Title :

Management of red blood cell alloimmunization in pregnancy

Author(s) :

Ghesquière, Louise [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Garabedian, Charles [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Coulon, Capucine [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Verpillat, P. [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Rakza, Thameur [Auteur]
Environnement périnatal et croissance - EA 4489 [EPS]
Wibaut, B. [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Delsalle, Anne [Auteur]
Etablissement Français du Sang Hauts-de-France - Normandie [EFS Hauts-de-France - Normandie]
Subtil, Damien [Auteur]
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Vaast, Pascal [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Debarge, Veronique [Auteur]
Environnement périnatal et croissance - EA 4489 [EPS]
Environnement Périnatal et Santé - EA 4489

Journal title :

Journal of gynecology obstetrics and human reproduction

Abbreviated title :

J Gynecol Obstet Hum Reprod

Volume number :

47

Pages :

197-204

Publisher :

Elsevier

Publication date :

2018-02-21

ISSN :

2468-7847

English keyword(s) :

Alloimmunization
Fetal anemia
Hydrops
Intrauterine transfusion
Ultrasound

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

The main cause of fetal anemia is maternal red blood cell alloimmunization (AI). The search of maternal antibodies by indirect antiglobulin test allows screening for AI during pregnancy. In case of AI, fetal genotyping ...
Show more >The main cause of fetal anemia is maternal red blood cell alloimmunization (AI). The search of maternal antibodies by indirect antiglobulin test allows screening for AI during pregnancy. In case of AI, fetal genotyping (for Rh-D, Rh-c, Rh-E and Kell), quantification (for anti-rhesus antibodies) and antibody titration, as well as ultrasound monitoring, are performed. This surveillance aims at screening for severe anemia before hydrops fetalis occurs. Management of severe anemia is based on intrauterine transfusion (IUT) or labor induction depending on gestational age. After intrauterine transfusion, follow-up will focus on detecting recurrence of anemia and detecting fetal brain injury. With IUT, survival of fetuses with alloimmunization is greater than 90% but 4.8% of children with at least one IUT have neurodevelopmental impairment.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
Université de Lille

Collections :

• Environnement Périnatal et Santé - ULR 4489
• METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694

Submission date :

2019-12-09T18:18:38Z
2021-06-03T13:02:55Z
2024-03-06T10:26:19Z