Title :

Predictors of lung function test severity and outcome in systemic sclerosis-associated interstitial lung disease

Author(s) :

Le Gouellec, No [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Duhamel, Alain [Auteur]
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Perez, Thierry [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Hachulla, Anne-Lise [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Sobanski, Vincent [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Lille Inflammation Research International Center (LIRIC) - U995
Faivre, Jean-Baptiste [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Morell-Dubois, Sandrine [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Lambert, Marc [Auteur]
Lille Inflammation Research International Center (LIRIC) - U995
Lille Inflammation Research International Center - U 995 [LIRIC]
Hatron, Pierre-Yves [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Hachulla, Eric [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Behal, Helene [Auteur]
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Matran, Regis [Auteur]
IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483
Impact de l'environnement chimique sur la santé humaine - ULR 4483 [IMPECS]
Launay, David [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Remy, Martine [Auteur]
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694

Journal title :

PLoS One

Abbreviated title :

PLoS One

Volume number :

12

Publication date :

2017-08-01

ISSN :

1932-6203

English keyword(s) :

Mesh:Adult
Mesh:Adolescent
Mesh:Aged
Mesh:Aged
Mesh:80 and over
Mesh:Carbon Monoxide/chemistry
Mesh:Cyclophosphamide/therapeutic use
Mesh:Diffusion
Mesh:Echocardiography
Mesh:Female
Mesh:Fingers/pathology
Mesh:Follow-Up Studies
Mesh:Humans
Mesh:Hypertension
Mesh:Pulmonary/physiopathology
Mesh:Linear Models
Mesh:Lung/physiopathology
Mesh:Lung Diseases
Mesh:Interstitial/complications*
Mesh:Lung Diseases
Mesh:Interstitial/physiopathology
Mesh:Male
Mesh:Methotrexate/therapeutic use
Mesh:Middle Aged
Mesh:Mycophenolic Acid/therapeutic use
Mesh:Pulmonary Diffusing Capacity*
Mesh:Respiratory Function Tests*
Mesh:Scleroderma
Mesh:Systemic/complications*
Mesh:Scleroderma
Mesh:Systemic/physiopathology
Mesh:Ulcer/pathology
Mesh:Young Adult

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Systemic sclerosis-related interstitial lung disease (SSc-ILD) is the leading cause of death in SSc. In this study, we aimed to describe the baseline severity and evolution of forced vital capacity (FVC) and diffusing ...
Show more >Systemic sclerosis-related interstitial lung disease (SSc-ILD) is the leading cause of death in SSc. In this study, we aimed to describe the baseline severity and evolution of forced vital capacity (FVC) and diffusing capacity for carbon monoxide (DLCO) in patients with SSc-ILD and to assess the baseline clinical, biological and high-resolution CT scan (HRCT) predictors of this evolution. Baseline and serial FVC and DLCO were collected in 75 SSc-ILD patients followed during 6.4±4.2 years (n = 557 individual data). FVC and DLCO evolution was modelled using a linear mixed model with random effect. During follow-up, FVC was stable while DLCO significantly decreased (-1.5±0.3%/year (p<0.0001). Baseline NYHA functional class III/IV, extensive SSc-ILD on HRCT and DLCO<80% were associated with a lower baseline FVC. Absence of digital ulcers extensive SSc-ILD, and FVC<80% and were associated with a lower baseline DLCO. Presence or history of digital ulcers and presence of pulmonary hypertension at baseline or during follow-up were associated with a faster decline of DLCO overtime. Neither age, gender, subtype of SSc nor specificity of autoantibodies were associated with baseline severity or outcome of lung function tests. In this SSc-ILD population, FVC was therefore stable while DLCO significantly declined over time. ILD extension was associated with baseline FVC and DLCO but not with their evolution. Presence or history of digital ulcers and pulmonary hypertension were predictors of a faster decline of DLCO over time.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
CNRS
Inserm
Institut Pasteur de Lille
Université de Lille

Collections :

• METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694

Submission date :

2020-02-11T09:07:26Z
2020-03-26T10:01:58Z