Diagnosis of primary antibody and complement ...
Type de document :
Article dans une revue scientifique: Article original
PMID :
URL permanente :
Titre :
Diagnosis of primary antibody and complement deficiencies in young adults after a first invasive bacterial infection
Auteur(s) :
Sanges, Sebastien [Auteur]
Lille Inflammation Research International Center (LIRIC) - U995
Lille Inflammation Research International Center - U 995 [LIRIC]
Wallet, Florent [Auteur]
Blondiaux, Nicolas [Auteur]
Theis, D. [Auteur]
Verin, I. [Auteur]
Vachee, Anne [Auteur]
Dessein, Rodrigue [Auteur]
Recherche translationnelle : relations hôte-pathogènes - EA 7366
Recherche translationelle relations hôte-pathogènes
Recherche translationelle relations hôte-pathogènes
Faure, Karine [Auteur]
Recherche translationnelle : relations hôte-pathogènes - EA 7366
Recherche translationelle relations hôte-pathogènes
Recherche translationelle relations hôte-pathogènes
Viget, N. [Auteur]
Senneville, Eric [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Leroy, Olivier [Auteur]
Maury, F. [Auteur]
Just, Nicolas [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Poissy, Julien [Auteur]
Lille Inflammation Research International Center (LIRIC) - U995
Lille Inflammation Research International Center - U 995 [LIRIC]
Mathieu, Daniel [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Prevotat, Anne [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Chenivesse, Cecile [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
SCHERPEREEL, Arnaud [Auteur]
Centre d'Infection et d'Immunité de Lille (CIIL) - U1019 - UMR 8204
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Smith, G. [Auteur]
Lopez, B. [Auteur]
Rosain, J. [Auteur]
Fremeaux-Bacchi, V. [Auteur]
Hachulla, Eric [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Hatron, Pierre-Yves [Auteur]
Bahuaud, M. [Auteur]
Batteux, Frédéric [Auteur]
Launay, David [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Labalette, Myriam [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Lefevre, Guillaume [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
wallet [Auteur]
Lille Inflammation Research International Center (LIRIC) - U995
Lille Inflammation Research International Center - U 995 [LIRIC]
Wallet, Florent [Auteur]
Blondiaux, Nicolas [Auteur]
Theis, D. [Auteur]
Verin, I. [Auteur]
Vachee, Anne [Auteur]
Dessein, Rodrigue [Auteur]
Recherche translationnelle : relations hôte-pathogènes - EA 7366
Recherche translationelle relations hôte-pathogènes
Recherche translationelle relations hôte-pathogènes
Faure, Karine [Auteur]
Recherche translationnelle : relations hôte-pathogènes - EA 7366
Recherche translationelle relations hôte-pathogènes
Recherche translationelle relations hôte-pathogènes
Viget, N. [Auteur]
Senneville, Eric [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Leroy, Olivier [Auteur]
Maury, F. [Auteur]
Just, Nicolas [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Poissy, Julien [Auteur]
Lille Inflammation Research International Center (LIRIC) - U995
Lille Inflammation Research International Center - U 995 [LIRIC]
Mathieu, Daniel [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Prevotat, Anne [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Chenivesse, Cecile [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
SCHERPEREEL, Arnaud [Auteur]
Centre d'Infection et d'Immunité de Lille (CIIL) - U1019 - UMR 8204
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Smith, G. [Auteur]
Lopez, B. [Auteur]
Rosain, J. [Auteur]
Fremeaux-Bacchi, V. [Auteur]
Hachulla, Eric [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Hatron, Pierre-Yves [Auteur]
Bahuaud, M. [Auteur]
Batteux, Frédéric [Auteur]
Launay, David [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Labalette, Myriam [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Lefevre, Guillaume [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
wallet [Auteur]
Titre de la revue :
Clinical microbiology and infection . the official publication of the European Society of Clinical Microbiology and Infectious Diseases
Nom court de la revue :
Clin. Microbiol. Infect.
