Title :

Carotid stenting with antithrombotic agents and intracranial thrombectomy leads to the highest recanalization rate in patients with acute stroke with tandem lesions

Author(s) :

Papanagiotou, Panagiotis [Auteur]
Haussen, Diogo C. [Auteur]
Emory University School of Medicine
Turjman, Francis [Auteur]
Labreuche, Julien [Auteur]
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Piotin, Michel [Auteur]
Kastrup, Andreas [Auteur]
Steglich-Arnholm, Henrik [Auteur]
Holtmannspotter, Markus [Auteur]
Taschner, Christian [Auteur]
Eiden, Sebastian [Auteur]
Nogueira, Raul G. [Auteur]
Boutchakova, Maria [Auteur]
Siddiqui, Adnan H. [Auteur]
Lapergue, Bertrand [Auteur]
Dorn, Franziska [Auteur]
Cognard, Christophe [Auteur]
Killer, Monika [Auteur]
Mangiafico, Salvatore [Auteur]
Ribo, Marc [Auteur]
Psychogios, Marios N. [Auteur]
Spiotta, Alejandro M. [Auteur]
Labeyrie, Marc Antoine [Auteur]
Biondi, Alessandra [Auteur]
Mazighi, Mikael [Auteur]
Richard, Sébastien [Auteur]
Anxionnat, Rene [Auteur]
Bracard, Serge [Auteur]
Gory, Benjamin [Auteur]
Département de neuroradiologie diagnostique et thérapeutique [CHRU Nancy]

Journal title :

JACC: Cardiovascular Interventions

Abbreviated title :

JACC-Cardiovasc. Interv.

Volume number :

11

Pages :

1290-1299

Publisher :

Elsevier

Publication date :

2018-07-09

ISSN :

1936-8798

English keyword(s) :

carotid stenting
thrombectomy
recanalization
acute stroke

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

The aim of this study was to identify the optimal endovascular approach in patients with acute stroke with tandem lesions. At present, there is no consensus about the ideal technical strategy for the endovascular treatment ...
Show more >The aim of this study was to identify the optimal endovascular approach in patients with acute stroke with tandem lesions. At present, there is no consensus about the ideal technical strategy for the endovascular treatment of patients with acute ischemic stroke with tandem lesions of the extracranial internal carotid artery (ICA) and intracranial cerebral arteries. This was an international, multicenter registry with a total of 482 patients with acute ischemic stroke and tandem lesions. Patients were treated by intracranial thrombectomy as well as 1 of the following 4 strategies: 1) acute carotid artery stenting of the extracranial ICA with antithrombotic agents; 2) acute carotid artery stenting of the extracranial ICA without antithrombotic agents; 3) balloon angioplasty of the extracranial ICA; and 4) intracranial thrombectomy alone. The main outcome endpoints of the study were the degree of recanalization and the 90-day clinical outcome. The safety endpoints were symptomatic intracerebral hemorrhage and all causes of mortality at 90 days. Using univariate analysis, the rates of successful reperfusion (modified Thrombolysis in Cerebral Infarction grades 2B and 3) and favorable clinical outcome after 90 days were significantly higher after acute carotid stenting with antithrombotic therapy and thrombectomy compared with the group with thrombectomy alone. After adjusting for confounding variables, acute stenting with antithrombotic therapy was independently associated with successful recanalization (odds ratio: 2.4; 95% confidence interval: 1.25 to 4.59; p = 0.008). The rates of symptomatic intracerebral hemorrhage and 90-day mortality were comparable among all 4 treatment groups. Acute stenting of the extracranial ICA with antithrombotic therapy in combination with intracranial thrombectomy is associated with higher recanalization rates in treatment of patients with acute stroke with tandem lesions.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
Université de Lille

Collections :

• METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694

Submission date :

2019-12-09T18:18:43Z
2024-03-22T07:30:05Z