection of these particular tumours might spare patients from undergoing extensive cervical dissection. The objective of the present retrospective study of a series of large sporadic MTCs was to identify clinical, biological and pathological factors that were predictive of LNI. Consecutive cases of large, sporadic MTCs (measuring at least 1 cm in diameter) were retrieved and reviewed. The levels of several mature microRNAs (miRs) in paraffin-embedded samples were assessed using qPCR. Of the 54 MTCs, 26 had LNI and 28 were pN0. Relative to pN0 patients, patients with LNI had a significant higher preoperative basal calcitonin level (p = 0.0074) and a greater prevalence of infiltrative margins (p < 0.0001), lymphovascular invasion (p = 0.0004), extrathyroidal extension (p < 0.0001), a higher pT stage (p = 0.0003) and more abundant desmoplastic stroma (p = 0.0006). Tumour expression levels of miR-21 (p = 0.0008) and miR-183 (p = 0.0096) were higher in the LNI group. The abundance of desmoplastic stroma (p = 0.007) and the miR-21 expression level (p = 0.0026) were independent prognostic factors for LNI. The abundance of desmoplastic stroma and high levels of miR-21 expression were strong indicators of LNI, and may thus help the surgeon to choose the extent of cervical lymph node dissection for large, sporadic MTCs with no preoperatively obvious LNI.Lire moins >
Lire la suite >Lymph node involvement (LNI) is one of the most important prognostic factors for poor survival in medullary thyroid carcinoma (MTC). At diagnosis, LNI is found in over 50% of sporadic MTCs, and especially in large tumours. Cervical lymph node dissection is therefore mandatory during MTC surgery. However, some large tumours (responsible for high preoperative basal calcitonin levels) are found to lack LNI, and can be cured definitely. Preoperative detection of these particular tumours might spare patients from undergoing extensive cervical dissection. The objective of the present retrospective study of a series of large sporadic MTCs was to identify clinical, biological and pathological factors that were predictive of LNI. Consecutive cases of large, sporadic MTCs (measuring at least 1 cm in diameter) were retrieved and reviewed. The levels of several mature microRNAs (miRs) in paraffin-embedded samples were assessed using qPCR. Of the 54 MTCs, 26 had LNI and 28 were pN0. Relative to pN0 patients, patients with LNI had a significant higher preoperative basal calcitonin level (p = 0.0074) and a greater prevalence of infiltrative margins (p < 0.0001), lymphovascular invasion (p = 0.0004), extrathyroidal extension (p < 0.0001), a higher pT stage (p = 0.0003) and more abundant desmoplastic stroma (p = 0.0006). Tumour expression levels of miR-21 (p = 0.0008) and miR-183 (p = 0.0096) were higher in the LNI group. The abundance of desmoplastic stroma (p = 0.007) and the miR-21 expression level (p = 0.0026) were independent prognostic factors for LNI. The abundance of desmoplastic stroma and high levels of miR-21 expression were strong indicators of LNI, and may thus help the surgeon to choose the extent of cervical lymph node dissection for large, sporadic MTCs with no preoperatively obvious LNI.Lire moins >
Langue :
Anglais
Comité de lecture :
Oui
Audience :
Internationale
Vulgarisation :
Non
Établissement(s) :
CHU Lille
Inserm
Université de Lille
Inserm
Université de Lille
Collections :
Date de dépôt :
2019-12-09T18:18:05Z
2021-06-15T12:29:23Z
2024-04-30T13:46:03Z
2021-06-15T12:29:23Z
2024-04-30T13:46:03Z