Title :

Arterial stiffness evaluated by pulse wave velocity is not predictive of the improvement in hypertension after adrenal surgery for primary aldosteronism: a multicentre study from the french european society of hypertension excellence centres

Author(s) :

Bouhanick, Béatrice [Auteur]
Amar, Jacques [Auteur]
Amar, Laurence [Auteur]
Gosse, Philippe [Auteur]
Girerd, Xavier [Auteur]
Reznik, Yves [Auteur]
Mounier Vehier, Claire [Auteur]
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Baguet, Jean-Philippe [Auteur]
Boutouyrie, Pierre [Auteur]
Lepage, Benoit [Auteur]
Lantelme, Pierre [Auteur]
Chamontin, Bernard [Auteur]

Journal title :

Archives of cardiovascular diseases

Abbreviated title :

Arch Cardiovasc Dis

Publication date :

2018-03-16

ISSN :

1875-2128

English keyword(s) :

Pulse wave velocity
Primary aldosteronism

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

BACKGROUND: Predictive factors associated with normal blood pressure (BP) after unilateral adrenalectomy for primary aldosteronism (PA) are not clearly identified. OBJECTIVE: To evaluate the predictive value of arterial ...
Show more >BACKGROUND: Predictive factors associated with normal blood pressure (BP) after unilateral adrenalectomy for primary aldosteronism (PA) are not clearly identified. OBJECTIVE: To evaluate the predictive value of arterial stiffness before surgery on BP after surgery. METHODS: During 2009-2013, 96 patients with PA due to unilateral adrenal adenoma who underwent surgery were enrolled in a multicentre open-label, prospective study. Aortic pulse wave velocity (PWV) was assessed before surgery. Patients underwent ambulatory blood pressure monitoring (ABPM) before surgery and 6 and 12months after surgery. Twenty-four h SBP/DBP values were compared in subjects with PWV<vs. ≥10m/s. The primary outcome was 24-hour ABPM<130/80mmHg 6 months after adrenalectomy. RESULTS: BP and PWV were available for 82 patients (mean age 49±12years). Mean 24-hour systolic/diastolic BP (SBP/DBP) values decreased from 144±15/91±9 before surgery to 131±15/84±11mmHg 6months after surgery. At 6months, mean 24-hour SBP did not differ significantly between high versus low PWV groups (SBP-0.8mmHg, 95% confidence interval-6.9 to 5.2, P=0.79). A total of 42.3% of women versus 20.0% of men had 24-hour SBP/DBP<130/80mmHg at 6months (P=0.07) and 57.9% vs. 23.8% at 12months (P=0.03). Higher SBP/DBP was recorded for men versus women after 6months (P=0.01/0.001) and 1year (P=0.04/0.05). CONCLUSIONS: Preoperative arterial stiffness does not predict a beneficial effect of adrenalectomy on BP values.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
Université de Lille

Collections :

• METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694

Submission date :

2019-12-09T18:19:24Z