Title :

Preliminary evidence for a serum disaccharide signature of invasive Candida albicans infection detected by MALDI Mass Spectrometry

Author(s) :

Sendid, Boualem [Auteur]
Lille Inflammation Research International Center (LIRIC) - U995
Lille Inflammation Research International Center - U 995 [LIRIC]
Poissy, Julien [Auteur]
Lille Inflammation Research International Center (LIRIC) - U995
Lille Inflammation Research International Center - U 995 [LIRIC]
Francois, Nadine [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Mery, Alexandre [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle UMR 8576 [UGSF]
Courtecuisse, S. [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Krzewinski, Frederic [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Unité de Glycobiologie Structurale et Fonctionnelle UMR 8576 [UGSF]
Jawhara, Samir [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Guerardel, Yann [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Unité de Glycobiologie Structurale et Fonctionnelle UMR 8576 [UGSF]
Poulain, Daniel [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]

Journal title :

Clinical Microbiology and Infection. The Official Publication of the European Society of Clinical Microbiology and Infectious Diseases

Abbreviated title :

Clin. Microbiol. Infect.

Volume number :

21

Pages :

88.e1-6

Publication date :

2015-01

ISSN :

1469-0691

English keyword(s) :

Candida albicans
diagnosis
disaccharide
invasive fungalinfections
mass spectrometry
matrix-assisted laser desorption/ionization time-offlight

HAL domain(s) :

Chimie/Chimie théorique et/ou physique

English abstract : [en]

The diagnosis of systemic Candida infections is a recognized challenge. We developed a mass spectrometry strategy to detect signals from Candida molecules in patients' sera. Pre-analytical procedures were designed to extract ...
Show more >The diagnosis of systemic Candida infections is a recognized challenge. We developed a mass spectrometry strategy to detect signals from Candida molecules in patients' sera. Pre-analytical procedures were designed to extract oligosaccharides from serum. A peak m/z of at 365 was specifically revealed in sera from patients with candidaemia with regard to healthy controls. This biomarker was identified as a disaccharide, its presence did not correlate with mannanaemia or glucanaemia. Mouse models of Candida albicans colonization and infection showed that the signal was specifically associated with tissue invasion, suggesting that clinical evaluation of its usefulness in discriminating colonized and infected patients would be worthwhile.Show less >

Language :

Anglais

Audience :

Non spécifiée

European Project :

Fungi in the setting of inflammation, allergy and autoimmune diseases:Translating basic science into clinical practices

Administrative institution(s) :

CNRS
Université de Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
• Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576

Research team(s) :

Chemical Glycobiology

Submission date :

2020-02-12T15:11:09Z
2021-05-05T09:58:58Z
2021-05-26T12:33:02Z