Title :

Prognostic performance of early absence of pupillary light reaction after recovery of out of hospital cardiac arrest

Author(s) :

Javaudin, François [Auteur]
Microbiotes, Hôtes, Antibiotiques et Résistances bactériennes (MiHAR) [MiHAR]
Leclere, Brice [Auteur]
Microbiotes, Hôtes, Antibiotiques et Résistances bactériennes (MiHAR) [MiHAR]
Segard, J. [Auteur]
Centre Hospitalier Universitaire de Nantes = Nantes University Hospital [CHU Nantes]
Le Bastard, Q [Auteur]
Microbiotes, Hôtes, Antibiotiques et Résistances bactériennes (MiHAR) [MiHAR]
Pes, P. [Auteur]
Centre Hospitalier Universitaire de Nantes = Nantes University Hospital [CHU Nantes]
Penverne, Y. [Auteur]
Centre Hospitalier Universitaire de Nantes = Nantes University Hospital [CHU Nantes]
Le Conte, Philippe [Auteur]
Centre Hospitalier Universitaire de Nantes = Nantes University Hospital [CHU Nantes]
Jenvrin, J. [Auteur]
Centre Hospitalier Universitaire de Nantes = Nantes University Hospital [CHU Nantes]
Hubert, Hervé [Auteur]
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Escutnaire, Josephine [Auteur]
Santé publique : épidémiologie et qualité des soins - EA 2694
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Batard, E. [Auteur]
Microbiotes, Hôtes, Antibiotiques et Résistances bactériennes (MiHAR) [MiHAR]
Montassier, Emmanuel [Auteur]
Microbiotes, Hôtes, Antibiotiques et Résistances bactériennes (MiHAR) [MiHAR]

Journal title :

Resuscitation

Abbreviated title :

Resuscitation

Volume number :

127

Pages :

8-13

Publication date :

2018-06

ISSN :

1873-1570

English keyword(s) :

Prognostication
Pupillary light reaction
Outcome
Out of hospital cardiac arrest

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Loss of pupillary light reactivity (PLR) three days after a cardiorespiratory arrest is a prognostic factor. Its predictive value upon hospital admission remains unclear. Our objective was to determine the prognostic value ...
Show more >Loss of pupillary light reactivity (PLR) three days after a cardiorespiratory arrest is a prognostic factor. Its predictive value upon hospital admission remains unclear. Our objective was to determine the prognostic value of the absence of PLR upon hospital admission in patients with out-of-hospital cardiac arrest. We prospectively included all out-of-hospital cardiac arrests occurring between July 2011 and July 2017 treated by a mobile medical team (MMT) based on data from a French cardiac arrest registry database. PLR was evaluated upon hospital admission and the outcome on day 30. The prognosis was classified as good for Cerebral Performance Category (CPC) 1 or 2, and poor for CPC 3-5 or in case of death. Data from 10151 patients was analysed. The sensitivity and specificity of the absence of PLR for a poor outcome were 72.2% (71.2-73.2) and 68.8% (66.7-70.1), respectively. We identified several variables modifying the sensitivity values and the false positive fraction of a factor, ranging from 0.49 (0.35-0.69) for the Glasgow Coma Scale to 2.17 (1.09-2.48) for pupillary asymmetry. Among those living with CPC 1 or 2 on day 30 (n = 1990; 19.6%), 621 (31.2% (29.2-33.3)) had no PLR upon hospital admission. In the multivariate analysis, loss of PLR was associated with a poor outcome (OR = 3.1 (2.7-3.5)). Loss of pupillary light reactivity upon hospital admission is predictive of a poor outcome after out-of-hospital cardiac arrest. However, it does not have sufficient accuracy to determine prognosis and decision making.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
Université de Lille

Collections :

• METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694

Submission date :

2019-12-09T18:18:22Z
2024-06-04T12:29:26Z