How do they stick together? Bacterial ...
Type de document :
Article dans une revue scientifique
DOI :
URL permanente :
Titre :
How do they stick together? Bacterial adhesins implicated in the binding of bacteria to the human gastrointestinal mucins
Auteur(s) :
Ringot-Destrez, Bélinda [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Kalach, Nicolas [Auteur]
Groupement des Hôpitaux de l'Institut Catholique de Lille [GHICL]
Mihalache, Adriana [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Gosset, Pierre [Auteur]
Groupement des Hôpitaux de l'Institut Catholique de Lille [GHICL]
Michalski, Jean-Claude [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle UMR 8576 [UGSF]
Leonard, Renaud [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle UMR 8576 [UGSF]
Masselot, Catherine [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle UMR 8576 [UGSF]
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Kalach, Nicolas [Auteur]
Groupement des Hôpitaux de l'Institut Catholique de Lille [GHICL]
Mihalache, Adriana [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Gosset, Pierre [Auteur]
Groupement des Hôpitaux de l'Institut Catholique de Lille [GHICL]
Michalski, Jean-Claude [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle UMR 8576 [UGSF]
Leonard, Renaud [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle UMR 8576 [UGSF]
Masselot, Catherine [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle UMR 8576 [UGSF]
Titre de la revue :
Biochemical Society Transactions
Numéro :
45
Pagination :
389-399
Date de publication :
2017-04-15
Mot(s)-clé(s) en anglais :
microbiota
Gastrointestinal Tract
Humans
Homeostasis
Bacterial Physiological Phenomena
gastrointestinal mucins
Glycosylation
Adhesins, Bacterial
Bacterial Adhesion
pathogens
Mucins
Protein Binding
Adhesin
Membrane Glycoproteins
Gastrointestinal Tract
Humans
Homeostasis
Bacterial Physiological Phenomena
gastrointestinal mucins
Glycosylation
Adhesins, Bacterial
Bacterial Adhesion
pathogens
Mucins
Protein Binding
Adhesin
Membrane Glycoproteins
Discipline(s) HAL :
Chimie/Chimie théorique et/ou physique
Résumé en anglais : [en]
The gastrointestinal mucosal surface is the primary interface between internal host tissues and the vast microbiota. Mucins, key components of mucus, are high-molecular-weight glycoproteins characterized by the presence ...
Lire la suite >The gastrointestinal mucosal surface is the primary interface between internal host tissues and the vast microbiota. Mucins, key components of mucus, are high-molecular-weight glycoproteins characterized by the presence of many O-linked oligosaccharides to the core polypeptide. They play many biological functions, helping to maintain cellular homeostasis and to establish symbiotic relationships with complex microbiota. Mucin O-glycans exhibit a huge variety of peripheral sequences implicated in the binding of bacteria to the mucosal tissues, thereby playing a key role in the selection of specific species and in the tissue tropism displayed by commensal and pathogenic bacteria. Bacteria have evolved numerous strategies to colonize host mucosae, and among these are modulation of expression of cell surface adhesins which allow bacteria to bind to mucins. However, despite well structurally characterized adhesins and lectins, information on the nature and structure of oligosaccharides recognized by bacteria is still disparate. This review summarizes the current knowledge on the structure of epithelial mucin O-glycans and the interaction between host and commensal or pathogenic bacteria mediated by mucins.Lire moins >
Lire la suite >The gastrointestinal mucosal surface is the primary interface between internal host tissues and the vast microbiota. Mucins, key components of mucus, are high-molecular-weight glycoproteins characterized by the presence of many O-linked oligosaccharides to the core polypeptide. They play many biological functions, helping to maintain cellular homeostasis and to establish symbiotic relationships with complex microbiota. Mucin O-glycans exhibit a huge variety of peripheral sequences implicated in the binding of bacteria to the mucosal tissues, thereby playing a key role in the selection of specific species and in the tissue tropism displayed by commensal and pathogenic bacteria. Bacteria have evolved numerous strategies to colonize host mucosae, and among these are modulation of expression of cell surface adhesins which allow bacteria to bind to mucins. However, despite well structurally characterized adhesins and lectins, information on the nature and structure of oligosaccharides recognized by bacteria is still disparate. This review summarizes the current knowledge on the structure of epithelial mucin O-glycans and the interaction between host and commensal or pathogenic bacteria mediated by mucins.Lire moins >
Langue :
Anglais
Audience :
Non spécifiée
Établissement(s) :
CNRS
Université de Lille
Université de Lille
Équipe(s) de recherche :
Mécanismes moléculaires de la N-glycosylation et pathologies associées
Génétique des enveloppes bactériennes
Génétique des enveloppes bactériennes
Date de dépôt :
2020-02-12T15:44:39Z
2021-02-25T09:38:53Z
2021-02-25T09:40:26Z
2021-02-25T09:56:05Z
2021-02-25T09:57:34Z
2021-06-09T12:39:05Z
2021-02-25T09:38:53Z
2021-02-25T09:40:26Z
2021-02-25T09:56:05Z
2021-02-25T09:57:34Z
2021-06-09T12:39:05Z