Titre :

Gangliosides: Structures, Biosynthesis, Analysis, and Roles in Cancer

Auteur(s) :

Groux, Sophie [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Guerardel, Yann [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Delannoy, Philippe [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]

Titre de la revue :

Chembiochem. A European Journal of Chemical Biology

Nom court de la revue :

Chembiochem

Numéro :

18

Pagination :

1146-1154

Date de publication :

2017

ISSN :

1439-7633

Mot(s)-clé(s) en anglais :

Carbohydrate Sequence
Membrane Microdomains
Cell Proliferation
Signal Transduction
Glycosyltransferase
Humans
Antineoplastic Agents
gangliosides
Antibodies, Monoclonal
Sialyltransferase
Molecular Targeted Therapy
Cell Adhesion
Disease Progression
Neoplasms
Sialic Acid
Animals
Glycosphingolipids
immunotherapy
cancer
Carbohydrate Conformation
immunology

Discipline(s) HAL :

Chimie/Chimie théorique et/ou physique

Résumé en anglais : [en]

Gangliosides are acidic glycosphingolipids containing one or more sialic acid residues. They are essential compounds at the outer leaflet of the plasma membrane, where they interact with phospholipids, cholesterol, and ...
Lire la suite >Gangliosides are acidic glycosphingolipids containing one or more sialic acid residues. They are essential compounds at the outer leaflet of the plasma membrane, where they interact with phospholipids, cholesterol, and transmembrane proteins, forming lipid rafts. They are involved in cell adhesion, proliferation, and recognition processes, as well as in the modulation of signal transduction pathways. These functions are mainly governed by the glycan moiety, and changes in the structures of gangliosides occur under pathological conditions, particularly in neuro-ectoderm-derived cancers. With the progress in mass spectrometry analysis of gangliosides, their role in cancer progression can be now investigated in more detail. In this review we summarize the current knowledge on the biosynthesis of gangliosides and their role in cancers, together with the recent development of cancer immunotherapy targeting gangliosides.Lire moins >

Langue :

Anglais

Établissement(s) :

CNRS
Université de Lille

Collections :

• Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576

Équipe(s) de recherche :

Régulation de la glycosylation terminale
Chemical Glycobiology

Date de dépôt :

2020-02-12T15:11:06Z