First characterization of SmOPG1, a novel ...
Type de document :
Article dans une revue scientifique
URL permanente :
Titre :
First characterization of SmOPG1, a novel protein involved in gonad-associated processes in Schistosoma mansoni
Auteur(s) :
Hahnel, Steffen [Auteur]
Justus-Liebig-Universität Gießen = Justus Liebig University [JLU]
Parker-Manuel, Richard [Auteur]
Justus-Liebig-Universität Gießen = Justus Liebig University [JLU]
Dissous, Colette [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Cailliau, Katia [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Grevelding, Christoph G. [Auteur]
Justus-Liebig-Universität Gießen = Justus Liebig University [JLU]
Justus-Liebig-Universität Gießen = Justus Liebig University [JLU]
Parker-Manuel, Richard [Auteur]
Justus-Liebig-Universität Gießen = Justus Liebig University [JLU]
Dissous, Colette [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Cailliau, Katia [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Grevelding, Christoph G. [Auteur]
Justus-Liebig-Universität Gießen = Justus Liebig University [JLU]
Titre de la revue :
Molecular and Biochemical Parasitology
Numéro :
213
Pagination :
22-25
Date de publication :
2017-04
ISSN :
0166-6851
Mot(s)-clé(s) en anglais :
Schistosoma mansoni
Platyhelminth reproduction
Hypothetical protein
Mucin-like protein
Signaling
Gonad development
Platyhelminth reproduction
Hypothetical protein
Mucin-like protein
Signaling
Gonad development
Discipline(s) HAL :
Chimie/Chimie théorique et/ou physique
Sciences du Vivant [q-bio]/Biologie cellulaire
Sciences du Vivant [q-bio]/Biologie cellulaire
Résumé en anglais : [en]
In the context of investigating the exceptional reproductive biology of schistosomes, several studies have focused on the identification and characterization of involved molecules. Among these are cellular tyrosine kinases ...
Lire la suite >In the context of investigating the exceptional reproductive biology of schistosomes, several studies have focused on the identification and characterization of involved molecules. Among these are cellular tyrosine kinases (CTKs) which control differentiation processes in the female gonads. On the way to unravel CTK-mediated signaling processes in more detail, several upstream- and downstream partners of these CTKs were identified. In this context we present here first data characterizing the novel orphan gene Sm opg1. Annotated as hypothetical protein, SmOPG1 was identified as an interaction partner of the CTK SmTK6 by yeast two-hybrid library screening. Y2/3H interaction studies showed that SmTK6 binds with its SH2 domain to a specific binding motif within the C-terminus of SmOPG1. Additionally, in situ-hybridization and organ-specific RT-PCR analyses demonstrated the co-localization of SmOPG1 and SmTK6 transcripts in the gonads of adult S. mansoni. Finally, SmOPG1 knock-down provided first hints for a function in the ovary.Lire moins >
Lire la suite >In the context of investigating the exceptional reproductive biology of schistosomes, several studies have focused on the identification and characterization of involved molecules. Among these are cellular tyrosine kinases (CTKs) which control differentiation processes in the female gonads. On the way to unravel CTK-mediated signaling processes in more detail, several upstream- and downstream partners of these CTKs were identified. In this context we present here first data characterizing the novel orphan gene Sm opg1. Annotated as hypothetical protein, SmOPG1 was identified as an interaction partner of the CTK SmTK6 by yeast two-hybrid library screening. Y2/3H interaction studies showed that SmTK6 binds with its SH2 domain to a specific binding motif within the C-terminus of SmOPG1. Additionally, in situ-hybridization and organ-specific RT-PCR analyses demonstrated the co-localization of SmOPG1 and SmTK6 transcripts in the gonads of adult S. mansoni. Finally, SmOPG1 knock-down provided first hints for a function in the ovary.Lire moins >
Langue :
Anglais
Audience :
Non spécifiée
Établissement(s) :
CNRS
Université de Lille
Université de Lille
Collections :
Équipe(s) de recherche :
Régulation des signaux de division
Date de dépôt :
2020-02-12T15:12:36Z
2021-03-19T14:13:36Z
2021-03-19T14:16:13Z
2021-03-19T14:13:36Z
2021-03-19T14:16:13Z