Titre :

New spe-lc-ms/ms method for the simultaneous determination in urine of 22 metabolites of dehp and alternative plasticizers from pvc medical devices

Auteur(s) :

Pinguet, Jeremy [Auteur]
Kerckhove, Nicolas [Auteur]
Eljezi, Teuta [Auteur]
Lambert, Celine [Auteur]
Moreau, Emmanuel [Auteur]
Bernard, Lise [Auteur]
Boeuf, Benoit [Auteur]
Décaudin, Bertrand [Auteur]
Groupe de Recherche sur les formes Injectables et les Technologies Associées - ULR 7365 [GRITA]
Genay, Stéphanie [Auteur]
Masse, Morgane [Auteur]
Groupe de Recherche sur les formes Injectables et les Technologies Associées - ULR 7365 [GRITA]
Storme, Laurent [Auteur]
Environnement périnatal et croissance - EA 4489 [EPS]
Environnement Périnatal et Santé - EA 4489
Sautou, Valerie [Auteur]
Richard, Damien [Auteur]

Titre de la revue :

Talanta

Nom court de la revue :

Talanta

Numéro :

198

Pagination :

377-389

Date de publication :

2019-06-01

ISSN :

1873-3573

Mot(s)-clé(s) en anglais :

Alternative plasticizers
Medical devices
SPE-LC-MS/MS
Human biomonitoring
Urinary metabolite

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

DiEthylHexylPhthalate (DEHP) can leach out of plasticized PVC medical devices (MD) and may enter into contact with patients. This phthalate is known for its reprotoxic and endocrine disrupting effects. Its use in medical ...
Lire la suite >DiEthylHexylPhthalate (DEHP) can leach out of plasticized PVC medical devices (MD) and may enter into contact with patients. This phthalate is known for its reprotoxic and endocrine disrupting effects. Its use in medical devices (MD) has been restricted and alternative plasticizers have been developed. Nevertheless, no published clinical studies exist concerning patient exposure to these alternative plasticizers during medical care. This is particularly worrisome when high-risk populations, such as newborns, are exposed to these new plasticizers in intensive care units. Our study aimed to develop a novel sensitive and selective method to simultaneously identify and quantify DEHP and 17 other plasticizer metabolites (free or glucuronide conjugates), which are specific biomarkers of DEHTP, TOTM, DINP, DINCH and DEHA exposure in human urine. This robust method uses turbulent-flow online extraction technology coupled to high performance liquid chromatography - tandem mass spectrometry. Special care was taken to address two major problems in plasticizer analysis: contamination and chromatographic separation of interfering analogue structures. The validation was assessed in synthetic urine and the linearity of response was demonstrated for all compounds (R2Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

CHU Lille
Université de Lille

Collections :

• Environnement Périnatal et Santé - ULR 4489
• Groupe de Recherche sur les formes Injectables et les Technologies Associées (GRITA) - ULR 7365

Équipe(s) de recherche :

Innovation/évaluation des dispositifs médicaux de perfusion

Date de dépôt :

2019-12-16T14:06:46Z