Asking more from metabolic oligosaccharide engineering

Gilormini, Pierre-André; Batt, Anna R.; Pratt, Matthew R.; Biot, Christophe

Document type :

Article dans une revue scientifique

DOI :

10.1039/C8SC02241K

Permalink :

http://hdl.handle.net/20.500.12210/18704

Title :

Asking more from metabolic oligosaccharide engineering

Author(s) :

Gilormini, Pierre-André [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Batt, Anna R. [Auteur]
University of Southern California [USC]
Pratt, Matthew R. [Auteur]
University of Southern California [USC]
Biot, Christophe [Auteur]

Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]

Journal title :

Chemical Science

Volume number :

Pages :

7585-7595

Publication date :

2018

ISSN :

2041-6520, 2041-6539

HAL domain(s) :

Chimie/Chimie théorique et/ou physique

English abstract : [en]

Glycans form one of the four classes of biomolecules, are found in every living system and present a huge structural and functional diversity. As an illustration of this diversity, it has been reported that more than 50% ...
Show more >Glycans form one of the four classes of biomolecules, are found in every living system and present a huge structural and functional diversity. As an illustration of this diversity, it has been reported that more than 50% of the human proteome is glycosylated and that 2% of the human genome is dedicated to glycosylation processes. Glycans are involved in many biological processes such as signalization, cell–cell or host pathogen interactions, immunity, etc. However, fundamental processes associated with glycans are not yet fully understood and the development of glycobiology is relatively recent compared to the study of genes or proteins. Approximately 25 years ago, the studies of Bertozzi's and Reutter's groups paved the way for metabolic oligosaccharide engineering (MOE), a strategy which consists in the use of modified sugar analogs which are taken up into the cells, metabolized, incorporated into glycoconjugates, and finally detected in a specific manner. This groundbreaking strategy has been widely used during the last few decades and the concomitant development of new bioorthogonal ligation reactions has allowed many advances in the field. Typically, MOE has been used to either visualize glycans or identify different classes of glycoproteins. The present review aims to highlight recent studies that lie somewhat outside of these more traditional approaches and that are pushing the boundaries of MOE applications.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CNRS
Université de Lille

Collections :

Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576

Research team(s) :

Chemical Glycobiology

Submission date :

2020-02-12T15:45:31Z
2024-02-23T10:25:36Z
2024-02-23T10:26:43Z
2024-02-23T10:28:46Z

Version history

Version	Link	Modification date
4	20.500.12210/18704*	2024-02-23T10:28:18Z
3	20.500.12210/18704.3	2024-02-23T10:26:15Z
2	20.500.12210/18704.2	2024-02-23T10:23:33Z
1	20.500.12210/18704.1	2020-02-12T15:45:31Z

*Selected version

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