Titre :

Reduced Graphene-Oxide-Embedded Polymeric Nanofiber Mats: An “On-Demand” Photothermally Triggered Antibiotic Release Platform

Auteur(s) :

Altinbasak, Ismail [Auteur]
Jijie, Roxana [Auteur]
Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 [IEMN]
Barras, Alexandre [Auteur]
Institut d'Électronique, de Microélectronique et de Nanotechnologie (IEMN) - UMR 8520
Golba, Bianka [Auteur]
Sanyal, Rana [Auteur]
Bouckaert, Julie [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Drider, Djamel [Auteur]
BioEcoAgro - UMR-T 1158
Institut Charles Viollette (ICV) - EA 7394 [ICV]
Bilyy, Rostyslav [Auteur]
Dumych, Tetiana [Auteur]
Paryzhak, Solomiya [Auteur]
Vovk, Volodymyr [Auteur]
Boukherroub, Rabah [Auteur]
Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 [IEMN]
Sanyal, Amitav [Auteur]
Szunerits, Sabine [Auteur]
Institut d'Électronique, de Microélectronique et de Nanotechnologie (IEMN) - UMR 8520
Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 [IEMN]
Jijie, Roxana [Auteur]

Titre de la revue :

ACS Applied Materials & Interfaces

Numéro :

10

Pagination :

41098-41106

Date de publication :

2018-12-05

ISSN :

1944-8244, 1944-8252

Mot(s)-clé(s) en anglais :

electrospinning
nanofibers
reduced graphene oxide
antibiotic release
photothermal effect

Discipline(s) HAL :

Chimie/Chimie théorique et/ou physique

Résumé en anglais : [en]

The steady increase of antimicrobial resistance of different pathogens requires the development of alternative treatment strategies next to the oral delivery of antibiotics. A photothermally activated platform based on ...
Lire la suite >The steady increase of antimicrobial resistance of different pathogens requires the development of alternative treatment strategies next to the oral delivery of antibiotics. A photothermally activated platform based on reduced graphene oxide (rGO)-embedded polymeric nanofiber mats for on-demand release of antibiotics upon irradiation in the near-infrared is fabricated. Cross-linked hydrophilic nanofibers, obtained by electrospinning a mixture of poly(acrylic acid) (PAA) and rGO, show excellent stability in aqueous media. Importantly, these PAA@ rGO nanofiber mats exhibit controlled photothermal heating upon irradiation at 980 nm. Nanofiber mats are efficiently loaded with antibiotics through simple immersion into corresponding antibiotics solutions. Whereas passive diffusion based release at room temperature is extremely low, photothermal activation results in increased release within few minutes, with release rates tunable through power density of the applied irradiation. The large difference over passive and active release, as well as the controlled turn-on of release allow regulation of the dosage of the antibiotics, as evidenced by the inhibition of planktonic bacteria growth. Treatment of superficial skin infections with the antibiotic-loaded nanofiber mats shows efficient wound healing of the infected site. Facile fabrication and implementation of these photothermally active nanofiber mats makes this novel platform adaptable for on-demand delivery of various therapeutic agents.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Institut Catholique Lille
Université de Lille
ISEN
Univ. Valenciennes
CNRS
INRA
ISA
Centrale Lille
Univ. Artois
Univ. Littoral Côte d’Opale

Collections :

• BioEcoAgro - UMR-T 1158
• Institut d'Électronique, de Microélectronique et de Nanotechnologie (IEMN) - UMR 8520
• Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576

Équipe(s) de recherche :

Computational Molecular Systems Biology

Date de dépôt :

2020-02-12T15:45:43Z
2024-03-15T10:35:07Z