Title :

Activation of presynaptic oxytocin receptors enhances glutamate release in the ventral hippocampus of prenatally restraint stressed rats

Author(s) :

Mairesse, Jérôme [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Gatta, Eleonora [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Reynaert, Marie-Line [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Marrocco, Jordan [Auteur]
Rockefeller University [New York]
MORLEY-FLETCHER, Sara [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Soichot, Marion [Auteur]
Faculté de Médecine Henri Warembourg - Université de Lille
Deruyter, Lucie [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Van Camp, Gilles [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Bouwalerh, Hammou [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Fagioli, Francesca [Auteur]
Azienda Sanitaria Locale [ROMA] [ASL]
Pittaluga, Anna [Auteur]
Università degli studi di Genova = University of Genoa [UniGe]
Allorge, Delphine [Auteur]
Faculté de Médecine Henri Warembourg - Université de Lille
Nicoletti, Ferdinando [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Istituto Neurologico Mediterraneo [NEUROMED I.R.C.C.S.]
Maccari, Stefania [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576

Journal title :

Psychoneuroendocrinology

Volume number :

62

Pages :

36-46

Publisher :

Elsevier

Publication date :

2015-12

ISSN :

0306-4530

English keyword(s) :

Perinatal stress
Carbetocin
Anxiety
Social behavior
Glutamate
Ventral hippocampus

HAL domain(s) :

Chimie/Chimie théorique et/ou physique

English abstract : [en]

Oxytocin receptors are known to modulate synaptic transmission and network activity in the hippocampus, but their precise function has been only partially elucidated. Here, we have found that activation of presynaptic ...
Show more >Oxytocin receptors are known to modulate synaptic transmission and network activity in the hippocampus, but their precise function has been only partially elucidated. Here, we have found that activation of presynaptic oxytocin receptor with the potent agonist, carbetocin, enhanced depolarization-evoked glutamate release in the ventral hippocampus with no effect on GABA release. This evidence paved the way for examining the effect of carbetocin treatment in “prenatally restraint stressed” (PRS) rats, i.e., the offspring of dams exposed to repeated episodes of restraint stress during pregnancy. Adult PRS rats exhibit an anxious/depressive-like phenotype associated with an abnormal glucocorticoid feedback regulation of the hypothalamus-pituitary-adrenal (HPA) axis, and, remarkably, with a reduced depolarization-evoked glutamate release in the ventral hippocampus. Chronic systemic treatment with carbetocin (1 mg/kg, i.p., once a day for 2–3 weeks) in PRS rats corrected the defect in glutamate release, anxiety- and depressive-like behavior, and abnormalities in social behavior, in the HPA response to stress, and in the expression of stress-related genes in the hippocampus and amygdala. Of note, carbetocin treatment had no effect on these behavioral and neuroendocrine parameters in prenatally unstressed (control) rats, with the exception of a reduced expression of the oxytocin receptor gene in the amygdala. These findings disclose a novel function of oxytocin receptors in the hippocampus, and encourage the use of oxytocin receptor agonists in the treatment of stress-related psychiatric disorders in adult life.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
CNRS
Université de Lille
Institut Pasteur de Lille

Collections :

• IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483
• Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576

Research team(s) :

Glycostress

Submission date :

2020-02-12T15:12:19Z
2021-05-31T06:51:09Z
2024-01-31T13:39:26Z