Title :

New spe-lc-ms/ms method for the simultaneous determination in urine of 22 metabolites of dehp and alternative plasticizers from pvc medical devices

Author(s) :

Pinguet, Jeremy [Auteur]
Kerckhove, Nicolas [Auteur]
Eljezi, Teuta [Auteur]
Lambert, Celine [Auteur]
Moreau, Emmanuel [Auteur]
Bernard, Lise [Auteur]
Boeuf, Benoit [Auteur]
Décaudin, Bertrand [Auteur]
Groupe de Recherche sur les formes Injectables et les Technologies Associées - ULR 7365 [GRITA]
Genay, Stéphanie [Auteur]
Masse, Morgane [Auteur]
Groupe de Recherche sur les formes Injectables et les Technologies Associées - ULR 7365 [GRITA]
Storme, Laurent [Auteur]
Environnement Périnatal et Santé - EA 4489
Environnement périnatal et croissance - EA 4489 [EPS]
Sautou, Valerie [Auteur]
Richard, Damien [Auteur]

Journal title :

Talanta

Abbreviated title :

Talanta

Volume number :

198

Pages :

377-389

Publication date :

2019-06-01

ISSN :

1873-3573

English keyword(s) :

Alternative plasticizers
Medical devices
SPE-LC-MS/MS
Human biomonitoring
Urinary metabolite

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

DiEthylHexylPhthalate (DEHP) can leach out of plasticized PVC medical devices (MD) and may enter into contact with patients. This phthalate is known for its reprotoxic and endocrine disrupting effects. Its use in medical ...
Show more >DiEthylHexylPhthalate (DEHP) can leach out of plasticized PVC medical devices (MD) and may enter into contact with patients. This phthalate is known for its reprotoxic and endocrine disrupting effects. Its use in medical devices (MD) has been restricted and alternative plasticizers have been developed. Nevertheless, no published clinical studies exist concerning patient exposure to these alternative plasticizers during medical care. This is particularly worrisome when high-risk populations, such as newborns, are exposed to these new plasticizers in intensive care units. Our study aimed to develop a novel sensitive and selective method to simultaneously identify and quantify DEHP and 17 other plasticizer metabolites (free or glucuronide conjugates), which are specific biomarkers of DEHTP, TOTM, DINP, DINCH and DEHA exposure in human urine. This robust method uses turbulent-flow online extraction technology coupled to high performance liquid chromatography - tandem mass spectrometry. Special care was taken to address two major problems in plasticizer analysis: contamination and chromatographic separation of interfering analogue structures. The validation was assessed in synthetic urine and the linearity of response was demonstrated for all compounds (R2Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
Université de Lille

Collections :

• Environnement Périnatal et Santé - ULR 4489
• Groupe de Recherche sur les formes Injectables et les Technologies Associées (GRITA) - ULR 7365

Research team(s) :

Innovation/évaluation des dispositifs médicaux de perfusion

Submission date :

2019-12-16T14:06:46Z