Structure and dynamics of a human myelin ...
Document type :
Article dans une revue scientifique
Permalink :
Title :
Structure and dynamics of a human myelin protein P2 portal region mutant indicate opening of the β barrel in fatty acid binding proteins
Author(s) :
Laulumaa, Saara [Auteur]
University of Oulu
Nieminen, Tuomo [Auteur]
Tampere University of Technology [Tampere] [TUT]
Raasakka, Arne [Auteur]
University of Bergen [UiB]
Krokengen, Oda C. [Auteur]
University of Bergen [UiB]
Safaryan, Anushik [Auteur]
University of Bergen [UiB]
Hallin, Erik I. [Auteur]
University of Bergen [UiB]
Brysbaert, Guillaume [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Lensink, Marc [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Ruskamo, Salla [Auteur]
University of Oulu
Vattulainen, Ilpo [Auteur]
Tampere University of Technology [Tampere] [TUT]
Kursula, Petri [Auteur]
University of Oulu
University of Oulu
Nieminen, Tuomo [Auteur]
Tampere University of Technology [Tampere] [TUT]
Raasakka, Arne [Auteur]
University of Bergen [UiB]
Krokengen, Oda C. [Auteur]
University of Bergen [UiB]
Safaryan, Anushik [Auteur]
University of Bergen [UiB]
Hallin, Erik I. [Auteur]
University of Bergen [UiB]
Brysbaert, Guillaume [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Lensink, Marc [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Ruskamo, Salla [Auteur]
University of Oulu
Vattulainen, Ilpo [Auteur]
Tampere University of Technology [Tampere] [TUT]
Kursula, Petri [Auteur]
University of Oulu
Journal title :
BMC Structural Biology
Volume number :
18
Publication date :
2018-12
ISSN :
1472-6807
HAL domain(s) :
Chimie/Chimie théorique et/ou physique
English abstract : [en]
Myelin is a multilayered proteolipid sheath wrapped around selected axons in the nervous system. Its constituent proteins play major roles in forming of the highly regular membrane structure. P2 is a myelin-specific protein ...
Show more >Myelin is a multilayered proteolipid sheath wrapped around selected axons in the nervous system. Its constituent proteins play major roles in forming of the highly regular membrane structure. P2 is a myelin-specific protein of the fatty acid binding protein (FABP) superfamily, which is able to stack lipid bilayers together, and it is a target for mutations in the human inherited neuropathy Charcot-Marie-Tooth disease. A conserved residue that has been proposed to participate in membrane and fatty acid binding and conformational changes in FABPs is Phe57. This residue is thought to be a gatekeeper for the opening of the portal region upon ligand entry and egress.Show less >
Show more >Myelin is a multilayered proteolipid sheath wrapped around selected axons in the nervous system. Its constituent proteins play major roles in forming of the highly regular membrane structure. P2 is a myelin-specific protein of the fatty acid binding protein (FABP) superfamily, which is able to stack lipid bilayers together, and it is a target for mutations in the human inherited neuropathy Charcot-Marie-Tooth disease. A conserved residue that has been proposed to participate in membrane and fatty acid binding and conformational changes in FABPs is Phe57. This residue is thought to be a gatekeeper for the opening of the portal region upon ligand entry and egress.Show less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
CNRS
Université de Lille
Université de Lille
Research team(s) :
Computational Molecular Systems Biology
Submission date :
2020-02-12T15:45:41Z
2024-02-23T10:40:58Z
2024-02-23T10:40:58Z