Asking more from metabolic oligosaccharide engineering

Gilormini, Pierre-André; Batt, Anna R.; Pratt, Matthew R.; Biot, Christophe

Type de document :

Article dans une revue scientifique

DOI :

10.1039/C8SC02241K

URL permanente :

http://hdl.handle.net/20.500.12210/18704

Titre :

Asking more from metabolic oligosaccharide engineering

Auteur(s) :

Gilormini, Pierre-André [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Batt, Anna R. [Auteur]
University of Southern California [USC]
Pratt, Matthew R. [Auteur]
University of Southern California [USC]
Biot, Christophe [Auteur]

Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]

Titre de la revue :

Chemical Science

Numéro :

Pagination :

7585-7595

Date de publication :

2018

ISSN :

2041-6520, 2041-6539

Discipline(s) HAL :

Chimie/Chimie théorique et/ou physique

Résumé en anglais : [en]

Glycans form one of the four classes of biomolecules, are found in every living system and present a huge structural and functional diversity. As an illustration of this diversity, it has been reported that more than 50% ...
Lire la suite >Glycans form one of the four classes of biomolecules, are found in every living system and present a huge structural and functional diversity. As an illustration of this diversity, it has been reported that more than 50% of the human proteome is glycosylated and that 2% of the human genome is dedicated to glycosylation processes. Glycans are involved in many biological processes such as signalization, cell–cell or host pathogen interactions, immunity, etc. However, fundamental processes associated with glycans are not yet fully understood and the development of glycobiology is relatively recent compared to the study of genes or proteins. Approximately 25 years ago, the studies of Bertozzi's and Reutter's groups paved the way for metabolic oligosaccharide engineering (MOE), a strategy which consists in the use of modified sugar analogs which are taken up into the cells, metabolized, incorporated into glycoconjugates, and finally detected in a specific manner. This groundbreaking strategy has been widely used during the last few decades and the concomitant development of new bioorthogonal ligation reactions has allowed many advances in the field. Typically, MOE has been used to either visualize glycans or identify different classes of glycoproteins. The present review aims to highlight recent studies that lie somewhat outside of these more traditional approaches and that are pushing the boundaries of MOE applications.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

CNRS
Université de Lille

Collections :

Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576

Équipe(s) de recherche :

Chemical Glycobiology

Date de dépôt :

2020-02-12T15:45:31Z
2024-02-23T10:25:36Z
2024-02-23T10:26:43Z
2024-02-23T10:28:46Z

Historique des modifications

Numéro de version	Lien	Date de modification
4	20.500.12210/18704*	2024-02-23T10:28:18Z
3	20.500.12210/18704.3	2024-02-23T10:26:15Z
2	20.500.12210/18704.2	2024-02-23T10:23:33Z
1	20.500.12210/18704.1	2020-02-12T15:45:31Z

*Version sélectionnée

Asking more from metabolic oligosaccharide ... BibTeX CSV Excel RIS

Historique des modifications

Asking more from metabolic oligosaccharide ...

BibTeX

CSV

Excel

RIS