RINspector: a Cytoscape app for centrality ...
Type de document :
Article dans une revue scientifique
PMID :
URL permanente :
Titre :
RINspector: a Cytoscape app for centrality analyses and DynaMine flexibility prediction
Auteur(s) :
Brysbaert, Guillaume [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle UMR 8576 [UGSF]
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Lorgouilloux, Kevin [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Vranken, Wim [Auteur]
Interuniversity Institute of Bioinformatics in Brussels [IB2]
Structural Biology Brussels [SBB]
Lensink, Marc [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle UMR 8576 [UGSF]
Unité de Glycobiologie Structurale et Fonctionnelle UMR 8576 [UGSF]
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Lorgouilloux, Kevin [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Vranken, Wim [Auteur]
Interuniversity Institute of Bioinformatics in Brussels [IB2]
Structural Biology Brussels [SBB]
Lensink, Marc [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle UMR 8576 [UGSF]
Titre de la revue :
Bioinformatics (Oxford, England)
Nom court de la revue :
Bioinformatics
Date de publication :
2017-09-22
ISSN :
1367-4811
Discipline(s) HAL :
Chimie/Chimie théorique et/ou physique
Résumé en anglais : [en]
Motivation: Protein function is directly related to amino acid residue composition and the dynamics of these residues. Centrality analyses based on residue interaction networks permit to identify key residues in a protein ...
Lire la suite >Motivation: Protein function is directly related to amino acid residue composition and the dynamics of these residues. Centrality analyses based on residue interaction networks permit to identify key residues in a protein that are important for its fold or function. Such central residues and their environment constitute suitable targets for mutagenesis experiments. Predicted flexibility and changes in flexibility upon mutation provide valuable additional information for the design of such experiments. Results: We combined centrality analyses with DynaMine flexibility predictions in a Cytoscape app called RINspector. The app performs centrality analyses and directly visualizes the results on a graph of predicted residue flexibility. In addition, the effect of mutations on local flexibility can be calculated. Availability: The app is publicly available in the Cytoscape app store. Contact: guillaume.brysbaert@univ-lille1.fr. Supplementary information: Supplementary data are available at Bioinformatics online.Lire moins >
Lire la suite >Motivation: Protein function is directly related to amino acid residue composition and the dynamics of these residues. Centrality analyses based on residue interaction networks permit to identify key residues in a protein that are important for its fold or function. Such central residues and their environment constitute suitable targets for mutagenesis experiments. Predicted flexibility and changes in flexibility upon mutation provide valuable additional information for the design of such experiments. Results: We combined centrality analyses with DynaMine flexibility predictions in a Cytoscape app called RINspector. The app performs centrality analyses and directly visualizes the results on a graph of predicted residue flexibility. In addition, the effect of mutations on local flexibility can be calculated. Availability: The app is publicly available in the Cytoscape app store. Contact: guillaume.brysbaert@univ-lille1.fr. Supplementary information: Supplementary data are available at Bioinformatics online.Lire moins >
Langue :
Anglais
Audience :
Non spécifiée
Établissement(s) :
CNRS
Université de Lille
Université de Lille
Équipe(s) de recherche :
Computational Molecular Systems Biology
Date de dépôt :
2020-02-12T15:11:23Z
2021-04-21T08:04:53Z
2021-04-21T08:04:53Z
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