RINspector: a Cytoscape app for centrality ...
Document type :
Article dans une revue scientifique
PMID :
Permalink :
Title :
RINspector: a Cytoscape app for centrality analyses and DynaMine flexibility prediction
Author(s) :
Brysbaert, Guillaume [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle UMR 8576 [UGSF]
Lorgouilloux, Kevin [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Vranken, Wim [Auteur]
Structural Biology Brussels [SBB]
Interuniversity Institute of Bioinformatics in Brussels [IB2]
Lensink, Marc [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle UMR 8576 [UGSF]
Unité de Glycobiologie Structurale et Fonctionnelle UMR 8576 [UGSF]
Lorgouilloux, Kevin [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Vranken, Wim [Auteur]
Structural Biology Brussels [SBB]
Interuniversity Institute of Bioinformatics in Brussels [IB2]
Lensink, Marc [Auteur]

Unité de Glycobiologie Structurale et Fonctionnelle UMR 8576 [UGSF]
Journal title :
Bioinformatics (Oxford, England)
Abbreviated title :
Bioinformatics
Publication date :
2017-09-22
ISSN :
1367-4811
HAL domain(s) :
Chimie/Chimie théorique et/ou physique
English abstract : [en]
Motivation: Protein function is directly related to amino acid residue composition and the dynamics of these residues. Centrality analyses based on residue interaction networks permit to identify key residues in a protein ...
Show more >Motivation: Protein function is directly related to amino acid residue composition and the dynamics of these residues. Centrality analyses based on residue interaction networks permit to identify key residues in a protein that are important for its fold or function. Such central residues and their environment constitute suitable targets for mutagenesis experiments. Predicted flexibility and changes in flexibility upon mutation provide valuable additional information for the design of such experiments. Results: We combined centrality analyses with DynaMine flexibility predictions in a Cytoscape app called RINspector. The app performs centrality analyses and directly visualizes the results on a graph of predicted residue flexibility. In addition, the effect of mutations on local flexibility can be calculated. Availability: The app is publicly available in the Cytoscape app store. Contact: guillaume.brysbaert@univ-lille1.fr. Supplementary information: Supplementary data are available at Bioinformatics online.Show less >
Show more >Motivation: Protein function is directly related to amino acid residue composition and the dynamics of these residues. Centrality analyses based on residue interaction networks permit to identify key residues in a protein that are important for its fold or function. Such central residues and their environment constitute suitable targets for mutagenesis experiments. Predicted flexibility and changes in flexibility upon mutation provide valuable additional information for the design of such experiments. Results: We combined centrality analyses with DynaMine flexibility predictions in a Cytoscape app called RINspector. The app performs centrality analyses and directly visualizes the results on a graph of predicted residue flexibility. In addition, the effect of mutations on local flexibility can be calculated. Availability: The app is publicly available in the Cytoscape app store. Contact: guillaume.brysbaert@univ-lille1.fr. Supplementary information: Supplementary data are available at Bioinformatics online.Show less >
Language :
Anglais
Audience :
Non spécifiée
Administrative institution(s) :
CNRS
Université de Lille
Université de Lille
Research team(s) :
Computational Molecular Systems Biology
Submission date :
2020-02-12T15:11:23Z
2021-04-21T08:04:53Z
2021-04-21T08:04:53Z
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