Title :

The molecular signal for the adaptation to cold temperature during early life on Earth

Author(s) :

Groussin, Mathieu [Auteur correspondant]
Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 [LBBE]
Boussau, Bastien [Auteur]
Bioinformatique, phylogénie et génomique évolutive [BPGE]
Charles, Sandrine [Auteur]
Modélisation et écotoxicologie prédictives
Blanquart, Samuel [Auteur]
Bioinformatics and Sequence Analysis [BONSAI]
Gouy, Manolo [Auteur]
Bioinformatique, phylogénie et génomique évolutive [BPGE]

Journal title :

Biology Letters

Pages :

20130608

Publisher :

Royal Society, The

Publication date :

2013-10-23

ISSN :

1744-9561

HAL domain(s) :

Sciences du Vivant [q-bio]/Bio-Informatique, Biologie Systémique [q-bio.QM]
Informatique [cs]/Bio-informatique [q-bio.QM]

English abstract : [en]

Several lines of evidence such as the basal location of thermophilic lineages in large-scale phylogenetic trees and the ancestral sequence reconstruction of single enzymes or large protein concatenations support the ...
Show more >Several lines of evidence such as the basal location of thermophilic lineages in large-scale phylogenetic trees and the ancestral sequence reconstruction of single enzymes or large protein concatenations support the conclusion that the ancestors of the bacterial and archaeal domains were thermophilic organisms which were adapted to hot environments during the early stages of the Earth. A parsimonious reasoning would therefore suggest that the last universal common ancestor (LUCA) was also thermophilic. Various authors have used branch-wise non-homogeneous evolutionary models that better capture the variation of molecular compositions among lineages to accurately reconstruct the ancestral G + C contents of ribosomal RNAs and the ancestral amino acid composition of highly conserved proteins. They confirmed the thermophilic nature of the ancestors of Bacteria and Archaea but concluded that LUCA, their last common ancestor, was a mesophilic organism having a moderate optimal growth temperature. In this letter, we investigate the unknown nature of the phylogenetic signal that informs ancestral sequence reconstruction to support this non-parsimonious scenario. We find that rate variation across sites of molecular sequences provides information at different time scales by recording the oldest adaptation to temperature in slow-evolving regions and subsequent adaptations in fast-evolving ones.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Collections :

• Centre de Recherche en Informatique, Signal et Automatique de Lille (CRIStAL) - UMR 9189

Source :

Harvested from HAL