Preliminary evidence for a serum disaccharide ...
Type de document :
Article dans une revue scientifique
PMID :
URL permanente :
Titre :
Preliminary evidence for a serum disaccharide signature of invasive Candida albicans infection detected by MALDI Mass Spectrometry
Auteur(s) :
Sendid, Boualem [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Lille Inflammation Research International Center (LIRIC) - U995
Poissy, Julien [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Lille Inflammation Research International Center (LIRIC) - U995
Francois, Nadine [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Mery, Alexandre [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Courtecuisse, S. [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Krzewinski, Frederic [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Jawhara, Samir [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Guerardel, Yann [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Poulain, Daniel [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Lille Inflammation Research International Center - U 995 [LIRIC]
Lille Inflammation Research International Center (LIRIC) - U995
Poissy, Julien [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Lille Inflammation Research International Center (LIRIC) - U995
Francois, Nadine [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Mery, Alexandre [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Courtecuisse, S. [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Krzewinski, Frederic [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Jawhara, Samir [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Guerardel, Yann [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Poulain, Daniel [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Titre de la revue :
Clinical Microbiology and Infection. The Official Publication of the European Society of Clinical Microbiology and Infectious Diseases
Nom court de la revue :
Clin. Microbiol. Infect.
Numéro :
21
Pagination :
88.e1-6
Date de publication :
2015-01
ISSN :
1469-0691
Mot(s)-clé(s) en anglais :
Candida albicans
diagnosis
disaccharide
invasive fungalinfections
mass spectrometry
matrix-assisted laser desorption/ionization time-offlight
diagnosis
disaccharide
invasive fungalinfections
mass spectrometry
matrix-assisted laser desorption/ionization time-offlight
Discipline(s) HAL :
Chimie/Chimie théorique et/ou physique
Résumé en anglais : [en]
The diagnosis of systemic Candida infections is a recognized challenge. We developed a mass spectrometry strategy to detect signals from Candida molecules in patients' sera. Pre-analytical procedures were designed to extract ...
Lire la suite >The diagnosis of systemic Candida infections is a recognized challenge. We developed a mass spectrometry strategy to detect signals from Candida molecules in patients' sera. Pre-analytical procedures were designed to extract oligosaccharides from serum. A peak m/z of at 365 was specifically revealed in sera from patients with candidaemia with regard to healthy controls. This biomarker was identified as a disaccharide, its presence did not correlate with mannanaemia or glucanaemia. Mouse models of Candida albicans colonization and infection showed that the signal was specifically associated with tissue invasion, suggesting that clinical evaluation of its usefulness in discriminating colonized and infected patients would be worthwhile.Lire moins >
Lire la suite >The diagnosis of systemic Candida infections is a recognized challenge. We developed a mass spectrometry strategy to detect signals from Candida molecules in patients' sera. Pre-analytical procedures were designed to extract oligosaccharides from serum. A peak m/z of at 365 was specifically revealed in sera from patients with candidaemia with regard to healthy controls. This biomarker was identified as a disaccharide, its presence did not correlate with mannanaemia or glucanaemia. Mouse models of Candida albicans colonization and infection showed that the signal was specifically associated with tissue invasion, suggesting that clinical evaluation of its usefulness in discriminating colonized and infected patients would be worthwhile.Lire moins >
Langue :
Anglais
Audience :
Non spécifiée
Projet Européen :
Établissement(s) :
CNRS
Université de Lille
Université de Lille
Collections :
Équipe(s) de recherche :
Chemical Glycobiology
Date de dépôt :
2020-02-12T15:11:09Z
2021-05-05T09:58:58Z
2021-05-26T12:33:02Z
2021-05-05T09:58:58Z
2021-05-26T12:33:02Z