Sialic Acid and Cancer
Type de document :
Partie d'ouvrage: Chapitre
URL permanente :
Titre :
Sialic Acid and Cancer
Auteur(s) :
Julien, Sylvain [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Delannoy, Philippe [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Delannoy, Philippe [Auteur]

Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Éditeur(s) ou directeur(s) scientifique(s) :
Taniguchi, Naoyuki
Endo, Tamao
Hart, Gerald W.
Seeberger, Peter H.
Wong, Chi-Huey
Endo, Tamao
Hart, Gerald W.
Seeberger, Peter H.
Wong, Chi-Huey
Titre de l’ouvrage :
Glycoscience : biology and medecine
Pagination :
1419-1424
Éditeur :
Springer Japan
Lieu de publication :
Tokyo
Date de publication :
2015
ISBN :
978-4-431-54840-9, 978-4-431-54841-6
Mot(s)-clé(s) en anglais :
Sialic acid
Tumor associated carbohydrate antigen
O-glycan
Ganglioside
Anticancer vaccine
Tumor associated carbohydrate antigen
O-glycan
Ganglioside
Anticancer vaccine
Discipline(s) HAL :
Chimie/Chimie théorique et/ou physique
Résumé en anglais : [en]
Sialic acids are nine-carbon acidic monosaccharides found in terminal position of glycan chains. The sialylation of cell surface glycoconjugates is frequently altered in cancers, resulting in the expression of sialylated ...
Lire la suite >Sialic acids are nine-carbon acidic monosaccharides found in terminal position of glycan chains. The sialylation of cell surface glycoconjugates is frequently altered in cancers, resulting in the expression of sialylated tumor-associated carbohydrate antigens that are specific markers for this disease. Because sialylated glycans are involved in many biological processes, their expression by tumor cells is often associated with increased aggressiveness and metastatic potential of the tumors. The sialylated tumor-associated carbohydrate antigens are usually weakly expressed by healthy tissues and can be therefore used as immunotherapeutic targets for anticancer vaccines. This chapter summarizes the main tumor-associated sialylated structures and their role in cancer cells biology as well as their use for the development of anticancer vaccines.Lire moins >
Lire la suite >Sialic acids are nine-carbon acidic monosaccharides found in terminal position of glycan chains. The sialylation of cell surface glycoconjugates is frequently altered in cancers, resulting in the expression of sialylated tumor-associated carbohydrate antigens that are specific markers for this disease. Because sialylated glycans are involved in many biological processes, their expression by tumor cells is often associated with increased aggressiveness and metastatic potential of the tumors. The sialylated tumor-associated carbohydrate antigens are usually weakly expressed by healthy tissues and can be therefore used as immunotherapeutic targets for anticancer vaccines. This chapter summarizes the main tumor-associated sialylated structures and their role in cancer cells biology as well as their use for the development of anticancer vaccines.Lire moins >
Langue :
Anglais
Audience :
Non spécifiée
Établissement(s) :
CNRS
Université de Lille
Université de Lille
Équipe(s) de recherche :
Régulation de la glycosylation terminale
Date de dépôt :
2020-02-12T15:44:44Z
2021-04-23T06:31:13Z
2021-04-23T06:31:13Z