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Long-term fatigue in survivors of non-hodgkin ...
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Document type :
Article dans une revue scientifique: Article original
DOI :
10.1002/cncr.32040
PMID :
30901086
Permalink :
http://hdl.handle.net/20.500.12210/17836
Title :
Long-term fatigue in survivors of non-hodgkin lymphoma: the lymphoma study association simonal cross-sectional study
Author(s) :
Mounier, Nicolas [Auteur]
Anthony, Sabine [Auteur]
Busson, Raphael [Auteur]
Thieblemont, Catherine [Auteur]
Ribrag, Vincent [Auteur]
Tilly, Herve [Auteur]
Haioun, Corinne [Auteur]
Casasnovas, Rene-Olivier [Auteur]
Morschhauser, Franck [Auteur] refId
Groupe de Recherche sur les formes Injectables et les Technologies Associées - ULR 7365 [GRITA]
Feugier, Pierre [Auteur]
Delarue, Richard [Auteur]
Ysebaert, Loic [Auteur]
Sebban, Catherine [Auteur]
Broussais-Guillaumot, Florence [Auteur]
Damaj, Gandhi [Auteur]
Nerich, Virginie [Auteur]
Jais, Jean-Philippe [Auteur]
Laborde, Lilian [Auteur]
Salles, Gilles [Auteur]
Henry-Amar, Michel [Auteur]
Journal title :
Cancer
Abbreviated title :
Cancer
Publication date :
2019-03-22
ISSN :
1097-0142
English keyword(s) :
risk factors
cross-sectional study
long-term fatigue
long-term survivors
non-Hodgkin lymphomas
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
BACKGROUND: Long-term survivors of non-Hodgkin lymphoma (NHL) must cope with treatment complications and late toxicities that affect their health-related quality of life. Little is known about the risk-to-benefit ratio of ...
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BACKGROUND: Long-term survivors of non-Hodgkin lymphoma (NHL) must cope with treatment complications and late toxicities that affect their health-related quality of life. Little is known about the risk-to-benefit ratio of new agents like rituximab. The impact of treatment regimens and health disorders on long-term fatigue levels was investigated in a cross-sectional study. METHODS: Two self-administered questionnaires, the 20-item Multidimensional Fatigue Inventory (MFI-20) and a Life Situation Questionnaire, were mailed in 2015 to NHL survivors enrolled onto 12 successive clinical studies (1993-2010) conducted by the Lymphoma Study Association. Private addresses were obtained for 3317 survivors, of whom 1671 (50%) returned the questionnaires. Severe fatigue was defined as MFI-20 scores ≥60 on dimension scales scored from 0 to 100. Linear regression models were used to assess factors that were linked to increased fatigue levels. RESULTS: The study population included 906 men and 765 women, and the median age was 64 years (age range, 24-95 years). Overall, 811 survivors had received cyclophosphamide, doxorubicin, vincristine, prednisone (CHOP)-like chemotherapy, 518 had received high-dose CHOP, and 342 had undergone upfront autologous stem cell transplantation; 829 survivors also had received rituximab. In total, 1100 survivors (66%) reported 1 or more late health disorders. Severe fatigue was reported by 602 survivors (37%). Increased fatigue levels were associated (P < .001) with increased age, obesity, and the presence of health disorders, but not with initial treatment or rituximab. CONCLUSIONS: The survey confirms that high proportions long-term NHL survivors have severe fatigue. The results suggest that initial treatment and the receipt of rituximab have no influence on the development of long-term fatigue.Show less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
CHU Lille
Université de Lille
Collections :
  • Groupe de Recherche sur les formes Injectables et les Technologies Associées (GRITA) - ULR 7365
Research team(s) :
Modélisation biopharmaceutique et pharmacocinétique
Submission date :
2019-12-16T14:06:44Z
Université de Lille

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