Protein Sequencing with an Adaptive Genetic ...
Type de document :
Communication dans un congrès avec actes
Titre :
Protein Sequencing with an Adaptive Genetic Algorithm from Tandem Mass Spectrometry
Auteur(s) :
Boisson, Jean-Charles [Auteur correspondant]
Parallel Cooperative Multi-criteria Optimization [DOLPHIN]
Laboratoire d'Informatique Fondamentale de Lille [LIFL]
Jourdan, Laetitia [Auteur]
Parallel Cooperative Multi-criteria Optimization [DOLPHIN]
Laboratoire d'Informatique Fondamentale de Lille [LIFL]
Talbi, El-Ghazali [Auteur]
Parallel Cooperative Multi-criteria Optimization [DOLPHIN]
Rolando, Christian [Auteur]
Laboratoire de Chimie Organique et Macromoleculaire [UMR CNRS 8009]
Parallel Cooperative Multi-criteria Optimization [DOLPHIN]
Laboratoire d'Informatique Fondamentale de Lille [LIFL]
Jourdan, Laetitia [Auteur]

Parallel Cooperative Multi-criteria Optimization [DOLPHIN]
Laboratoire d'Informatique Fondamentale de Lille [LIFL]
Talbi, El-Ghazali [Auteur]

Parallel Cooperative Multi-criteria Optimization [DOLPHIN]
Rolando, Christian [Auteur]

Laboratoire de Chimie Organique et Macromoleculaire [UMR CNRS 8009]
Titre de la manifestation scientifique :
CEC 2006
Ville :
Vancouver
Pays :
Canada
Date de début de la manifestation scientifique :
2006-07-16
Date de publication :
2006
Mot(s)-clé(s) en anglais :
Proteomics
protein sequencing
tandem mass spectrometry
protein sequencing
tandem mass spectrometry
Discipline(s) HAL :
Informatique [cs]/Bio-informatique [q-bio.QM]
Sciences du Vivant [q-bio]/Bio-Informatique, Biologie Systémique [q-bio.QM]
Sciences du Vivant [q-bio]/Bio-Informatique, Biologie Systémique [q-bio.QM]
Résumé en anglais : [en]
In Proteomics, only the de novo peptide sequencing approach allows a partial amino acid sequence of a peptide to be found from a MS/MS spectrum. In this article a preliminary work is presented to discover a complete protein ...
Lire la suite >In Proteomics, only the de novo peptide sequencing approach allows a partial amino acid sequence of a peptide to be found from a MS/MS spectrum. In this article a preliminary work is presented to discover a complete protein sequence from spectral data (MS and MS/MS spectra). For the moment, our approach only uses MS spectra. A Genetic Algorithm (GA) has been designed with a new evaluation function which works directly with a complete MS spectrum as input and not with a mass list like the other methods using this kind of data. Thus the mono isotopic peak extraction step which needs a human intervention is deleted. The goal of this approach is to discover the sequence of unknown proteins and to allow a better understanding of the differences between experimental proteins and proteins from databases.Lire moins >
Lire la suite >In Proteomics, only the de novo peptide sequencing approach allows a partial amino acid sequence of a peptide to be found from a MS/MS spectrum. In this article a preliminary work is presented to discover a complete protein sequence from spectral data (MS and MS/MS spectra). For the moment, our approach only uses MS spectra. A Genetic Algorithm (GA) has been designed with a new evaluation function which works directly with a complete MS spectrum as input and not with a mass list like the other methods using this kind of data. Thus the mono isotopic peak extraction step which needs a human intervention is deleted. The goal of this approach is to discover the sequence of unknown proteins and to allow a better understanding of the differences between experimental proteins and proteins from databases.Lire moins >
Langue :
Anglais
Comité de lecture :
Oui
Audience :
Internationale
Vulgarisation :
Non
Collections :
Source :
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- 0804.1201
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