Title :

Gangliosides: Structures, Biosynthesis, Analysis, and Roles in Cancer

Author(s) :

Groux, Sophie [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Unité de Glycobiologie Structurale et Fonctionnelle UMR 8576 [UGSF]
Guerardel, Yann [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Unité de Glycobiologie Structurale et Fonctionnelle UMR 8576 [UGSF]
Delannoy, Philippe [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Unité de Glycobiologie Structurale et Fonctionnelle UMR 8576 [UGSF]

Journal title :

Chembiochem. A European Journal of Chemical Biology

Abbreviated title :

Chembiochem

Volume number :

18

Pages :

1146-1154

Publication date :

2017

ISSN :

1439-7633

English keyword(s) :

Carbohydrate Sequence
Membrane Microdomains
Cell Proliferation
Signal Transduction
Glycosyltransferase
Humans
Antineoplastic Agents
gangliosides
Antibodies, Monoclonal
Sialyltransferase
Molecular Targeted Therapy
Cell Adhesion
Disease Progression
Neoplasms
Sialic Acid
Animals
Glycosphingolipids
immunotherapy
cancer
Carbohydrate Conformation
immunology

HAL domain(s) :

Chimie/Chimie théorique et/ou physique

English abstract : [en]

Gangliosides are acidic glycosphingolipids containing one or more sialic acid residues. They are essential compounds at the outer leaflet of the plasma membrane, where they interact with phospholipids, cholesterol, and ...
Show more >Gangliosides are acidic glycosphingolipids containing one or more sialic acid residues. They are essential compounds at the outer leaflet of the plasma membrane, where they interact with phospholipids, cholesterol, and transmembrane proteins, forming lipid rafts. They are involved in cell adhesion, proliferation, and recognition processes, as well as in the modulation of signal transduction pathways. These functions are mainly governed by the glycan moiety, and changes in the structures of gangliosides occur under pathological conditions, particularly in neuro-ectoderm-derived cancers. With the progress in mass spectrometry analysis of gangliosides, their role in cancer progression can be now investigated in more detail. In this review we summarize the current knowledge on the biosynthesis of gangliosides and their role in cancers, together with the recent development of cancer immunotherapy targeting gangliosides.Show less >

Language :

Anglais

Administrative institution(s) :

CNRS
Université de Lille

Collections :

• Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576

Research team(s) :

Régulation de la glycosylation terminale
Chemical Glycobiology

Submission date :

2020-02-12T15:11:06Z