Title :

Functional partnership between mGlu3 and mGlu5 metabotropic glutamate receptors in the central nervous system

Author(s) :

Di Menna, Luisa [Auteur]
Istituto Neurologico Mediterraneo [NEUROMED I.R.C.C.S.]
Joffe, Max E. [Auteur]
Vanderbilt University Medical Center [Nashville]
Iacovelli, Luisa [Auteur]
Department of Psychology [University of Roma "La Sapienza"]
Orlando, Rosamaria [Auteur]
Department of Psychology [University of Roma "La Sapienza"]
Lindsley, Craig W. [Auteur]
Vanderbilt University [Nashville]
Mairesse, Jérôme [Auteur]
Université Sorbonne Paris Cité [USPC]
Gressèns, Pierre [Auteur]
Université Paris Cité [UPCité]
Cannella, Milena [Auteur]
Istituto Neurologico Mediterraneo [NEUROMED I.R.C.C.S.]
Caraci, Filippo [Auteur]
Università degli studi di Catania = University of Catania [Unict]
Copani, Agata [Auteur]
Università degli studi di Catania = University of Catania [Unict]
Bruno, Valeria [Auteur]
Istituto Neurologico Mediterraneo [NEUROMED I.R.C.C.S.]
Battaglia, Giuseppe [Auteur]
Istituto Neurologico Mediterraneo [NEUROMED I.R.C.C.S.]
Conn, P. Jeffrey [Auteur]
Vanderbilt University Medical Center [Nashville]
Nicoletti, Ferdinando [Auteur]
Istituto Neurologico Mediterraneo [NEUROMED I.R.C.C.S.]

Journal title :

Neuropharmacology

Volume number :

128

Pages :

301-313

Publication date :

2018-01

ISSN :

00283908

English keyword(s) :

G-protein βγ subunits
Long-term depression
Metabotropic glutamate receptors
Neurodevelopment
Neuronal death
Polyphosphoinositide hydrolysis
Receptor-receptor cross-talk
Synaptic plasticity

HAL domain(s) :

Chimie/Chimie théorique et/ou physique

English abstract : [en]

mGlu5 receptors are involved in mechanisms of activity-dependent synaptic plasticity, and are targeted by drugs developed for the treatment of CNS disorders. We report that mGlu3 receptors, which are traditionally linked ...
Show more >mGlu5 receptors are involved in mechanisms of activity-dependent synaptic plasticity, and are targeted by drugs developed for the treatment of CNS disorders. We report that mGlu3 receptors, which are traditionally linked to the control of neurotransmitter release, support mGlu5 receptor signaling in neurons and largely contribute to the robust mGlu5 receptor-mediated polyphosphoinositide hydrolysis in the early postnatal life. In cortical pyramidal neurons, mGlu3 receptor activation potentiated mGlu5 receptor-mediated somatic Ca2+ mobilization, and mGlu3 receptor-mediated long-term depression in the prefrontal cortex required the endogenous activation of mGlu5 receptors. The interaction between mGlu3 and mGlu5 receptors was also relevant to mechanisms of neuronal toxicity, with mGlu3 receptors shaping the influence of mGlu5 receptors on excitotoxic neuronal death. These findings shed new light into the complex role played by mGlu receptors in physiology and pathology, and suggest reconsideration of some of the current dogmas in the mGlu receptor field.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CNRS
Université de Lille

Collections :

• Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576

Research team(s) :

Glycostress

Submission date :

2020-02-12T15:12:21Z
2024-02-23T09:31:25Z