Irisin levels in lmna-associated partial ...
Type de document :
Article dans une revue scientifique: Article original
PMID :
URL permanente :
Titre :
Irisin levels in lmna-associated partial lipodystrophies
Auteur(s) :
Bensmaine, F. [Auteur]
Benomar, Kanza [Auteur]
Stephanie, Espiard [Auteur]
Service Endocrinologie, diabétologie, maladies métaboliques et nutrition [LILLE - Endocrino]
Vahe, C. [Auteur]
Le Mapihan, K. [Auteur]
Lion, Georges [Auteur]
Lemdani, Mohamed [Auteur]
221576|||Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS] (VALID)
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Chazard, Emmanuel [Auteur]
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Ernst, Olivier [Auteur]
489340|||Thérapies Laser Assistées par l'Image pour l'Oncologie - U 1189 [ONCO-THAI] (VALID)
Thérapies Lasers Assistées par l'Image pour l'Oncologie (ONCO-THAI) - U1189
Vigouroux, C. [Auteur]
Pigny, Pascal [Auteur]
Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer (JPArc) - U1172
Vantyghem, Marie-Christine [Auteur]
Recherche translationnelle sur le diabète (RTD) - U1190
Benomar, Kanza [Auteur]
Stephanie, Espiard [Auteur]
Service Endocrinologie, diabétologie, maladies métaboliques et nutrition [LILLE - Endocrino]
Vahe, C. [Auteur]
Le Mapihan, K. [Auteur]
Lion, Georges [Auteur]
Lemdani, Mohamed [Auteur]
221576|||Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS] (VALID)
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Chazard, Emmanuel [Auteur]
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Ernst, Olivier [Auteur]
489340|||Thérapies Laser Assistées par l'Image pour l'Oncologie - U 1189 [ONCO-THAI] (VALID)
Thérapies Lasers Assistées par l'Image pour l'Oncologie (ONCO-THAI) - U1189
Vigouroux, C. [Auteur]
Pigny, Pascal [Auteur]
Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer (JPArc) - U1172
Vantyghem, Marie-Christine [Auteur]
Recherche translationnelle sur le diabète (RTD) - U1190
Titre de la revue :
Diabetes & Metabolism
Nom court de la revue :
Diabetes Metab.
Numéro :
45
Pagination :
67-75
Éditeur :
Elsevier Masson
Date de publication :
2018-08-27
ISSN :
1262-3636
Mot(s)-clé(s) en anglais :
Lamin A
Irisin
Lean mass
Leptin
Fat mass
Lipodystrophy
Irisin
Lean mass
Leptin
Fat mass
Lipodystrophy
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
The adipo-myokine irisin regulates energy expenditure and fat metabolism. LMNA-associated familial partial lipodystrophy (FPLD2) comprises insulin resistance, muscle hypertrophy and lipoatrophy. The aim of this study was ...
Lire la suite >The adipo-myokine irisin regulates energy expenditure and fat metabolism. LMNA-associated familial partial lipodystrophy (FPLD2) comprises insulin resistance, muscle hypertrophy and lipoatrophy. The aim of this study was to investigate whether irisin could be a biomarker of FPLD2. This case control study included 19 FPLD2 subjects, 13 obese non-diabetic (OND) patients and 19 healthy controls (HC) of normal weight (median BMI: 26, 39 and 22 kg/m2 BMI and MRI intra-abdominal fat significantly differed among these three groups, whereas DXA total fat mass and leptin levels were higher in the OND group, but did not differ between HC and FPLD2. Lipodystrophy patients had higher intra-abdominal/total abdominal fat ratios than the other two groups. Irisin levels were higher in FPLD2 and OND patients than in HC (medians: 944, 934 and 804 ng/mL, respectively). However, irisin/leptin ratios and lean body mass percentages were strikingly higher, and lean mass indices lower, in FPLD2 and HC than in the OND (median irisin/leptin ratios: 137, 166 and 21, respectively). In the entire study group, irisin levels positively correlated with BMI, lean body mass and index, intra-abdominal/total abdominal fat ratio, triglyceride, cholesterol, insulin, glucose and HbA1c Circulating irisin is similarly increased in FPLD2 and OND patients, who are characterized by higher lean body mass regardless of their clearly different fat mass. However, irisin/leptin ratios, strikingly higher in FPLD2 than in OND patients, could help to make the diagnosis and prompt genetic testing in clinically atypical cases.Lire moins >
Lire la suite >The adipo-myokine irisin regulates energy expenditure and fat metabolism. LMNA-associated familial partial lipodystrophy (FPLD2) comprises insulin resistance, muscle hypertrophy and lipoatrophy. The aim of this study was to investigate whether irisin could be a biomarker of FPLD2. This case control study included 19 FPLD2 subjects, 13 obese non-diabetic (OND) patients and 19 healthy controls (HC) of normal weight (median BMI: 26, 39 and 22 kg/m2 BMI and MRI intra-abdominal fat significantly differed among these three groups, whereas DXA total fat mass and leptin levels were higher in the OND group, but did not differ between HC and FPLD2. Lipodystrophy patients had higher intra-abdominal/total abdominal fat ratios than the other two groups. Irisin levels were higher in FPLD2 and OND patients than in HC (medians: 944, 934 and 804 ng/mL, respectively). However, irisin/leptin ratios and lean body mass percentages were strikingly higher, and lean mass indices lower, in FPLD2 and HC than in the OND (median irisin/leptin ratios: 137, 166 and 21, respectively). In the entire study group, irisin levels positively correlated with BMI, lean body mass and index, intra-abdominal/total abdominal fat ratio, triglyceride, cholesterol, insulin, glucose and HbA1c Circulating irisin is similarly increased in FPLD2 and OND patients, who are characterized by higher lean body mass regardless of their clearly different fat mass. However, irisin/leptin ratios, strikingly higher in FPLD2 than in OND patients, could help to make the diagnosis and prompt genetic testing in clinically atypical cases.Lire moins >
Langue :
Anglais
Audience :
Internationale
Vulgarisation :
Non
Établissement(s) :
CHU Lille
Inserm
Université de Lille
Inserm
Université de Lille
Collections :
Date de dépôt :
2019-12-09T18:20:37Z
2021-06-25T08:32:41Z
2024-04-03T08:10:00Z
2021-06-25T08:32:41Z
2024-04-03T08:10:00Z
Annexes
- document
- Accès libre
- Source du fichier principal
- Accéder au document