Numéro :
23
Date de publication :
2017-08-01
ISSN :
1198-743X
Mot(s)-clé(s) en anglais :
Immunoglobulin deficiency
Haemophilus influenzae
Group A Streptococcus
Neisseria meningitidis
Primary immunodeficiency
Neisseria gonorrhoeae
Common variable immunodeficiency
Complement deficiency
Streptococcus pneumoniae
Haemophilus influenzae
Group A Streptococcus
Neisseria meningitidis
Primary immunodeficiency
Neisseria gonorrhoeae
Common variable immunodeficiency
Complement deficiency
Streptococcus pneumoniae
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
OBJECTIVE: Screening for primary immunodeficiencies (PIDs) in adults is recommended after two severe bacterial infections. We aimed to evaluate if screening should be performed after the first invasive infection in young ...
Lire la suite >OBJECTIVE: Screening for primary immunodeficiencies (PIDs) in adults is recommended after two severe bacterial infections. We aimed to evaluate if screening should be performed after the first invasive infection in young adults. METHODS: Eligible patients were retrospectively identified using hospital discharge and bacteriology databases in three centres during a 3-year period. Eighteen to 40-year-old patients were included if they had experienced an invasive infection with encapsulated bacteria commonly encountered in PIDs (Streptococcus pneumoniae (SP), Neisseria meningitidis (NM), Neisseria gonorrhoeae (NG), Haemophilus influenzae (HI), or group A Streptococcus (GAS)). They were excluded in case of general or local predisposing factors. Immunological explorations and PIDs diagnoses were retrieved from medical records. Serum complement and IgG/A/M testings were systematically proposed at the time of study to patients with previously incomplete PID screening. RESULTS: The study population comprised 38 patients. Thirty-six had experienced a first invasive episode and a PID was diagnosed in seven (19%): two cases of common variable immunodeficiency revealed by SP bacteraemia, one case of idiopathic primary hypogammaglobulinaemia, and two cases of complement (C6 and C7) deficiency revealed by NM meningitis, one case of IgG2/IgG4 subclasses deficiency revealed by GAS bacteraemia, and one case of specific polysaccharide antibody deficiency revealed by HI meningitis. Two patients had previously experienced an invasive infection before the study period: in both cases, a complement deficiency was diagnosed after a second NM meningitis and a second NG bacteraemia, respectively. CONCLUSIONS: PID screening should be considered after a first unexplained invasive encapsulated-bacterial infection in young adults.Lire moins >
Lire la suite >OBJECTIVE: Screening for primary immunodeficiencies (PIDs) in adults is recommended after two severe bacterial infections. We aimed to evaluate if screening should be performed after the first invasive infection in young adults. METHODS: Eligible patients were retrospectively identified using hospital discharge and bacteriology databases in three centres during a 3-year period. Eighteen to 40-year-old patients were included if they had experienced an invasive infection with encapsulated bacteria commonly encountered in PIDs (Streptococcus pneumoniae (SP), Neisseria meningitidis (NM), Neisseria gonorrhoeae (NG), Haemophilus influenzae (HI), or group A Streptococcus (GAS)). They were excluded in case of general or local predisposing factors. Immunological explorations and PIDs diagnoses were retrieved from medical records. Serum complement and IgG/A/M testings were systematically proposed at the time of study to patients with previously incomplete PID screening. RESULTS: The study population comprised 38 patients. Thirty-six had experienced a first invasive episode and a PID was diagnosed in seven (19%): two cases of common variable immunodeficiency revealed by SP bacteraemia, one case of idiopathic primary hypogammaglobulinaemia, and two cases of complement (C6 and C7) deficiency revealed by NM meningitis, one case of IgG2/IgG4 subclasses deficiency revealed by GAS bacteraemia, and one case of specific polysaccharide antibody deficiency revealed by HI meningitis. Two patients had previously experienced an invasive infection before the study period: in both cases, a complement deficiency was diagnosed after a second NM meningitis and a second NG bacteraemia, respectively. CONCLUSIONS: PID screening should be considered after a first unexplained invasive encapsulated-bacterial infection in young adults.Lire moins >
Langue :
Anglais
Audience :
Internationale
Vulgarisation :
Non
Établissement(s) :
CHU Lille
CNRS
Inserm
Institut Pasteur de Lille
Université de Lille
CNRS
Inserm
Institut Pasteur de Lille
Université de Lille
Collections :
Date de dépôt :
2020-02-11T09:07:30Z
2021-05-18T12:51:54Z
2021-05-18T12:51:54Z